2nd National Conference Human Retroviruses and Related Infections Washington, DC - January 29 - February 2, 1995

Natl Conf Hum Retrovir Relat Infect 1995 Jan 29-Feb 2;2: (abstract no. 14)

Cleghorn F, Jack N, Greenberg M, Weinhold K, Edwards J, Murphy J, Paul R, Mahabir B, O'Brien T, Bartholomew C
National Cancer Institute, RTI and Duke, USA; CAREC, UWI, and MOH, Trinidad

OBJECTIVES: Evaluate clinical and laboratory correlates of primary clade B HIV-1 infection.

METHODS: 9000+ consecutive STD attenders in Trinidad screened for HIV-1 P24 antigen and antibodies with informed consent.

RESULTS: 91 (1.0%) are P24 Ag positive (69% also antibody positive). Seroconversion in 8 cases within 8 to 35 days. Symptoms reported in 6 to 7 (with clinical data); only one sought medical attention. Antibody dependent cellular cytotoxicity (ADCC) appears concomitant with clearance of plasma viremia; neutralizing antibody detectable 2 - 3 months post seroconversion. High virus expression and persistent low CD4 count occur in a small number, and rapid CD4 cell recovery and suppression of virus expression are detected in the majority.

CONCLUSION: Severe symptoms of HIV-1 seroconversion are rare in this cohort. ADCC not neutralizing antibody correlate with down modulation of viral expression and CD4 recovery.

Keywords: Antibody-Dependent Cell Cytotoxicity, Antigens, CD4, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, HIV Infections, HIV Seropositivity, Trinidad and Tobago, Viremia, immunology, virology

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1995-01-29
14

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