Sixth International Congress Drug Therapy in HIV Infection 17-21 November, 2002 Glasgow, UK

[ABSTRACT:] The use of therapeutic drug monitoring (TDM) has received an increasing amount of interest during the last years. Some national guidelines (e.g. France, United Kingdom, The Netherlands) have now included TDM as part of diagnostic set up for a patient, but development of TDM in other countries still in its infancy. TDM may be particularly useful in the following situations:

• Virological failure
• Intoxication
• Drug – drug interactions
• Nonadherence

So far, there has been no consensus among pharmacologists about the way of using TDM of antiretroviral agents. There are numerous studies showing that drug levels are related to antiviral effect, but this has not yet resulted in a consensus on a therapeutic range for these agents. Nevertheless, data have now been presented of 2 randomized controlled clinical trials showing TDM of nelfinavir and indinavir in treatment-naïve patients improves therapeutic outcome of these patients over 1 year. In contrast, disappointing results have been presented of TDM in second-line regimens, but these studies had significant methodological flaws to draw any conclusions. generally expected, however, that use of TDM in second-line or salvage regimens (i.e. when drug resistance may be present) will only be useful if information is known regarding resistance (the IQ concept).

Several studies are now underway that will give us information how to TDM in the near future.

Presenting author: David Burger

Download Conferences Abstracts

1 University Medical Centre St Radboud, Nijmegen, Netherlands

2002-11-17
PL8-1

Copyright © 2002 - The Gardiner-Caldwell Group, Ltd.. All Rights Reserved. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Sixth International Congress on Drug Therapy in HIV Infection, c/o The Gardiner-Caldwell Group Ltd, part of The Thomson Corporation, Peakside House, Alder Court, Tytherington Business Park, Tytherington, Cheshire SK10 2XG, UK - Tel: +44 (0)1625 668000, Fax: +44 (0)1625 668121 Email: hiv6@gardiner-caldwell.com

This information is designed to support, not replace, the relationship that exists between you and your doctor. ©1980, 2005. AEGiS.