14th Conference on Retroviruses and Opportunistic Infections Los Angeles, California - February 25-28, 2007

Conf Retrovir Opportunistic Infect 2007 Feb 25-28;14:abstract no. 3b

Kevin Shianna
Inst for Genome Sci and Policy, Duke Univ, Durham, NC, US

BACKGROUND: With the completion of the HapMap project and recent technological advances, it is now feasible to perform a genome-wide screen using DNA chips that detect up to 650,000 single nucleotide polymorphisms (SNP). Many of these SNP are tagging SNP representing other closely associated variation in the genome.

CONCLUSIONS: The use of these tagging arrays will be discussed focusing specifically on genomic coverage of the specific arrays and the use of these arrays to detect deletions and duplications, commonly referred to as copy number variations (CNV). The genome-wide identification of CNV on a large scale is now possible through the use of high-density SNP based arrays. It is highly probable that some CNV will be associated with certain complex diseases or traits. Therefore, it is essential that the identification of these variants play a role in genome-wide association studies. Lastly, small-scale association studies and a SNP-based HLA typing array for use in the CHAVI host genetic studies will be discussed.

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2007-02-25
3b

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