13th Annual Conference of the British HIV Association 29 March–1 April 2007, Brighton, UK

AN AUDIT OF THE VIRAL LOAD OF PATIENTS FROM ONE CLINIC COHORT ON JANUARY 1ST 2005 TO SEE WHO IS VIROLOGICALLY FAILING ART

HIV Med 2007; 8(Suppl. 1):11 (abstract no. P7)

Sara Madge, Colette Smith, Caroline Sabin, Mike Youle, Margaret Johnson and Andrew Phillips
Royal Free Centre for HIV Medicine, London, UK

AIM: Firstly to describe the distribution of viral load (V/L) results in a clinic cohort, specifically focusing on those who achieve a viral load of <50 on at least 16 weeks ART and secondly to describe the characteristics of those with a viral load above 400 copies despite ART.

METHODS: All patients in an established clinic cohort followed up on January 1st 2005 were included. We identified those with a V/L >400 despite ART from the clinic database, and collected information from the clinical notes for 6 months either side of the viral load result.

RESULTS: 1913 patients were included, of whom 1334 (70%) had been on ART for >16 weeks. 1307 of the whole cohort (68%) had V/L <50 of whom 1228 were on ART for >16 weeks. Therefore the prevalence of V/L <50 on established ART was 92% (1228/1334). Of those on ART for >16 weeks, 106 (8%) had a V/L >50 and 59 (4%) had a V/L >400. Factors in these 59 patients with a V/L >400 when compared to those successfully on ART, showed that prior mono or dual nucleoside use (P=0.006), and prior AIDS diagnosis (P=0.06), were associated with a greater risk of V/L >400. Gender, ethnicity, age, risk group, CD4 at ART were not. The notes of these 59 were reviewed (48 found). 22 (46%) had prior mono or dual nucleoside exposure, 27 (56%) had documented poor compliance, 16 (33%) had limited drug options, 20 (42%) were unwell mainly resulting from AIDS-related illness and 11 (23%) had multiple drug therapy.

CONCLUSIONS: The vast majority of patients on ART in this cohort on January 1st 2005 had a viral load <50. Documented poor compliance was common amongst viraemic patients as was poor physical health. In the whole cohort on ART only 16 patients appeared to have limited drug options.

2007-03-29
P7

Copyright © 2007 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD