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10th Conference on Retroviruses and Opportunistic InfectionsBoston, MA USA - February 10 -14, 2003 |
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Conf Retroviruses Opportunistic Infect 2003 Feb 10-14;10th: abstract no. 734
A. Zolopa1 
, C. Benson2, P. Bacchetti3, P. C. Tien3, C. Grunfeld for the Investigators of the Fat Redistribution and Metabolic Change in HIV Infection (FRAM) Study3
1Stanford Univ, Palo Alto, CA; 2Univ of Colorado, Denver; and 3Univ of California at San Francisco
BACKGROUND: Buffalo hump (BH) was one of the earliest changes in fat distribution reported in HIV infection. We assessed the prevalence of BH in HIV+ and control men (CON) in the FRAM study, then compared body composition in those with and without BH.
METHODS: We compared 421 HIV+ men between the ages of 33 and 45 years from 18 centers to 151 similar age control (CON) men from the Coronary Artery Risk Development in Young Adults (CARDIA) study. The presence of BH was determined on exam and the X and Y dimensions measured with a Gulick tape measure. MRI was performed to quantify subcutaneous adipose tissue (SAT) in lower (abdomen/back) and upper (chest/back) trunk and visceral adipose tissue (VAT).
RESULTS: BH was found on exam in 8.0% of HIV+ men and 11.3% of CON (p = 0.24, OR 0.68, CI 0.31-1.28). In HIV+ men, those with BH had higher BMI than those without BH, whereas in CON men, BMI was similar. In both HIV and CON, those with BH had higher trunk SAT and VAT measured by MRI than those without BH. However, while HIV+ men with BH had less lower trunk SAT than CON men with BH, both HIV+ and CON men with BH had similar BMI, upper trunk SAT, and VAT.
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Measures |
|
HIV+ |
CON |
p-value HIV+ vs. CON |
|
BMI (median Kg/m2) |
BH |
27.3 |
27.6 |
0.52 |
|
No BH |
24.2 |
27.0 |
<0.001 |
|
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p-value BH vs. No BH |
<0.001 |
0.21 |
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|
|
MRI trunk SAT (median L) |
BH |
7.54 |
11.3 |
0.12 |
|
No BH |
5.41 |
8.08 |
<0.001 |
|
|
p-value BH vs. No BH |
<0.001 |
0.027 |
|
|
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MRI lower trunk SAT (median L) |
BH |
3.87 |
8.00 |
0.012 |
|
No BH |
3.55 |
5.63 |
<0.001 |
|
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p-value BH vs. No BH |
0.0254 |
0.031 |
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|
|
MRI upper trunk SAT (median L) |
BH |
3.75 |
2.71 |
0.24 |
|
No BH |
1.86 |
2.30 |
<0.001 |
|
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p-value BH vs. No BH |
<0.001 |
0.059 |
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|
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MRI VAT (median L) |
BH |
3.02 |
2.83 |
0.89 |
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No BH |
1.45 |
1.75 |
0.009 |
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p-value BH vs. No BH |
<0.001 |
0.026 |
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Finally, BH averaged 2.5x larger in HIV+ (9.0 x 8.2 cm) vs CON (5.5 x 5.4 cm; each dimension p < 0.001).
CONCLUSIONS: Although BH is not more common in HIV+, it is associated with different fat distribution: HIV+ men have larger BH and similar upper trunk SAT, but less lower trunk SAT compared to CON with BH. HIV+ men with BH have higher BMI than HIV+ men without BH. In both HIV+ and CON men, BH is associated with higher VAT. BH may be a surrogate marker for VAT.
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734
Copyright © 2003 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.
