Second International Congress Drug Therapy in HIV Infection 18-22 November 1994 Glasgow, UK

SEXUAL TRANSMISSION OF ZIDOYUDINE RESISTANT HIV-1

David A.Cooper^{1, 2}, A. Irnrie¹,and the Sydney Primary HIV
Infection Study Group. ¹ Centre for Immunology, St Vincent's Hospital, Sydney; ² National Centre in HIV Epidimiology and Clinical Research. University of NSW, Sydney, Australia.

Int Cong Drug Therapy HIV 1994 Nov 18-22;2:Abstract No. 5.3
AIDS 1994, Vol. 8 (Suppl. 4);S4

HIV-1 with decreased in vitro susceptibility to zidovudine (ZDV) may be isolated from patients on prolonged therapy, We examined the frequency with which ZDV resistant variants of HIV -I were isolated from 48 homosexual men with primary HIV -1 infection (PHI), as well as from 8 sexual partners. Resistance to ZDV was assessed using PBL susceptibility assays and selective PCR for mutation at codon 215 of the viral RT, ZDV -resistant HIV -I was isolated from 5 seroconverters, as well as from the sexual partner of one of these patients.This prevalence of ZDV-resistant HIV-1 in acute PHI (5/48,10.4%) is not significantly different at the 0.05 level from the proportion of people living with HIV-1 infection in Australia who were estimated to have developed zidovudine resistance.

In one seroconverter, drug-resistant virus did not persist for more than 3 months following transmission, despite limited ZDV therapy for symptoms of PHI. 12 months after seroconversion this patient is clinically well, with category A I HIV disease. The long term clinical consequences of primary infection with drug resistant variants of HIV-1 remain to be determined.

1994-11-18
5.3

Originally published in AIDS Volume 8, Supplement 4 and hosted with permission of the publisher Lippincott Williams & Wilkins, 250 Waterloo Road, London, SE1 8RD, UK. Tel: +44 (0)20 7981 0700 Fax: +44 (0) 7981 0701

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