Eighth International Congress on Drug Therapy in HIV Infection Glasgow, UK - 12-16 November 2006

Int Cong Drug Therapy HIV 2006 Nov 12-16;8:Abstract No. PL2.1

John Connolly
UCL Centre for Nephrology, Royal Free Hospital, Pond St, London

PURPOSE OF THE STUDY: HIV is associated with a wide spectrum of renal disease. Viral infection gives rise to a collapsing glomerulopathy (HIVAN) in susceptible patients which may be responsive to antiretroviral therapy (ART). HIV is also associated with a variety of immune complex glomerular diseases in which the role of ART is less clear. Antiretroviral therapy itself gives rise to often dramatic renal complications including acute renal failure, the Fanconi syndrome and renal stones. Acute renal failure is common in HIV and multifactorial, related to infection, drug toxicity and volume depletion. As individuals with HIV live longer and develop age related chronic disease the incidence of chronic kidney disease (CKD) will likely increase. The epidemiology of renal disease in HIV is unknown and few population based studies have addressed proteinuria or reduction in GFR, the hallmarks of CKD. Reduction in GFR and the presence of proteinuria are independent risk factors for cardiovascular disease which is of added significance in a HIV population already at increased risk. With the widespread introduction of eGFR as a measurement of kidney function and the establishment of national guidelines for management of CKD a coherent strategy is needed for HIV patients in whom the manifestations of renal disease are so diverse.

Plenary Session: Open Papers

2006-11-12
PL2.1

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