14th Annual Conference of the British HIV Association 23–25 April 2008, Belfast

TREATMENT OF METATARSAL FAT PAD LIPOATROPHY WITH VOLUMIZING INJECTIONS

HIV Med 2008; 9(Suppl. 1):35 (abstract no. P94)

A Kavouni¹, E O’Donovan¹, S Brown¹, S Barton¹, M Nelson¹, S Levine² and E Lautin^2
1Chelsea and Westminster Hospital, London, UK, ²Institute Beaute´, New York, USA

BACKGROUND: The impact of loss of metatarsal fat pads adds significantly to the pathology of lipoatrophic foot changes causing pain and restricting mobility. Poly-L-Lactic acid injections (PLLA) produce tissue augmentation through collagen stimulation and are an established treatment for facial lipoatrophy.

METHODS: HIV-positive individuals with foot lipoatrophy were given three bilateral PLLA injections 2 weeks apart into the dermis-subcutis level overlying the 1st metatarsal head. Assessments included feet ultrasound and visual analogue scales.

RESULTS:7 consecutive patients completed the treatment. Injections were well tolerated and no adverse events were recorded. Patient visual analogue assessments of pain, distress and impact on activity significantly improved at week 8 post treatment (P=0.002). Skin and subcutaneous tissue thickness of the 1st metatarsal fat pad increased significantly at week 8 post treatment (P=0.005 and P=0.04 respectively).

CONCLUSIONS: PLLA injections led to improvements in pain distress and activity scores in individuals with lipoatrophy of the foot. There were no adverse effects and the tissue augmentation was significant at 8 weeks after the last injection.

2008-04-23
P94

Copyright © 2008 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD