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1st International AIDS ConferenceAtlanta, Georgia, U.S.A. - April 14-17, 1985 |
Cite as: Int Conf AIDS. 1985 Apr 14-17;1: Abstract No. xx
| S1A | THE USE OF INTERFERON (IFN) IN THE TREATMENT OF ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) RELATED KAPOSI'S SARCOMA (K.S.). Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S1A) Adan Rios, PWA Mansell, G Newell, J Reuben, EM Hersh, and JU Gutterman. Further studies are indicated to improve the therapy of this disease. |
| S1B | VINBLASTINE THERAPY OF AIDS-RELATED KAPOSI'S SARCOMA (KS). Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S1B) P Volberding, D Abrams, J Ziegler, M Conant, K Vranizan, K Kaslow. Because of the risk of chemotherapy associated immune suppression, efforts to treat KS have focused on single-agent chemotherapy. Vinblastine (VLB) is an attractive agent because of minimal toxicity and documented activity in non-AIDS associated KS. Thirty-eight patients with AIDS-related KS were treated with weekly in |
| S1C | THERAPY OF AIDS-RELATED KAPOSI'S SARCOMA (KS) WITH ICRF-159. Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S1C) Paul A Volberding, D Abrams, L Kaplan, M Conant, G Carr. Because ICRF-159 is a very active agent in non-AIDS-related African KS, it was used here in patients with all stages of KS associated with AIDS. The drug dose and schedule were the same as in previous reports from Africa. Patients received Igm/m2/day x 3 orally every 3 weeks. 23 patients were enrolled. The mean age was |
| S1D | A TRIAL OF ANTIMONIOTUNGSTATE (HPA73) IN PATIENTS WITH AIDS OR PROLONGED GENERALIZED LYMPHADENOPATHY. Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S1D) Willy Rozenbaum, D Dormont, E Vilmer, B Spire, F Barre & L Montagnier & J C Chepmann. Patients with AIDS or related syndrome were selected by the detection of antibodies to Lymphadenopathy Associated Virus (LAV) and by the isolation of LAV from cultured peripheral blood cells. Two types of treatment with Tungsto-antimoniate (HPA33) were scheduled: IV bolus or IV infusion for 3 hrs per day during 15 days |
| S2A | SURVEILLANCE FOR AIDS IN CHILDREN. Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S2A) Martha F Rogers, PA Thomas, RM Selik, AM Hardy, MC Rogers, WM Morgan. Since the Centers for Disease Control began surveillance for AIDS in 1981, 72 cases of AIDS in children under 13 years of age have been reported. The childhood cases differ epidemiologically from those in adults: 74% (53) of the 72 children are Black or Hispanic, compared with 39% of adults; and 58% (42) of the childre |
| S2B | MOTHERS OF INFANTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS): OUTCOME OF SUBSEQUENT PREGNANCIES. Int Conf AIDS 1985 Apr 14-17; 1:21 (abstract no. S2B) Gwendolyn B Scott, M Fischl, N Klimas, M Fletcher, G Dickinson, and W Parks. Sixteen mothers of infants with AIDS or an AIDS related complex (ARC) were followed for evidence of clinical or immunological abnormalities. All but one mother were clinically well at the time of birth of their first child with AIDS. However, all mothers had immune dysfunction with inverted T-cell ratios (15/16) or mar |
| S2C | EPIDEMIOLOGICAL FEATURES OF PEDIATRIC ACQUIRED IMMUNE DEFICIENCY SYNDROME IN NEW JERSEY. Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S2C) James Oleske, M Zabala, A Minneror, T Denny, R Bobila, V Joshi. Our first group of pediatric AIDS patients was initially reported in March 1983. These children were born in high-risk households; either the offspring of IV drug addicted mothers or their mother was a sexual partner of an IV drug user. Since 1979 a total of 34 infants or children belonging to high-risk groups have bee |
| S2D | IMMUNODEFICIENCY AND HTLV-III/LAV SEROLOGY IN HETEROSEXUAL PARTNERS (HP) OF AIDS PATIENTS (PTS). Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S2D) CA Harris, C Cabridilla, M Robert-Guroff, RS Klein, GH Friedland, VS Kalyanaraman. A radioimmunoprecipitation assay (RIP) to a core protein (p25) of LAV, a Western blot (WB) against p41 and/or p24 of HTLV-III after an ELISA screening and an ELISA against HTLV-III/LAV CDC451 virus were each used to test for retroviral serum antibiodies in 25 couples consisting of index Pts with AIDS (21) or AIDS-relat |
| S2E | HOUSEHOLD TRANSMISSION OF HTLV-III IN ZAIRE. Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S2E) Jonathan M. Mann, H Francis, BM Kapita, K Ruti, T Quinn, JW Curran. Preliminary information, investigation of small clusters of AIDS patients in Africa, and analogies to other diseases like Hepatitis B have suggested that non-sexual transmission of HTLV-III of infection may occur in household settings. The Project SIDA, a collaborative international project studying AIDS in |
| S3A | NUCLEOTIDE SEQUENCE OF LAV. Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S3A) Marc Alizon, Pierre Sonigo, Olivier Danos, Stewart Cole, and Simon Wain-Hobson. The complete 9193 nucleotide sequence of LAV has been determined. In keeping with its unusual cytopathic effect in vitro, the genetic organization of the genome is original. In addition to to encoding the viral gag, pol and env genes the virus carries at least two other open reading frames called Q and F. Orf Q overlap |
| S3B | GENETIC STRUCTURE OF AN AIDS-ASSOCIATED RETROVIRUS (ARV): DNA SEQUENCE AND EXPRESSION OF CLONED VIRAL GENES. Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S3B) Paul A Luciw, R Sanchez-Pescador, M Power, P Barr, K Steimer, J Levy, D Dina. Epidemiological studies support a causal role for a closely related group of retroviruses in the human acquired immunodeficiency syndrome (AIDS). We have sequenced molecular clones of the DNA from one such virus isolate, ARV-2, to establish the genetic structure of a representative AIDS retrovirus. Proviral DNA of ARV- |
| S3C | NUCLEIC ACID STRUCTURE AND EXPRESSION OF THE HUMAN AIDS/LYMPHADENOPATHY RETROVIRUS. Int Conf AIDS 1985 Apr 14-17; 1:22 (abstract no. S3C) Mark Muesing, Douglas Smith, C Cabradillo, Charles Benton, Laurence Lasky, Daniel Capon. The 9,213 nucleotide structure of the AIDS/lymphadenopathy virus has been determined for one of the integrated proviruses present in the H9/HTLV-III cell line and for a complete set of overlapping cDNAS representing the viral RNA of distinguishable isolate(s) also present in H9/HTLV-III cells. These results demonstrate |
| S3D | CHARACTERIZATION OF THE GENOME OF HTLV-III. Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S3D) Lee Ratner, William Haseltine, R Patarca, KJ Livak, B Starcich, SF Josephs. DNA sequence analysis of cloned HTLV-III proviruses reveals an organization of the genome unusual for retroviruses. While the gag and pol genes exhibit relatively little variation in organization as compared to HTLV-I, the 3 end of the genome is markedly different from that of HTLV-I. It is likely that the novel potent |
| S3E | TRANSCRIPTIONAL TRANS-ACTIVATION OF THE LONG TERMINAL REPEATS OF MEMBERS OF THE HTLV-BLV RETROVIRAL FAMILY. Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S3E) William A Haseltine, J Sodroski, C Rosen, F Wong-Staal, R Gallo. Transcription directed by the long terminal repeat (LTR) elements of HTLV-I, HTLV-II, HTLV-III and bovine leukemia virus (BLV) is markedly increased in trans by factors present in infected cells. The viral-associated trans-acting factors exhibit preference for the LTR type of the infecting virus, suggesting that a vira |
| S3F | TRANS-ACTING TRANSCRIPTIONAL ACTIVATION: SIMILARITIES BETWEEN BOVINE LEUKEMIA VIRUS AND HUMAN TLYMPHOTROPIC VIRUSES. Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S3F) A Srinivasan, V Kalyanaraman, R Narayanan, C Calbradilla, R Anand, D Francis, J Curran. Bovine leukemia virus (BLV), an exogenous type C retrovirus, induces enzootic bovine leukosis in the bovine species. BLV, in genomic organization, has closer resemblance to the retorviruses belonging to the family of human T-lymphotropic viruses (HTLV) and has partial amino acid sequence homology to HTLV I and II subgr |
| S4A | PNEUMOCYSTIS CARINII PNEUMONIA IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S4A) Stuart M Garay, M Belenko, F Schwiep, D Kamelhar, J Green. Between 11/80 and 12/84 205 AIDS patients presented with PCP: drug abusers-85, homosexual men-105, heterosexual females without drug abuse-3 and transfusion related-2. Bronchoscopic diagnosis of PCP was made in all but 3 cases: transbronchial biopsy (96%) and/or alveolar lavage (75%). Touch imprints were positive in 79 |
| S4B | SIGNIFICANCE OF PERSISTENCE OF P. CARINII AFTER COMPLETION OF TREATMENT Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S4B) Philip Michael, H Brodie, M Wharton, C Bryant, C Wofsy, P Hopewell. The optimum duration of treatment for P. carinii pneumonia ( PCP ) in patients (pts) with AIDS has not been established. It has been suggested that persistence of organisms after 3 weeks of therapy is an indication to prolong treatment. To determine if this was correct, we performed bronchoscopy after 3 weeks of therap |
| S4C | TOXICITY OF INTRAVENOUS (IV) PENTAMIDINE ISETHIONATE (PI) IN PATIENTS WITH AIDS TREATED FOR PNEUMOCYSTIS CARINII PNEUMONIA (PCP). Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S4C) Jose Dryjanski, B Polsky, JWM Gold, EM Bernard, AE Brown, D Armstrong. The high incidence of adverse reactions to sulfamethoxazole-trimethoprim (SXT) in AIDS patients has resulted in an increased use of PI. The intramuscular (IM) route has been recommended due to the reported increase in adverse reactions with PI given by IV bolus. PI-IV has been used in 42 episodes of |
| S4D | HISTOPATHOLOGIC LYMPH NODE CHANGES AND THEIR CORRELATION TO CLINICAL AND IMMUNOLOGIC FINDINGS IN DANISH HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S4D) Gorm Pallesen, J Gerstoft, LR Mathiesen, S Brask, E Dickmeiss, P Platz. Lymph nodes (LNs) from 30 homosexual men with lymphadenopathy syndrome (LAS) were studied by microscopy and monoclonal antibody immunohistologic staining to relate morphologic features with clinical and immunologic data. Changes of LNs were classified according to 3 stages that might be associated with progression of d |
| S5A | A CASE-CONTROL STUDY OF RISK FACTORS FOR AIDS IN SAN FRANCISCO. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S5A) Dennis Osmond, AR Moss, P Bachetti, P Volberding, F Barre-Sinoussi, J-C Chermann. In 1983-84 we interviewed 246 successively-diagnosed, CDC-defined, homosexual AIDS patients in San Francisco, 44% with KS only and 56% with 0I or both diseases. 165 patients were success-fully matched with randomly-chosen homosexual men picked as neighborhood controls; 166 were matched to VD clinic controls. We report |
| S5B | RISK FACTORS FOR HTLV-III/LAV SEROCONVERSION IN A COHORT OF HOMOSEXUAL MALE CLINIC PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S5B) William W Darrow, P O'Malley, HW Jaffe, JE Getchell, RH Byers, DF Echenberg. In a sample of homosexual men, randomly selected from a cohort formed in 1978-1980 to study hepatitis B virus (HBV) infections, we tested stored sera collected when men entered the cohort and sera collected in 1983-1984 for antibodies to HTLV-III/LAV by an enzyme-linked immunosorbent assay. Of 362 men who were initiall |
| S5C | DISEASE MANIFESTATION AMONG HOMOSEXUAL MEN WITH ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS): A POSSIBLE ROLE OF NITRITES IN KAPOSI'S SARCOMA. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S5C) Harry W Haverkos, PF Pinsky, DP Drotman, DJ Bregman. This analysis was undertaken to determine which, if any, variables determine the major disease manifestation for AIDS patients. CDC staff had conducted interviews with 87 homosexually active men with AIDS as part of previous epidemiologic investigations. The raw data from these interviews were aggregated and reanalyzed |
| S5D | LAV/HTLV-III INFECTIONS AND AIDS AMONG HOMOSEXUAL MEN IN AND AROUND AMSTERDAM. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S5D) Roeland A Coutinho, W Krone, N Albrecht-Van Lent, J Van Der Noordaa, J Goudsmit. A group of 800 homosexual men in and around Amsterdam participated in an efficacy trial with a heat-inactivated hepatitis B vaccine, which was conducted between November 1980 and December 1982. The first and the last bloodsample of a large part of the participants were tested for the presence of IgG antibodies to LAV/H |
| S6A | THE MAJOR ENVELOPE GLYCOPROTEIN OF LAV (GP110): IDENTIFICATION, ANTIGENICITY AND NEUTRALIZING CAPACITY OF SPECIFIC ANTIBODIES. Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S6A) Francois Clavel, B Krust, D Klatzmann, F Barre-Sinoussi, JC Chermmann and L Montagnier. Using 35S-cystein labelling and SDS-PAGE analysis of LAVI infected cells supernatant lysates, we have characterized a 110K protein, associated with the virus band in zonal centrifugation, and absent in supernatants of uninfected cells. Its glycoprotein nature was assessed by 1 C-glucosamine labelling, specific binding |
| S6B | ISOLATION AND CHARACTERIZATION OF A STRAIN OF HTLV-III/LAV FROM A HEMOPHILIA PATIENT WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S6B) VS Kalyanaraman, JP Getchell, TL Chorba, RB Ramsey, R Narayanan, DP Francis. We have characterized a human T-lymphotropic virus which was isolated from the cultured T-lymphocytes of a hemophilia patient with AIDS. This virus isolate was designated HTLV-III/LAV (CDC 451). By electron microscopic examination this virus is very similar to HTLV-III and LAV. In competition radioimmunoassays HTLV-I a |
| S6C | T-LYMPHOCYTE T4 MOLECULE BEHAVES AS THE RECEPTOR FOR HUMAN RETROVIRUS LAV. Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S6C) D. Klatzmann, E Champagne, JC Gluckman and L Montagnier. Lymphadenopathy associated virus (LAV)displays selective tropism for a subset of T lymphocytes defined by the surface glycoprotein termed T4. Such a tropism may be controlled at the genomic level by regulatory sequences or at the membrane level, requiring the interaction of a specific cellular receptor with the virus e |
| S6D | ENVELOPE PROPERTIES OF THE AIDS RETROVIRUS. Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S6D) Angus Dalgleish, P Clapham, R Cheingsong-Popov, M Exley, RA Weiss. Ile have used biological assays of the AIDS retrovirus to investigate the interaction of the envelope glycoprotein with the host imune system. Our findings demonstrate that (1) the T4 antigen is an essential cell surface component of the virus receptor, (b) infected individuals whether healthy or immunocompromised are |
| S6E | RECEPTOR MEDIATED PROPAGATION OF HTLV-III IN HUMAN T CELLS. Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S6E) Mikulas Popovic, D Mann, E Read-Connole, C Neuland, RC Gallo. Permanent human T cell lines were studied for infection and propagation of HTLV-III. The virus infects those cell lines which bear the OKT4 and Leu 3a antigens. In early infection when the virus attachment to cell surface takes place reduction of OKT4a and Leu 3a epitopes was found but not OKT4. The OKT4 gradually decr |
| S7A | FANSIDAR PROPHYLAXIS FOR PNEUMOCYSTIS CARINII PNEUMONIA (PCP). Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S7A) David Hardy, PR Wolfe, MS Gottlieb, S Knight, R Mitsuyasu, LS Young. PCP is the most frequently occurring opportunistic infection in patients with the Acquired Immunodeficiency Syndrome (AIDS). Most patients respond to co—trimoxazole (CTM) and/or pentamidine therapy during the initial episode. Relapses of PCP in non—prophylaxed patients are common (30—507.). |
| S7B | DIAMINODIPHENYLSULFONE (DAPSONE) AS TREATMENT FOR PNEUMOCYSTIS CARINII PNEUMONIA IN AIDS PATIENTS IN COMBINATION WITH TRIMETHOPRIM. Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S7B) S. Richardson, M Fanning, J Brunion, I Salit, S Read, F Shepherd. The high frequency of adverse reactions to conventional therapy of Pneumocystis carinii pneumonia ( PCP ) in AIDS patients warrants a search for an efficacious, less toxic agent. Dapsone has been shown to be effective in a rat mxlel. We used Dapsone (100 mgs p.o./d.) and Trimethoprim (20 mgs/kg/d) for two weeks in a pa |
| S7C | BACTEREMIA AND FUNGEMIAS IN PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S7C Estella Whimbey, T Kiehn, P Brannon, A Blevins, J Gold, D Armstrong. Forty episodes of bacterania and fungemia have occurred in 34 of 295 patients with AIDS cared for at MSKCC. There were 4 types of infections. I. Infections associated with a T-cell immunodeficiency [Salmonella (6), Cryptococcus (5), Listeria (2)]. II. Nosoearial infections [C. albicans (4), S. epid. (4), non-Salmonell |
| S7D | THE ACQUIRED IMMUNODEFICIENCY SYNDROME AND DISSEMINATED, HISTOPLASMOSIS IN A NONENDEMIC AREA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S7D Catherine B Small, D Hewlett, FP Duncanson, T Lenox, GP Wormser. Six patients in high-risk groups for AIDS developed disseminated histoplasmosis while long-term residents of the New York City (NYC) area. All were born in Puerto Rico (PR). All were intravenous drug abusers and 1 was homosexual. Six had oral thrush , 2 had Pneumo |
| S7E | EVALUATION OF DHPG AGAINST CYTOMEGALOVIRUS INFECTION IN AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S7E WL Drew, S Mehalko, H Brodie, J Mills, R Neger, J O'Donnell. Four homosexual men with AIDS and culture positive CMV infection were treated with DHPG, 5 mgn/kg. I.V. 3 times daily for at least 10 days. Antiviral effect was demonstrated as follows: CMV Titers (PFU/ml) in urine at weekly intervals Patient/Dx Pre Rx 1 2 3 4 5 6 7 8 9 35 1. Retinitis 162 55 |
| S7F | RECONSTITUTION OF T-CELL FUNCTION IN AIDS AND ARC PATIENTS BY USE OF THE ENDOGENOUS, LEUKOCYTE-DERIVED IMMUNOMODULATOR, IMREG-1 A. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S7F Arthur Gottlieb, JL Farmer, A Levine, P Gill, M Flaum, and MS Gottlieb. IMREG-1, a low molecular weight immunomodulator isolated from normal human leukocytes, has previously been reported to augment and accelerate skin test responses in normal human subjects, and to enhance in vitro production of LIF, MIF and interleukin-2 ( IL-2 ) by the human helper T cell subset, suggesting utility of t |
| S8A | THE SPREAD OF HTLV-III INFECTION AMONG THE SEXUAL CONTACTS OF HTLV-III INFECTED HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S8A Sirkka-Liisa Valle, C Saxinger, A Ranki, J Suni, J Antonen and K Krohn. The sexual contacts of 18 HTLV-III infected homosexual males in a low-incidence area of AIDS were repeatedly studied for HTLV-III antibodies during a follow-up of 10-18 months. Two of the index cases had AIDS, 3 ARC, 5 LAS, 3 enlarged lymph nodes and 5 were asymptomatic. Out of their sexual contects, 41 have been exami |
| S8B | LYMPHADENOPATHY: UPDATE OF A 40 MONTH PROSPECTIVE STUDY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S8B Donald I Abrams, TP Mess, and P Volberding. Two hundred homosexual men with persistent diffuse lymphadenopathy of greater than 6 months duration involving 2 or more extra-inguinal sites have been enrolled in a natural history study since November 1981. Seroepidemiologic evidence from studies of the lymphotropic retroviruses confirms that the syndrome is indeed a |
| S8C | A PROSPECTIVE EVALUATION OF THE NATURAL HISTORY OF HTLV-III INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S8C Robert T, Schooley, MS Hirsch, T Flynn, R Byington, DD Ho, CA Andrews. This study further defines the natural history of HTLV-III infection, and may be of use in planning treatment trials and in patient counseling. |
| S8D | HTLV-III SEROPOSITIVITY AND ITS RELATIONSHIP TO DISEASE IN A PROSPECTIVE STUDY OF HOMOSEXUAL MALES. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S8D Michael Marmor, W Elsadr, S Zolla-Pazner, M Lyden, D Bebenroth, Sh Weiss. The cumulative incidence of AIDS or suspected AIDS was 0% (0/23) among HTLV-III seronegative subjects, and 71% (12/17) among HTLV-III seropositive subjects. |
| S8E | CANCER TRENDS IN A POPULATION AT RISK OF AIDS: 1973-82. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S8E RJ Biggar, J Horm, JH Lubin, JJ Goedert, MH Greene, JF Fraumeni. Recent case reports have linked AIDS with some cancers other than Kaposi's sarcoma (KS). Using the Surveillance, Epidemiology and End Results (SEER) program, we compared with morbidity odds ratio (OR) for selected cancer sties in pre-and post-AIDS periods. |
| S9A | GENOMIC DIVERSITY OF THE AIDS VIRUS, HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S9A GM Shaw, BH Hahn, SZ Salahuddin, P Markham, M Popovic, RC Gallo, and F. Wong-Staal. We conclude that: (1) genomic diversity is a characteristic feature of HTLV-III and occurs to varying degrees in different viral isolates, (ii) a single patient can be infected with more than one form of the virus simultaneously, and (iii) no particular restriction cleavage pattern could be correlated with a particular disease state (e.g., AIDS, ARC, or healthy carrier state). |
| S9B | CHARACTERIZATION OF VIRAL SPECIFIC NUCLEIC ACID IN HUMAN CYTOPATHIC RETROVIRUS INFECTED CELLS. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S9B Steven Benn, T Folks, A Rabson, M Lightfoote, MD Hogganm, M Martin. The population of Leu 3- cells that appears late in infection thus represents a model of human cytopathic retrovirus latency. |
| S9C | DETECTION OF RARE HTLV-III-INFECTED CELLS IN PRIMARY TISSUE FROM AIDS PATIENTS BY IN SITU HYBRIDIZATION. Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S9C ME Harper, LM Marselle, RC Gallo and F Wong-Staal. Hybridization of a probe control specific for A DNA to AIDS cells or the H9/HTLV-IIIB cell line resulted in no label. This hybridization method, which uses 35S-RNA probes, exhibits high sensitivity and specificity for viral sequences, and has detected viral RNA in a significant percentage of cases so far examined. It is also evident from these and Southern blot experiments that the number of HTLV-III-infected cells in AIDS or ARC primary tissue is very low and that lymph node enlargement in patients with lymphadenopathy is not due to proliferation of HTLV-III-infected lymphocytes. |
| S9D | CELLULAR REQUIREMENTS FOR HTLV-III/LAV REPLICATION. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9D J Steven Mcdougal,SP Cort, JKA Nicholson, D Cross, A Mahle, J Sligh. Results in macroculture with separated cell populations were confirmed in a microculture infectivity assay system under conditions of both constant cell concentration with limiting virus input and constant virus inoculum with limiting cell input. Although we could not directly demonstrate virus replication in monocytes, these cells inoculated with HTLV-III/LAV are capable of transmitting virus Lo PHA-stimulated MNC. |
| S9E | CLINICAL AND IMMUNOLOGICAL PREDICTORS OF HTLV-III/LAV INFECTION IN GAY MEN. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9E J Allen McCutchan, P Spechko, G Boss, F Jensen. 64% of gay men with one sign or symptom suggestive, but not diagnostic, of ARC and only 26% of asymptomatic gay men with immune abnormalities have LAV-Ab.3 of 4 gay men without immune abnormalities who had LAV-Ab were IgM +. We conclude 1) one sign or symptom of ARC is a better predictor of infection with LAV than asymptomatic immune abnormalities and 2) early in LAV infection persons are IgM+, but are often asymptomatic and sometimes without immune abnormalities. |
| S9F | DETECTION OF HUMAN T-CELL LYMPHOTROPIC VIRUS-III ANTIBODIES BY AN ENZYME LINKED IMMUNOSORBENT ASSAY. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9F Anne J Bodner, DS Watson, DA Brusini, AE Williams, RR Redfield, NA Stombaugh. Data will be presented showing good correlation between this ELISA assay and data from Western Blot analyses. The ELISA test is currently being clinically evaluated at several blood research centers in the United States. |
| S9G | WESTERN BLOT ANALYSIS OF HUMAN T-CELL LYMPHOTROPIC VIRUS-III PROTEINS USING AN AVIDIN-BIOTIN SYSTEM. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9G Steve S Alexander Jr, C Tal, RL Ting, AJ Corrigan, AJ Bodner, DW Julien. A Western Blot system using Biotin-Avidin detection has been utilized to study the composition of viral proteins from Human T-Cell Lymphotropic Virus-III (HTLV-III). Purified HTLV-III viral proteins are electrophoresed on 12% SDS slab gels and electro-transferred onto nitro cellulose sheets. |
| S9H | COMPARISON OF THREE ASSAYS TO DETECT ANTIBODY TO HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9H Jane P Getchell, JR Allen, B Kilbourne, C Bohan, DR Hicks, VS Kalyanaraman. Sensitive and specific assays for antibody to HTLV-III are essential for studies of AIDS and for screening in blood banks. |
| S9I | SEROLOGICAL EVIDENCE LINKING THE AIDS-ASSOCIATED RETROVIRUSES (ANV) TO AIDS AND RELATED CONDITIONS IN THE UNITED STATES. Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9I Lawrence S Kaminsky, C Foxall, and JA Levy. We have developed a highly sensitive indirect immunofluorescent assay (IFA) for detection of antibodies to the AIDS-associated retroviruses (ARV). It uses HUT-78 cells infected with ARV-2 which grows to high titer in these cells. Our results indicate that all patients with AIDS tested thus far (133/133) have antibodies to the agent. |
| S9J | EVALUATION OF THE SEROLOGICAL PARAMETERS OF HTLV-III ANTIBODIES IN NORMAL AND "AIDS"-RISK DONORS BY ELISA. Int Conf AIDS. 1985 Apr 14-17;1:29 Abstract No. S9J C Saxinger, G Lange-Wantzin, K Krohn, G Biberfeld, A Ranki, R Gallo. A series of donor groups from Denmark, Finland and Sweden were tested for serum antibodies to HTLV-III: including, normal donors, asymptomatic male homosexuals, male homosexuals who were symptomatic but lacking complete CDC criteria, with LAS, and with AIDS. |
| S9K | OCCURRENCE OF BIOLOGICAL FALSE POSITIVES (BFP) IN THE ELISA FOR HTLV-III ANTIBODY DETECTION. Int Conf AIDS. 1985 Apr 14-17;1:29 Abstract No. S9K Judith Britz, P Golus, D Zimmerman, FK Mundon, E LaBrec, GA Bush. The occurrence of biological false positives (BFP) in the ELISA for HTLV-III antibody detection presents a sensitive situation where a specific positive for antibodies to HTLV-III needs to be clearly differentiated from any false positive results. In the development of an HTLV-III ELISA test, a control plate prepared from a concentrate of the uninfected H9 cell line was evaluated. |
| S9L | SIMPLE, SAFE AND SENSITIVE METHODS FOR ANTIBODY TO HTLV III. Int Conf AIDS. 1985 Apr 14-17;1:29 Abstract No. S9L William J Jesson, MS Pereira, PP Mortimer & BJ Cohen. Two anti-HTLV III methods were developed: competitive radioimmunoassay (RIA) and immunofluorescence (IF). Persistently HTLV III-infected cells from the line HT/H9/3 (given by RC Gallo) were pelleted, frozen and thawed, and treated with 0.25% B propriolactone and 0.1% tween 20. This antigen was bound to 6mm polystyrene beads by immunoglobulin B prepared from the heat inactivated sera of patients with high anti-HTLV III titres. |
| S9M | INDIRECT FLUORESCENT ASSAY (IFA) AS AN ALTERNATIVE TO WESTERN BLOT (WB) FOR HTLV-III ANTIBODY DETERMINATION. Int Conf AIDS. 1985 Apr 14-17;1:29 Abstract No. S9M Francis K. Mundon, RP Stone, J Britz, PA Goluss, DH Zimmerman and GA Bush. A study was undertaken to determine the usefulness of an IFA as a confirmatory test to the ELISA for HTLV-III antibody determinations. One hundred and thirty one ELISA repeatable positive samples and 43 ELISA negative samples were coded and tested by IFA. a |
| M-1 | RELATIONSHIP BETWEEN CELLULAR IMMUNODEFICIENCY AND RESPONSE TO HEPATITIS B VACCINE IN HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:30 Abstract No. M-1 AC Collier, L Corey, JD Meyers, VL Murphy, HH Handsfield. Skin test reactions to 4 antigens were not related to vaccine response. Correlation of these results with antibody to LAV/HTLV-III is pending, and analysis of the response after the final dose of vaccine awaits completion of the protocol by additional subjects. Preliminarily, it appears that failure to respond to hepatitis B immunization is correlated with sexual activity level and may result from subclinical cellular immunodeficiency. |
| M-2 | HUMORAL IMMUNE ABNORMALITIES IN TWO SOUTH FLORIDA ACQUIRED IMMUNODEFICIENCY SYNDROME RISK GROUPS. Int Conf AIDS. 1985 Apr 14-17;1:30 Abstract No. M-2 Nancy G Klimas, O Torres, G Silveira, MA Fischl, MA Fletcher. Previously we reported elevated Forssman antibody (FA), in AIDS and suggested its determination as a screen for polyclonal B cell stimulation (Clin.Res. 32:350A). We tested the sera of 91 IV drug abusers (collected from 1979-1982, immediately prior to the current AIDS outbreak in this population) snd the sera of 86 healthy Haitians (collected from 1983-1984, at employee physicals or from parents at a well baby clinic) for humoral abnormalities. |
| M-3 | THE FAILURE OF AIDS LYMPHOCYTES TO RESPOND TO ANTIGEN MAY NOT RESULT SOLELY FROM THE LOW NUMBER OF HELPER CELLS. Int Conf AIDS. 1985 Apr 14-17;1:30 Abstract No. M-3 Fred T Valentine, PD Brick. The low number of cells with helper surface phenotype (HC) plays a major role in the depressed CMI of AIDS. To determine whether a qualitative abnormality of AIDS lympho. also exists, the max. prolif. response to PPD, Candida or CMV Ag of cells from 50 AIDS pts. with a range of %HC (0-45) or of HC:SC ratios (0.1 to 1.0), were compared with the responses of mixtures of subpopulations of nl lympho artificially constructed so that they contained low numbers of HC (down 5%) and low HC:SC ratios (down to 0.2). |
| M-4 | FUNCTIONAL STUDIES OF LYMPHOCYTE SUBPOPULATIONS FROM AIDS PATIENTS AND CONTROLS IN THE LYMPHOCYTE TRANSFORMATION TEST (LTT). Int Conf AIDS. 1985 Apr 14-17;1:30 Abstract No. M-4 B Hoffman, N Ødum, L Fugger, P Platz, B Jakobsen, JO Nielsen. We have studied the response of the T4- or T8-positive subsets from controls, AIDS, and pre-AIDS ptt and found, that T8-negative peripheral blood mononuclear cells(PBMC) from controls responded normally to mitogens and antigens, whereas T4-negative PBMC showed mitogen responses of about 50%. TB-negative PBMC from AIDS and pre-AIDS ptt have decreased mitogen responses in LTT, even when concentrated to contain normal numbers of T4 cells( 20,000 per well), and T4-negative cells do not respond at all. |
| M-5 | IMMUNE COMPLEXES (IC) IN AIDS: RELATIONSHIP TO DISEASE MANIFESTATION, RISK GROUP, IMMUNOLOGIC DEFECT, AND HTLV-III/LAV SEROPOSITIVITY. Int Conf AIDS. 1985 Apr 14-17;1:30 Abstract No. M-5 Marjorie Hubbard, JS Mcdougal, JKA Nicholson, BM Jones, D Fishbein, HW Jaffe, JR Kaplan, TJ Spira, BL Evatt. IC were dedicated the staphylococci binding assay in sera from 89% of 162 AIDS patients,93% of 118 homosexual with lymphadenopathy, and risk group controls (54% of 88 homosexual men, 41% of 17 Haitians, and 89% of 55 hemophiliacs). |
| M-6 | ANTIBODIES TO INDIVIDUAL VIRAL STRUCTURAL PROTEINS IN SERA REACTIVE WITH AIDS-ASSOCIATED RETROVIRUS (ARV). Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-6 Kathelyn S Steimer,MA Powers, J Stephans, MA Wormstead, J Levy, P Luciw. Reactivity with p25 and p16 was variable. Certain sera reacted strongly with both proteins, others reacted strongly with only one of the two proteins. We are expanding this study to include a larger panel of sera and a detailed analysis of the response to viral env epitopes. |
| M-7 | ALTERATIONS IN FUNCTIONAL SUBPOPULATIONS OF THE T HELPER AND T SUPPRESSOR CELL POPULATIONS IN AIDS AND CHRONIC, UNEXPLAINED LYMPHADENOPATHY. Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-7 Janet KA Nicholson, JS McDougal, TJ Spira, BM Jones, GD Cross. In both groups of patients, there was a normal representation of la on the T4+ T cells. The increase in TS cells in both patient groups was due to increases in ra+ and Ia- T8 cells and Leu8- T8 cells. |
| M-8 | IMMUNOLOGICAL FEATURES OF SLOWLY PROGRESSIVE NODULAR KAPOSI'S SARCOMA (KS) IN TANZANIA. Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-8 John E Craighead, H Grossmann, W Ershler, A Moore, U Hess, and F Ngowi. KS is common in central and eastern sub-Saharan Africa. Two clinical syndromes occur in adults. Usually it is a slowly progressive process in which nodular lesions develop on the feet and later spread to the legs and upper extremities. The second form occasionally evolves from the first, but it is infiltrative involving the extremities, the head and both the respiratory and digestive tracts. |
| M-9 | APPARENT POLYMORPHISM OF THE T4/LEU3 LYMPHOCYTE SURFACE ANTIGEN IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-9 William G Ramey, GF McKinley, M Lange. The OKT4 epitope has been shown to be closer to the cell membrane than the Leu3a epitope. Since LAV retrovirus-infected T4+ lymphocytes have been shown to lose expression of the OKT4 receptor in vitro, these observations may reflect loss of detectable OKT4 epitopes as a consequence of LAV infection of T cells. |
| M-10 | CORRELATION OF PERIPHERAL BLOOD PHENOTYPES WITH LYMPH NODE BISTOLOGY. Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-10 Paul R Meyer, DC Boone, AM Levine, PS Gill, M Hechinger, JW Parker. Lymphocyte phenotypes on peripheral blood were examined in 42 homosexual males with a diagnosis of persistent generalized lymphadenopathy and were compared with those of 17 asymptomatic male homosexuals. Comparison between blood and lymph node phenotypes were made for 32 of the PGL patients, morphologically classified as follicular. |
| M-11 | A STUDY OF T-CELL SUBSETS IN PATIENTS WITH PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL): COMPARISON OF BLOOD AND TISSUE SECTION RESULTS. Int Conf AIDS. 1985 Apr 14-17;1:31 Abstract No. M-11 Nora CJ Sun, M Gottlieb, JL Fahey, S Knight, G Beall. Reversed T-helper/inducer (T4) and T-cytotoxic/suppressor (T8) ratio is typically seen in patients with acquired immunodeficiency syndrome (AIDS), and is also common in PGL. We measured T4, T8, and pan-T cells by flow cytometry from the blood of 16 homosexual men with PGL, and compared the results from the same patients with those obtained by semi-quantitation on frozen sections using an immunoperoxidase technique. |
| M-12 | PROGNOSTIC IMMUNOLOGICAL VARIABLES IN SYMPTOM FREE (SF) HOMOSEXUALS, AIDS-RELATED COMPLEX (ARC) AND AIDS PATIENTS (PTS). Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-12 Evan M Hersh, J Reuben, P Mansell, A Rios, Y Patt, L Freeman. Other prognostic variables for stage and survival included % T4+ cells, absolute level T4+ cells T4/T8 ratio, LPR to the mitogens, CON-A and PWM, and DTH responses. In evaluation of immunorestoration therapy, T4/8 ratio, LPR and DTH responses were most useful in demonstrating immunorestoration reproduceably. |
| M-13 | ACID-LABILE INTERFERON-ALPHA IN HOMOSEXUAL MEN: A PRECLINICAL MARKER FOR OPPORTUNISTIC INFECTIONS. Int Conf AIDS. 1985 Apr 14-17;1:86 Abstract No. M-13 Craig E Metroka, JA Sonnabend, S Cunningham-Rundles, M Krim. An interferon (IFN) characterized as an acid-labile form of IFN-a has been detected in the sera of patients with AIDS. To determine whether IFN activity in serum may be a marker of early or subclinical disease, we examined its level from serial stored sera from 211 male homosexual patients with opportunistic infections (OI), the prodromal syndrome (Pro), generalized lymphadenopathy (GL), and Kaposi's sarcoma (KS), both with and without systemic symptoms, and campared it to that found in the serum of healthy homosexual controls. |
| M-14 | ALTERED INTESTINAL PLASMA CELLS IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-14 Donald P Kotler, JV Scholes. To examine the secretory immune system in the acquired immunodeficiency syndrome, immunofluorescence studies of plasma cells were performed on small intestinal and colonic biopsies obtained from immunodeficient patients (35 AIDS, 4 ARC), 10 homosexual male controls, and 10 heterosexual controls. |
| M-15 | IDENTIFICATION OF SURFACE ANTIGENS ON IMMUNOGLOBULIN-SECRETING CELLS ISOLATED FROM HOMOSEXUAL MEN WITH GENERALIZED LYMPHADENOPATHY OR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-15 Linda S Martin, JS McDougal, TJ Spira, S Loskoski. One of the abnormalities found in homosexual men with AIDS or lymphadenopathy is the presence of activated B cells that spontaneously secrete immunoglobulin. Even though these abnormal cells may be detected in a reverse plaque assay, they constitute a very small percentage (usually less than 1%) of the total number of lymphocytes, making identification of surface antigens on these cells difficult. |
| M-16 | B CELL ESCAPE FROM IMMUNOREGULATORY CONTROLS IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-16 Susan Zolla-Pazner, W El-Sadr, S Sharpe. Spontaneous synthesis and secretion of IgM by peripheral blood Mononuclear cells were studied with cells from 15 patients with AIDS, 9 patients with AIDS-related complex (ARC) and 24 control subjects after 96 hours of culture in medium without mitogen. |
| M-17 | CELL LINES OF B-CELL LINEAGE ESTABLISHED FROM THE BLOOD OF PATIENTS WITH AIDS AND ARC. Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-17 Fred T Valentine, AM Paolino. The-early detection of monoclonality and the establishment of lines from small numbers of cells suggest an increased frequency in AIDS of cells "immortalized" in vivo by EBV. This may be important in the development of B cell lymphomas. |
| M-18 | MONOCYTE/MACROPHAGE FUNCTION IN AIDS AND PEOPLE AT RISK FROM AIDS. Int Conf AIDS. 1985 Apr 14-17;1:32 Abstract No. M-18 L-J Eales, O Moshtael, AJ Pinching. It has previously been reported that cultured peripheral bleed monocytes from patients with AIDS were able to kill Toxoplasma gondii provided exogenous gamma interferon was added to the cultures |
| M-19 | SUPPRESSION OF PHAGOCYTIC FUNCTIONS BY SEMINAL PLASMA: POSSIBLE PREDISPOSING FACTORS TO AIDS. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-19 Rudolf E Schopf, M Trompeter, P Benes, B Morsches, P Schramm. A pathogenic retrovirus (HTLV-III) has been linked to AIDS. Recently, the virus has also been recovered from seminal fluid of homosexual male patients with AIDS, suggesting that transmission. by seminal fluid is likely. In order to test the possibility that seminal plasma (SP) favors the propagation of infection, we measured the influence of SP on important phagocytic functions. |
| M-20 | IN VITRO LYMPHOCYTE PROLIFERATIVE (LP), NATURAL KILLER CELL (NKC) AND INTERFERON (IFN) RESPONSES (R) TO HERPES (HSV-1, HSV-2) AND CYTOMEGALOVIRUSES (CMV) IN SYMPTOM FREE (SF) HOMOSEXUALS, AIDS-RELATED COMPLEX (ARC) AND AIDS PATIENTS (PTS) AND THE EFFECTS OF IMMUNOMODULATORS ADDED IN VITRO. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-20 Evan M Hersh, J Reuben, P Mansell, A Rios, S Specter, H Friedman. In vitro responses of peripheral blood mononuclear cells (PBMC) to HSV-1, HSV-2 and CMV and their modification by IL-2, IL-l, thymosin F5, α and γ IFN were studied in 25 SF, ARC and AIDS pts and in normal controls (nls) |
| M-21 | MECHANISMS OF DEFECTIVE T COLONY FORMATION IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-21 Alan Winkelstein, TL Evans, RS Klein, LD Weaver. We previously have reported that the T cell colony assay is a sensitive measure of immunologic abnormalities in AIDS. Colony responses were profoundly depressed in 60/62 (97%) of AIDS patients and 21/36 (58%) of those with the ARC. |
| M-22 | IMPAIRED T-LYMPHOCYTE COLONY GROWTH (CFU-T ) AND DETECTION OF A SERUM INHIBITORY FACTOR IN PATIENTS WITH EPIDEMIC KAPOSI'S SARCOMA. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-22 Ronald T Mitsuyasu, T Lee, KJ Lee. These data suggests that impaired CFU-T in AIDS/KS is due to an intrinsic defect in T cell colony progenitors and that patients with AIDS possess a serum inhibitory factor of normal colony growth. |
| M-23 | γ INTERFERON INCREASES THE SUSCEPTIBILITY OF CULTURED HUMAN MACROPHAGES TO MYCOBACTERIUM AVIUM INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-23 Alfred J Crowle, MH May, GS Douvas. Mycobacterium avium (MA) opportunistically causes progressive infection in AIDS, presumably because in AIDS macrophages are not activated to stop its replication. We are using an in vitro model of human MA infection to investigate this problem. |
| M-24 | DEFICIENT CELL-MEDIATED IMMUNITY IN HEALTHY HOMOSEXUAL MEN NEGATIVE FOR ANTIBODY TO HTLV-III VIRUS. Int Conf AIDS. 1985 Apr 14-17;1:33 Abstract No. M-24 Ian R Frazer, IR Mackay, ID Gust, MG Sarngadharan, RC Gallo. We recruited 101 healthy Australian homosexual men in May 1983 for longitudinal study including development of lymphadenopathy syndrome (LAS), AIDS, antibody to HTLV-III virus (HTLV-III ab) by ELISA and Western blotting, and deficient cell-mediated immunity (CMI). |
| M-25 | ANTIBODY TO LYMPHADENOPATHY ASSOCIATED VIRUS CORRELATES WITH DECREASED T HEIPER: T SUPPRESSOR RATIOS IN THOSE AT INCREASED RISK FOR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-25 Barbara Weiser, H Burger, WS Robinson, J Lifson, C. Rouzioux, JC Chermann. T lymphocyte subset analysis showed that the subjects at increased risk for AIDS who were well, LAS patients, and AIDS patients all had significant decreases in mean TH:TS ratios compared with controls (p<0.01 for all comparisons). In subjects at increased risk for AIDS who were clinically well, there was a statistically significant correlation between presence of LAV antibody and inversion of TH:TS ratio due to decreased T helper cells (p=0.007. |
| M-26 | PROLONGED ABNORMALITIES OF T-CELL SUBSETS AFTER CYTOMEGALOVIRUS (CMV) INFECTION IN HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-26 John Mills, WL Drew, J Dylewski, JA Levy, J Preiksaitis, T Merigan. CMV has been suggested as an important co-factor for development of AIDS. We prospectively studied CMV-susceptible homosexual men to determine the immunologic and clinical effects of infection. Among 35 seronegatives, 12 became infected. The median duration of follow-up prior to infection was 6.5 months. |
| M-27 | SCALING THE SEVERITY OF HTLV-III/LAV RELATED , IMMUNOLOGIC ABNORMALITIES. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-27 Don C Des Jarlais, SR Friedmann, M Marmor, TJ Spira, S Zolla-Pazner, U Mathur. The imminent application of large scale HTLV-III/LAV antibody testing emphasizes the need for methods of interpreting results. In this paper we present two methods for comparing severity of HTLV-III/LAV-related immunologic abnormalities across individuals and across time for the same individual. |
| M-28 | IMMATURITY, ACTIVATION AND INCOMPETENCE IN T AND B CELLS FOLLOWING HTLV-III INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-28 JL Fahey, K Schwartz, J Salazar, P Nishanian, G Beall and J Taylor. Activation of B cells was found in many HMH subjects. The role of HTLV-III as a direct and indirect cause of the diverse immune alterations is underway. Some but not all of these changes are seen in HMH who have evidence of other infection but are seronegative for HTLV-III. |
| M-29 | NATURAL CELL MEDIATED CYTOTOXICITY (NCC) TO CELL LINE K562 PER LEU 11 PESITIVE CELL (NK) IS DECREASED IN ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-29 Georgeann Baron, NG Klimas, M Fischl, MA Fletcher. Our data show that the proportion of NK cells to other mononuclear cells is unchanged in the AIDS patient. However, the NK cells in the AIDS patient are in a less active state compared to normals. |
| M-30 | SELECTIVE IMPAIRMENT OF MONOCYTE CHEMOTAXIS IN DRUG ADDICTS WITH LYMPHADENOPATHY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:34 Abstract No. M-30 Guido Poli, Barbara Bottazzi, Flavia Zanaboni, Adriane Lazzarin, Mauro Moroni, A, Mantovani. LAS occurred in 15 IV drug addicts in a suburb of Milan. Ten of 15 had profound impairment of NK cell activity. In vitro exposure to interferon (recombinant, Genentech; natural, Sclavo) augmented NK activity of LAS lymphoid cells. |
| M-31 | ANTI-LYMPHOCYTE ANTIBODIES IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-31 William Cronin, B Dorsett, HL Ioachim, V Chuma. The characteristic findings of lymphopenia and inverse helper/suppressor lymphocyte ratios in patients with AIDS raise questions as to the mechanism by which such specific cell depletion occurs. To investigate the possible presence of antilymphocyte antibodies, we incubated lymphocytes of normal donors with sera of AIDS patients. |
| M-32 | NEOANTIGEN EXPRESSION ON LYMPHOCYTES OF PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND GROUPS AT RISK. Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-32 John T Carey, MM Lederman, BZ Schacter, and JJ Ellner. The monoclonal antibody (MoAb) 4D12 recognizes a Class I major histocompaibility-like antigen newly expressed on the surface of human lymphocytes infected in vitro by the retrovirus HTLV-l. |
| M-33 | NEUTROPHIL-ASSOCIATED ANTIBODIES AND GRANULOCYTOPENIA IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-33 Eric Outwater and JA McCutchan. The incidence and mechanism of neutropenia in AIDS has not been well documented, but has been of clinical importance in a number of our patients because it limited therapy for Kaposi's sarcoma. |
| M-34 | CORRELATION OF ANTILYMPHOCYTE ANTIBODIES (ALA) WITH SEROPOSITIVITY FOR LYMPHADENOPATHY VIRUS (LAV). Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-34 Dobri D Kiprov, P Morand, A Moss, JC Sherman, T Spira. An indirect immunofluorescence assay for antibodies to normal human lymphocytes was performed simultaneously with a test for antibodies to LAV on l2S serum samples. Each test was performed without prior knowledge of the results of the other test. |
| M-35 | DEFICIENCY OF ERYTHROCYTE RECEPTORS FOR C3B IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-35 Francisco Tausk, JA Mccutchan, P Spechko, R Schreiber, I Gigli. The level of RBC-CRI decreased significantly in groups increasingly at risk of AIDS. Studies of families of 5 AIDS patients suggest that this defect is acquired. Depletion of erythrocyte CR1 may occur early in HTLV III/LAV infection, could help to explain such manifestations as immune cytopenias and glomerulitis, and suggests that transfusion of normal erythrocytes could ameliorate CIC-mediated processes. |
| M-36 | IMMUNOLOGICAL ALTERATIONS IN SAIDS. Int Conf AIDS. 1985 Apr 14-17;1:35 Abstract No. M-36 Delia B Budzko, WT London, DL Madden, M Gravell, R Henrickson, JL Sever. These results indicated that in vitro evidence of immunosuppression due to SAIDS appears within a few weeks after infection and this progresses in animals that die and returns to normal in animals that survived. |
| M-37 | EPIDEMIOLOGICAL SITUATION OF AIDS IN THE FEDERAL REPUBLIC OF GERMANY. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-37 Johanna L'age-Stehr. Since early 19B2 AIDSis diagnosed in residents of the FRG and West-Berlin. AIDS is not a notifiable disease in the FRG, all informations are submitted voluntarily by physicans to the AIDS working group of the Federal Health Office |
| M-38 | EPIDEMIOLOGY OF HTLV III INFECTIONS IN PANAMANIAN HIGH RISK POPULATIONS. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-38 Stephen Wignall, W Reeves, R de Britton, J Clark, C Saxinger, Z Salahoudin. Sixty-six homosexual Panamanian males have been evaluated along with two documented AIDS cases in a lab supported descriptive epidemiologic investigation of HTLV III infections. Participants are interviewed to determine demographic, sexual, drug use and other potential clinical risk factors; are examined; blood collected for HTLV III isolation, CBC, hepatitis screening; cultures done for common STD agents and stools collected for O&P exam. |
