13th Annual Conference of the British HIV Association 29 March–1 April 2007, Brighton, UK

MONITORING CLINICAL OUTCOMES. #1: VIROLOGICAL FAILURE AND DISCONTINUATION 1 YEAR AFTER STARTING ANTIRETROVIRAL THERAPY

HIV Med 2007; 8(Suppl. 1):4 (abstract no. O13)

Tim Chadborn, Victoria Bryant and Valerie Delpech
¹Health Protection Agency, London, UK, ²Audit and Outcomes Subgroup of the HIV Consortium, London, UK

AIM/OBJECTIVE: To develop pilot clinical outcomes, in accordance with the London HIV Strategy, which can be monitored locally and used to guide improvement in the health of people living with HIV. The first pilot outcome aims to determine the proportion of people with detectable viral load (VL) and/or drug discontinuation 1 year after first starting antiretroviral therapy (ART).

METHODS: Reports to SOPHID (repeated, national cross-sectional survey of HIV-infected individuals seen for HIV care) that related to an individual were linked over time. Individuals were included who had a VL measured 9–15 months after their ART start date. Women no longer on ART were excluded as likely to be pregnant women on therapy to prevent mother-to-child transmission.

RESULTS: In London, 1123 individuals started ART between July 2004 and June 2005 and had VL and ART data reported after 9–15 months. Overall, 92 (8%) individuals had a VL >500 copies/mL and 31 (3%) had discontinued or interrupted therapy. For London sites with more than 20 individuals starting ART, proportions with VL >500 ranged from 0 to 19% and drug discontinuation ranged from 0 to 7%. Overall ‘failure’ rates ranged from 3 to 21%.

CONCLUSION/DISCUSSION: This analysis indicates that London sites achieved very good responses to ART. Further investigation and collaboration should determine whether differences were because of case mix or patient management. This demonstrates the feasibility of national monitoring of clinical outcomes.

2007-03-29
O13

Copyright © 2007 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD