AEGiS-07CROI: Spectrum of AIDS-associated malignancies in New York City.

7th Conference on Retroviruses and Opportunistic Infections

San Francisco, CA - January 30 -February 4, 2000

SPECTRUM OF AIDS-ASSOCIATED MALIGNANCIES IN NEW YORK CITY.

Conf Retroviruses Opportunistic Infect 2000 Jan 30-Feb 2; 7:77 (abstract no. 10)

J. Fordyce¹, Z. Wang², B. Gallagher², S. Ly¹, A. Hahn², M. Schymura², and M. Chiasson¹
¹New York City Dept. of Hlth., NY and ²New York State Dept. of Hlth., Albany.

OBJECTIVES: To determine if the risk of cancers not included in the AIDS case definition is elevated among persons with AIDS, and which cancers increase with declining immunodeficiency.

METHODS: New York City AIDS and New York State Cancer Registries were matched by name, date of birth, and Social Security Numbers for 106,768 persons with AIDS and 1,602,800 persons with cancer between 1980 and 1994. Relative risk (RR) of cancer was defined as the ratio of observed to expected cancers among persons with AIDS based upon population rates matched for age, sex and race. AIDS-associated cancers were defined as those with significantly raised RRs post AIDS and increasing prevalence from 5 years before to 5 years after an AIDS diagnosis. Analysis was limited to New York City residents who were age 15 to 69 at AIDS diagnosis.

RESULTS: Among people with AIDS there were 7,243 AIDS and 2,411 non-AIDS defining cancers. Post AIDS RRs were increased 61.89 fold for AIDS defining and 4.2 fold for non-AIDS defining cancers. Elevated post AIDS RRs for cancers by cell type or site which increased significantly over time (p<.02) were found for Hodgkin's disease (5.52), anal cancer (4.95), multiple myeloma (4.39), brain cancer (3.78), lung cancer (3.40) and cancers of the larynx (2.71) and stomach (2.33).

CONCLUSIONS: Incomplete determination of behavioral risk factors and differences in AIDS and cancer surveillance complicates determination of cancer risks. Significantly increased risks for several non-AIDS defining cancers suggests AIDS may be associated with cancers thought to be linked with other viruses. Additional analysis is required to test for the the effects of new anti-viral therapies on the the development of cancer.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Neoplasms, Risk Factors, Anus Neoplasms, Risk, Prevalence, New York City, Hodgkin Disease, New York, Case-Control Studies, AIDS

2000-01-30
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Copyright © 2000 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.