15th Annual Conference of the British HIV Association 1-3 April 2009, Liverpool, UK

AIDS KAPOSI’S SARCOMA: OUTCOMES IN 254 CONSECUTIVE PATIENTS DIAGNOSED IN MODERN TIMES

HIV Med 2009 Apr 1-3 (Suppl 1);15:14 (abstract no. O30)

S Powles, J Weir, N Francis, T Newsom-Davis, T Crook, M Boffito, M Nelson and M Bower
Chelsea & Westminster Hospital, London, UK

BACKGROUND: A prospective cohort study was performed to evaluate the clinical outcomes of patients with histologically confirmed AIDS related Kaposi’s sarcoma (KS) diagnosed since the introduction of highly active antiretroviral therapy (HAART).

METHODS: Two hundred and fifty-four consecutive patients (96% male) diagnosed with KS between 1996 and 2008 are included. Clinicopathological and treatment details were prospectively collected. The median follow up is over 4 years and maximum 12 years.

RESULTS: The mean age at KS diagnosis is 39 years and average duration of known HIV seropositivity is 4 years. At KS diagnosis only 19% were on HAART and only 7% had an undetectable plasma HIV viral load. Seventy nine (31%) patients had AIDS clinical Trial Group (ACTG) stage T1 disease at KS diagnosis and 122 (48%) had ACTG stage I1 disease (CD4 <150 mm^-3). Nodular grade KS represented 28% of the tumours and was significantly associated with black African ethnicity and ACTG T1 stage disease. The overall 5 year survival is 89% (95% confidence interval: 84–93%). 163 antiretroviral-naïve patients were treated with HAART alone for T0 stage KS; only one died of KS and only 37 (22%) required chemotherapy, giving a systemic treatment free survival at 5 years of 74% (95% CI: 67–82%) and the overall survival at 5 years is 91% (95%CI: 87–95%).

CONCLUSIONS: The high success rate of HAART in a large cohort of antiretroviral-naïve patients over a prolonged period of follow-up will reassure patients and clinicians that this is a safe and effective approach to stage T0 KS.

2009-04-01
O30

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