Seventh International Congress on Drug Therapy in HIV Infection


Glasgow, UK - 14-17 November 2004

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[KL3] HIV host genetics: different people , different disease

Int Cong Drug Therapy HIV 2004 Nov 14-18;7:Abstract No. KL3 Amalio Telenti
Institute of Microbiology, University of Lausanne, Lausanne, Switzerland

Physicians are confronted to the diversity of susceptibility to infectious diseases or response to medication among patients. Much work has been done to characterize the virulence factors of pathogens, while less is known about the host (human) factor. Two unrelated people share about 99.9% of their DNA sequences, while the remaining 0.1% contains the genetic variants that influence how they differ in their risk of disease or response to drugs. Current developments in human genomics hold particular interest for the field of antiretroviral therapy because of the growing choice of drugs, the prevalence of acute of cumulative drug toxicities, and the evidence for significant inter-individual differences in pharmacokinetics and drug response. Pharmacogenetics and pharmacogenomics, toxicogenetics and immunogenetics are the disciplines that are expected to deliver the future personalized medicine. This endeavor requires means to identify genes that are variant, and demands that genetic variants undergo biological and clinical validation. Implementation depends on obtaining a complete picture of the complex trait (multigene) nature of many clinical phenotypes. Detection needs the appropriate laboratory techniques, in the context of ethical limits to genetic testing.

KEYNOTE LECTURES

2004-11-14
KL3

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