| M-39 | SPREAD OF HTLV-III IN ITALY. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-39 F Aiuti, MC Sirianni, P Rossi, M Moroni, L Contu, RC Gallo. The spread of HTLV-III infection in Italy was investigated by analyzing the presence of antibodies to the virus in the sera of patients with AIDS and lymphadenopathy syndrome (LAS) in individuals at risk for AIDS and in normal controls. The epidemiological survey was carried out in several Italian cities. Positivity was 90% in AIDS. |
| M-40 | AIDS IN AUSTRALIA. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-40 J Gold, S McGinness, P Vodicka. Since the first case of AIDS was confirmed in Australia, in December 1982 there has been a steady increase in the incidence rate that parallels the United States experience. AIDS, as defined by CDC is a notifiable disease in all states and territories and each suspected case is confirmed by the Australian AIDS Task Force. |
| M-41 | CURRENT TRENDS IN AIDS IN THE UNITED STATES. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-41 WM Morgan, RH Selilk, AM Hardy, ET Starcher, JR Allen. As of November 26, 1984, 6,921 adult and 72 pediatric cases of AIDS had been reported to CDC. Adjustments for delays in reporting indicate that approximately 8,100 cases had actually been diagnosed in the United States by that date. Seventy-three percent of the reported adult cases occurred in homosexual/bisexual men, 184 in IV drug abusers, 44 in Haitian entrants, 14 in hemophiliacs, 1% in heterosexual contacts of persons with AIDS or in one of the risk groups, 1% in persons who received transfusions of blood or blood components, and 4% in persons who could not be placed into any of these risk groups. |
| M-42 | SEARCH OF AIDS CASES IN SECONDARY IMMUNODEFICIENCY PATIENTS IN THE USSR. Int Conf AIDS. 1985 Apr 14-17;1:36 Abstract No. M-42 Rakhim M Khaitov. To examine the previously healthy individuals with chronic lesions of immune system for revealing possible Acquired Immunodeficiency Syndrome (AIDS) cases, 500 patients suffering lymphoproliferative diseases and lymphoadenopathy of obscure etiology, unreadily curable secondary immunodeficiencies associated with hemophilia and pneumonia of unclear origin, inexplicable weight loss and fever, persisting cytomegalovirus infection were studied. |
| M-43 | AIDS SURVEILLANCE IN A CENTRAL AFRICAN CITY: KINSHASA, ZAIRE. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-43 Jonathan M Mann, R Rutl, H Francis, B Kapita, T Quinn, JW Curran. In July 1984, the Project SIDA, a collaborative international project studying AIDS In Zaire. Initiated city-wide hospital-based surveillance for AIDS In Kinshasa. The case definition based on earlier published experience in Zaire, included strict clinical and laboratory criteria. |
| M-44 | AIDS: NATIONWIDE EPIDEMIOLOGICAL SURVEILLANCE IN ITALY. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-44 G Ippolito, G Rezza, F DI Raimondo, D Greco, A Zampieri. In Italy the group for the National Surveillance of AIDS has been set up in March 1983 to institute a register of cases, describe the trend and identify risk factors related to the syndrome. Sixteen cases (14 males and 2 females), according to the CDC criteria, have been reported until November 1984; the first 2 Italian cases, diagnosed in USA in 1981, were directly reported to the CDC. |
| M-45 | THE AIDS EPIDEMIC IN NEW YORK CITY: SURVEILLANCE TRENDS. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-45 Pauline A Thomas. Since the epidemic of the acquired immunodeficiency syndrome (AIDS) was first recognized in 1981, New York City (NYC) has had more total cases and a higher incidence than any other city in the world. As of November 19, 1984, 2686 cases had been reported to the NYC DOH, a cumulative incidence of 38 cases per 100,000. |
| M-46 | EPIDEMIOLOGICAL ASPECTS OF AIDS CASES FROM PUERTO RICO. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-46 HF Gorbea, Y Kouri, CH Ramirez-Ronda, JR Rodriguez, EH Frankhanel, J Garib. From 1981 until October 1, 1984 there have been 86 cases of AIDS diagnosed in Puerto Rico that meet the CDC criteria for the diagnosis. Of the 86 cases, 15 developed the symptomatology outside P. R., mostly NYC, the other 71 are local cases. In 1981 the diagnosis was made in one case, followed by 9 in 1982, 30 in 1983 and 46 in the first 9 months of 1984. There are 78 (91%) males and 8 (9%) females. |
| M-47 | MODELING ACQUIRED IMMUNODEFICIENCY SYNDROME IN NEW YORK, SAN FRANCISCO AND LOS ANGELES. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-47 John Pickering, JA Wiley, N Padian, D Lyman, DF Echenberg, L Lieb. By Nov. 1984, reported AIDS cases in N.Y. ,S. F. and L.A. totaled 2287, 761 and 574, respectively. Although the accumulative number of cases diagnosed per month doubled in these cities in the 9 - 11 months before Aug. 1984, the incidence of AIDS will not necessarily continue to increase. A discrete, non-linear model is used to explore underlying biological characteristics of the AIDS epidemics and forecast new cases. |
| M-48 | THE UTILIZATION OF MARKETING PRINCIPLES FOR RECRUITMENT OF GAY MEN FOR AIDS RESEARCH. Int Conf AIDS. 1985 Apr 14-17;1:37 Abstract No. M-48 Anthony Silvestre, LA Kingsley, CR Rinaldo, DW Yyter, R Forrester and J Huggins. Since April, 1984, 1150 gay men have been enrolled in the Pitt Men's Study, one of five centers in the NIH Multicenter AIDS Cohort Study (MACS), a prospective study of the natural history of AIDS. Recruitment of this cohort from a relatively small gay community has required the development of specialized outreach techniques. Research of the characteristics of our gay male community and other communities was conducted. |
| M-49 | DISCRIMINANT FUNCTION ANALYSIS OF SYDNEY AIDS DATA DISCRIMINANT FUNCTION ANALYSIS OF SOCIAL, MEDICAL, CLINICAL, AND PATHOLOGY DATA FROM 700 SYDNEY HOMOSEXUALS. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-49 JL Burcham, J Gold, D Cooper, R Penny. Discriminant Function Analysis identifies each group by its discriminating variables: lifestyle factors, symptoms, and sexual, medical, and clinical history. New cases can be classified into selected groups. This classification contributes to the prognosis for the individual patient and the collected data base is a predictive model for the community. |
| M-50 | THE RELIABILITY OF SEXUAL HISTORIES IN AIDS-RELATED RESEARCH: EVALUATION OF AN INTERVIEW-ADMINISTERED QUESTIONNAIRE. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-50 Randall A Coates, CL Soskolne, L Calzavara, SE Read, MM Fanning, FA Shepherd. Prior to recruitment for a prospective study of male sexual contacts of men with AIDS or ARC, a detailed interview-administered questionnaire was tested for reliability. Twenty-six homosexual men volunteered to undergo the same interview 48 hours apart and administered by two different interviewers. On average, interviews lasted 60 minutes. |
| M-51 | TUBERCULOSIS AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN NON-HAITIAN INTRAVENOUS DRUG ABUSERS. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-51 Frederick P Duncanson, D Hewlett, S Maayan, H Estapan, EN Perla, GP Wormser. No patient died of TB, IVDA with TB and AIDS or ARC had more extrapulmonary TB, negative PPD*, lymphopenia, slow responses to therapy, adverse reactions, and reversed T-cell ratios* compared with TB controls (*significant at p<0.05) |
