13th Annual Conference of the British HIV Association 29 March–1 April 2007, Brighton, UK

A PROSPECTIVE STUDY OF CARDIOVASCULAR RISK IN HIV COHORT

HIV Med 2007; 8(Suppl. 1):8 (abstract no. O30)

Michael Aboud¹, Ali Elgalib¹, Laura Pomeroy¹, Elias Skopelitis², Bijal Kothari³, Ranjababu Kulasegaram¹, Alistair Duncan¹, Anthony Wierzbicki¹, Nick Larbalestier¹, Fiona Lampe⁴, George Panayiotakopoulos², Alice Sharp⁴, Caroline Dimian⁵ and Barry Peters^1
1HIV Unit, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, UK, ²Academic Unit of HIV and STDs, St Thomas’ site of King’s College, London, UK, ³Guy’s Kings and St Thomas’ School of Medicine, King’s College, London, Guy’s Hospital Campus, London, UK, ⁴Department of Population Sciences, Royal Free site of UCL, London, UK, ⁵Department of GUM, Beckenham Hospital, Beckenham, Kent, UK

OBJECTIVE: HIV and HAART have been associated with an increase in predicted cardiovascular risk (CVR) and observed cardiac events. We prospectively conducted a cross-sectional multi-centre study to determine whether ethnicity, use of HAART and other factors had an independent effect on 10-year CVR.

METHODS: A total of 1012 randomly selected patients from two HIV referral centres underwent 10-year cardiovascular risk assessment according to the National Cholesterol Education Program Panel III guidelines. Source data were rigorously checked, entered onto Excel, and analysed by EpiInfo. The results from the Health Survey for England 2004 were used as a control group.

RESULTS: The mean 10-year CVR for males (n=752, 74%) versus females (n=260, 26%) was 5.4 versus 1.46 (P<0.0001), Caucasian (n=504, 49.8%) versus African (n=331, 32.7% ) was 5.41 versus 2.36 (P<0.001), on HAART (n=750, 74%) versus HAART naïve (n=262, 26%) 4.55 versus 3.28 (P<0.0004), PI-HAART (n=243, 24%) versus non-PI HAART (n=399, 39.4%) 4.50 versus 4.72 (P<0.74), smoking (n=377, 37.3%) versus nonsmoking (n=635, 62.7%) 6.78 versus 2.75 (P<0.0001). A correlation with 10-year CVR was also found for increased age (P<0.001) and CDC stage (P<0.0036).

CONCLUSION: Male gender, Caucasian ethnicity, smoking, increased age, and use of HAART were all positively correlated with an increased 10-year CVR. Interestingly, there was no significant difference between being on PI-versus non-PI regimens, at the time of assessment, for 10-year CVR. With raised CVR, priority should be given to correcting modifiable risk factors such as smoking, lipids and systolic BP.

2007-03-29
O30

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