2nd National Conference Human Retroviruses and Related Infections Washington, DC - January 29 - February 2, 1995

Natl Conf Hum Retrovir Relat Infect 1995 Jan 29-Feb 2;2: (abstract no. 16)

Conley LJ¹, Bush TJ¹, Buchbinder SP², Penley KA³, Judson FN³, Holmberg SD^1
1Centers for Disease Control and Prevention, Atlanta, GA; ²San Francisco Department of Health; ³Denver Disease Control Service and the University of Colorado Health Sciences Center

BACKGROUND: The effect of cigarette smoking on the development of conditions associated with HIV-infection is unclear and controversial.

METHODS: We analyzed data on 516 HIV-infected men from cohorts of homosexual and bisexual men in San Francisco, Denver, and Chicago who had been repeatedly interviewed and examined between 1988 and 1992. After excluding men who did not have well-defined dates of HIV seroconversion and men who were classified as ex- or intermittent smokers, 232 men remained for analysis: 106 were smokers and 126 were non-smokers. Univariate and Kaplan-Meier survival analyses were performed to assess the relationship between cigarette smoking and a diagnosis of any AIDS-defining illness, loss of CD4+ cells, Kaposi's sarcoma (KS), Pneumocystis carinii pneumonia (PCP), oral candidiasis (OC), hairy leukoplakia (HL), and bacterial pneumonia (BP).

RESULTS: By univariate analyses, cigarette smoking was not associated with AIDS, loss of CD4 cells, KS or PCP (p=0.976, 0.897, and 0.077), but was associated with OC (p=0.035), HL (p=0.003), and BP (p=0.005). Dose response effect was also evident for OC, HL, and BP (all p<0.01). Kaplan-Meier analysis also indicated no association between cigarette smoking and progression to AIDS, KS, or PCP (p=0.638,0.650, and 0.052) but showed that smokers developed OC, HL and BP more quickly than non-smokers (p=0.031,0.003, and 0.008).

CONCLUSIONS: Cigarette development of HIV-associated oral candidiasis, hairy leukoplakia, and bacterial pneumonia.

Keywords: Acquired Immunodeficiency Syndrome, Bisexuality, Candidiasis, Oral, Chicago, Disease Progression, HIV Infections, HIV Seropositivity, Homosexuality, Humans, Leukoplakia, Hairy, Male, Pneumonia, Pneumocystis, San Francisco, Sarcoma, Kaposi, Smoking, Survival Analysis

Download abstract

1995-01-29
16

Copyright © 1995 - The American Society for Microbiology. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the American Society for Microbiology.