7th Conference on Retroviruses and Opportunistic Infections


San Francisco, CA - January 30 -February 4, 2000



GENDER DIFFERENCES IN HIV-ASSOCIATED ADIPOSE REDISTRIBUTION SYNDROME: AN UPDATE.

Conf Retroviruses Opportunistic Infect 2000 Jan 30-Feb 2; 7:80 (abstract no. 26)

N. Muurahainen1, G. Santos2, M. Kleintop1, R. Pettit1, J. Balser1, J. Falutz3, M. Glesby4, D. Kotler5, and the SALSA Investigators Group
1Serono Labs Inc., Norwell, MA; 2Betances Hlth. Unit, New York, NY; 3Montreal Gen. Hosp., Quebec, Canada; 4Cornell Univ., New York, and 5St. Luke’s-Roosevelt Hosp., New York, NY

OBJECTIVE: To compare manifestations of HARS or lipodystrophy syndrome' in a database of male (M) & female (F) HIV patient (pt) case reports.

METHODS: The survey included 395 pts from 49 centers accruing cases with body shape abnormalities diagnosed by MD physical exam and patient self-assessment. Cases were classified as having any fat accumulation (FA), any fat depletion (FD) or both. SALSA™ (self-ascertained lipodystrophy syndrome assessment) questionnaires asked in detail about morphology. Chart review established histories (hx) of hypertriglyceridemia (HTG), hypercholesterolemia (HC), and hyperglycemia (HGL). Gender differences were ascertained by Fisher's exact test.

RESULTS: The 324 M and 71 F cases were aged 25 to 71 (mean = 43) years, with mean (± SD) CD4 counts 404 (± 607cells/mm3), mean BMI 26 (± 11) kg/m2 , and 62% with plasma HIV-1-RNA below 500 copies/ml (VL<500). There were no significant gender differences in percentages (%) with VL<500, and % receiving antiretrovirals (97%M, 94%F), but 19%M and 37%F had not received protease inhibitors (p<.0014). Fat accumulation (FA, in the breast area, abdomen, neck, and/or as a hump) occurred in 84%M and 97%F (p <.0019). Fat depletion (FD, in the face, limbs, and/or buttocks) occurred in 77%M and 61%F (p<.0069). A mix (FA+FD) was reported in 65% M and 58%F (NS). Hx of HTG, HC, & HGL was noted in 68%, 54%, and 11% of male cases, and 32%, 32%, and 7% of female cases, respectively (p < .001, .001, NS).

CONCLUSION: When surveyed using the same methodology, M & F with HARS present with different patterns of morphologic and metabolic abnormalities. Additional investigation is needed to delineate the extent to which these gender differences may be attributable to drug, immunologic, hormonal, or other parameters.

Keywords: AEGIS, HIV, HIV-Associated Lipodystrophy Syndrome, Lipodystrophy, Syndrome, Sex Characteristics, HIV Infections, CD4 Lymphocyte Count, HIV-1, Anti-HIV Agents, Body Mass Index, Body Constitution, Protease Inhibitors, Obesity, Hyperglycemia, Human, Female, Male, AIDS

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2000-01-30
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Copyright © 2000 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.