13th Annual Conference of the British HIV Association 29 March–1 April 2007, Brighton, UK

PROSPECTIVE STUDY OF STATIN USAGE AMONG A LARGE HIV COHORT: ASSOCIATION WITH SUPERIOR VIROLOGICAL AND IMMUNOLOGICAL RESPONSE

HIV Med 2007; 8(Suppl. 1):12 (abstract no. P10)

Elias Skopelitis³, Ali Elgalib¹, Michael Aboud¹, Laura Pomeroy³, Ranjababu Kulasegaram¹, Alistair Duncan¹, Anthony Wierzbicki¹, Nick Larbalestier¹, Fiona Lampe², Alice Sharp³, Caroline Dimian⁴ and Barry Peters^1
1HIV Unit, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, UK, ²Department of Population Sciences, Royal Free site of UCL, London, UK, ³Academic Unit of HIV and STDs, St Thomas’ site of King’s College, London, UK, ⁴Department of GUM, Beckenham Hospital, Beckenham, Kent, UK

AIM: To investigate the characteristics of statin use in a prospective cross- sectional HIV cohort study in two inner-city referral centres.

PATIENTS AND METHODS: Demographics, HIV surrogate/treatment data, anthropometrics and serum lipid profile were obtained for 1022 patients: 75% males, median age 40 (range 19–77), Caucasians 51%, Africans 34%, symptomatic/ AIDS 49.8%, on HAART 74.4%, on protease inhibitors (PIs) 39.7%, median ± SD CD4 442.4 ± 222.39 cells/µl, HIV-1 RNA <50 copies/mL in 61%. Comparisons between groups were done using Chi-squared and Mann–Whitney U tests.

RESULTS: 11.1% of our population is on statin therapy (ST) (16.8% of females and 9.1% of males) compared with 2.3% (2.6% of females and 1.9% of males) in the age-matched UK population. 93.6% of patients on ST were receiving HAART and 47.2% PIs, compared to 71.9% (P<0.001) and 39.6% (P=0.8) respectively, for those not on ST. Patients on ST compared to those not on ST, were older (median age 45 versus 39, P<0.001), with higher BMI (mean 27.6 versus 25.2, P<0.001), higher CD4 count (mean 526.2 versus 433.9, P<0.001) and higher proportion of undetectable viral load (88.2% versus 57.9%, P<0.001). These significant differences remained when the analysis included only patients receiving HAART. Statin use did not differ significantly according to ethnicity and HIV stage.

CONCLUSIONS: 1. The increased use of statins in our HIV cohort compared to an age-matched UK population, partly reflects the effects of HIV therapy, but also an increased awareness and prompt intervention. 2. Statin use is linked to a better virological and immunological response, and independent of concomitant use of HAART.

2007-03-29
P10

Copyright © 2007 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD