14th Conference on Retroviruses and Opportunistic Infections Los Angeles, California - February 25-28, 2007

Conf Retrovir Opportunistic Infect 2007 Feb 25-28;14: (abstract no. 3c)

Amalio Telenti
Univ of Lausanne, Switzerland

BACKGROUND: Susceptibility to HIV-1, and the rate of disease progression reflect the influence of the genetic diversity of the virus as well as variation in host factors. The identification of relevant genetic variants provides information of interest for understanding pathogenesis, for diagnostics, and for therapeutics. Approximately 50 candidate genes have been investigated over the last 10 years, under various study designs, populations, and degree of evidence. However, only a fraction of the observed variability in the course of HIV-1 infection is explained by current knowledge. Current approaches use whole genome analysis to generate a new set of candidate genes for which no a priori knowledge exists.

CONCLUSIONS: The likelihood of using genetic data for drug development, for the analysis of vaccine response, or for clinical use depends on a concerted effort to establish evidence, to validate through clinical trials, and to generate cost-effective tools.

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2007-02-25
3c

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