| M-52 | MYCOBACTERIUM AVIUM COMPLEX (MAC) BACTEREMIA IN AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-52 Timothy Kiehn, P Brannon, C Hawkins, J Gold, R Cammarata, D Armstrong. Since 1981 we have used a variety of blood culture systems to detect MAC bacteremia in 36 AIDS patients. During 1984 the Isolator system was used for all blood cultures, and for MAC detection, 1.5 ml of sediment was inoculated onto 4 Middlebrook 7Hll agar plates. In an attempt to decrease detection time, 0.2 ml of Isolator sediment from some cultures was also inoculated into Bactec 12A broth medium. |
| M-53 | MYCOBACTERIUM TUBERCULOSIS (MTB) INFECTION IN PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-53 Eddie Louie, LB Rice, RS Holzman. From 1-1-81 to 10-31-84, 66 of 280 patients with AIDS, seen at Bellevue Hospital, had culture proven mycobacterial infection. We are reporting data from all 24 cases of infection with Mtb. AIDS risk factors included homosexuality (11), drug abuse (10), both (1), promiscuity (1) and sexual contact with bisexuals (1). |
| M-54 | GROWTH AND PERSISTANCE OF M. AVIUM-INTRACELLULARE IN THE NORMAL VS. THE IMMUNOSUPPRESSED HOST. Int Conf AIDS. 1985 Apr 14-17;1:38 Abstract No. M-54 Frank M Collins, Richard W Stokes, Vincent Montalbine. M. avium-intracellulare strains vary extensively in their ability to multiply and survive within the lungs and spleens of normal C57B1×DBA F1 hybrid mice depending upon the dose and route of inoculation. |
| M-55 | CORONAVIRUS-LIKE PARTICLES IN PATIENTS WITH AIDS & ARC. Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-55 Peter Kern, H Schmitz, G Müller, S Essuman, M Dietrich. In addition, we found such particles in the serum of 1 patient with ARC and diarrhea which suggests invasion and systemic spread of the virus. Thus, CVLP might be considered as another opportunistic agent in groups at high risk for AIDS. |
| M-56 | IMMUNOLOGIC DEFICIENCY IN CASTLEMAN'S SYNDROME (CS) ASSOCIATED WITH HTLV-3 VIRUS. Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-56 Robert Miles-Lawrence, T Leimert, N Olson, N Tirumali, K Chang. These findings suggest that systemic CS may be a hither to unrecognized immune deficiency disease with features similar to but not the same as AIDS. However, the similarity in morphologic and immunologic findings in CS and AIDS raise the question of HTLV-3 being a common etiologic factor for a spectrum of immune deficiency disorders. |
| M-57 | LYMPH NODE IMMUNOPATHOLOGY OF HOMOSEXUALS WITH LYMPHADENOPATHY OR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-57 Peter,Biberfeld, A Porwit, B Bottiger, L Morfelt, G Biberfeld. Lymph nodes of 45 cases with persistent, generalized lymphadenopathy (PGL) and 10 with AIDS, without Kaposi were analyzed in search for prognostic factors. All AIDS cases showed uniform histopathology characterized by the complete depletion of follicular areas, predominance of lymphocytes with T8 phenotype and in most cases prominent angiogenesis. |
| M-58 | MORPHOLOGICAL MARKERS IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-58 Herbert E. Nieburgs. In a study of lymphocytes in peripheral blood smears from patients with known acquired immune deficiency syndrome, particular nuclear alterations were noted and differed from normal controls and from those with a variety of other diseases. |
| M-59 | LYMPHOID INTERSTITIAL PNEUMONIA IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-59 Mario J Saldana, JM Mones, GB Scott and MA Fischl. Lymphoid intersitial pneumonia (LIP) is an uncommon pulmonary disorder characterized by diffuse, bilateral infiltrates largely composed of lymphocytes and plasma cells. Dysgammaglobulinemia is frequently seen and its association with Sjogren's syndrome is well recognized. The natural progression of LIP is toward diffuse interstitial fibrosis of the lungs but some cases may evolve toward lymphoma. |
| M-60 | LYMPHOID INTERSTITIAL PNEUMONITIS (LIP) IN HAITIANS AND AFRICANS: AN AIDS-LINKED ENTITY? Int Conf AIDS. 1985 Apr 14-17;1:39 Abstract No. M-60 LJ Couderc, S Matheron, PH Solal-Celigny, I Caubarrere, AG Saimot, Jean-Pierre Clauvel. Seven patients (5 male, 2 female; age 24-53 years; 6 without known risk factor for AIDS) originated from Haiti (4 cases) and Central Africa (3 cases) were investigated for LIP. In the 3 first patients, lung biopsy showed lymphocytic infiltration of alveolar septa and lymphatic vessels. |
| M-61 | GRANULOMATOUS HEPATITIS IN AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-61 Sarah Kahn, B Saltzman, LJ Brandt, RS Klein, P Mahadevia, J Frager. Hepatic granulomas are a frequent finding in AIDS pts and usually represent disseminated mycobacterial infection. Despite therapy, prognosis is poor. |
| M-62 | THE EVALUATION OF UNEXPLAINED GENERALIZED LYMPHADENOPATHY IN THE AIDS-RELATED COMPLEX. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-62 Renslow Sherer, and Ron Sable. To further define "unexplained" generalized lymphadenopathy (gen LN) in the AIDS-related complex (ARC), we employed a sequential protocol in 35 ARC patients for the evaluation of gen LN, which included a history and physical, chest xray, RPR, PPD, anergy testing, CBC, ESR, HbsAg/Ab, viral titers, immune globulins, serum A.C.E., gallium scan, and lymph node biopsy and culture. |
| M-63 | AIDS ENTERITIS: A HISTOLOGICAL AND IMMUNOHISTOLOGICAL CHARACTERIZATION OF GASTROINTESTINAL BIOPSIES IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-63 T Scott Croxon, AB Chabon, WE Chapman. Chronic diarrhea is a common problem of AIDS and pre-AIDS patients. Gastrointestinal biopsies (GI bx] are often obtained to exclude specific pathogens. We studied 40 GI bx from 25 AIDS patients and compared the histologic and immunohistologic features to Crohn's disease (CD] and ulcerative colitis [UC]. |
| M-64 | PULMONARY KAPOSI'S SARCOMA IN THE ACQUIRED IMMUNODFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-64 Stuart M Garay, M Belenko, E Fazzini, R Schinella. Approximately 50% of patients with AIDS have KS. However, pulmonary involvement with this tumor is rare and usually undiscovered prior to autopsy. During the past 4 years 325 patients with KS associated with AIDS have been diagnosed at this medical center; 19 had documented pulmonary involvement. All patients were male homosexuals (mean age=38; range 29-50). |
| M-65 | CLINICO-PATHO-THERAPEUTIC STUDIES OF UNUSUAL CASES OF KAPOSI'S SARCOMA WITH A POSSIBILITY OF THE OCCURRENCE OF ACQUIRED IMMUNODEFICIENCY IN ONE FEMALE PATIENT. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-65 Aly Ibrahim, MD. Three cases of Kaposi's sarcoma presented in this study showed peculiar features. The first case was in a 37 year old woman who indulged in extramarital normal and abnormal sexual relations, i.e., sodomy. She presented general constitutional manifestations in the form of fever, headache, arthralgia, pallor, feeling ill-health, and general fatigue with classic disseminated cutaneous lesions, thrombocytopenic purpura, hepatosplenomegaly, and ascites. |
| M-66 | HUMAN LYMPHOBLASTOID INTERFERON TREATMENT OF KAPOSI'S SARCOMA IN ASSOCIATION WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:40 Abstract No. M-66 Margaret A Fischl, E Gollowski, G Koch, G Wang, M Fletcher, S Lucas. We evaluated lymphoblastoid interferon (Wellferon) alone and in combination with Vinblastine in KS associated with AIDS. Patients with skin disease, lymph node disease, and/or minimal oral lesions were treated with Wellferon alone. All others received combination therapy. |
| M-67 | IMMUNE STATUS OF PATIENTS WITH KAPOSI'S SARCOMA FROM VARIOUS POPULATION GROUPS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-67 R Sher, JI Phillips, S Antunes, J Scrowston. Of 10 cases which were tested for antibodies to HTLV-lll, 4 were positive - one heterosexual caucasian, one AIDS Kaposi's and 2 black heterosexuals. This limited study reveals that Kaposi's sarcoma in heterosexual caucasions and in 62.5% of heterosexual blacks, is not associated with defective CMI. |
| M-68 | TREATMENT OF AIDS WITH HYPERIMMUNE SERUM TO LYMPHADENOPATHY VIRUS (LAV). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-68 Arye Rubinstein, B Krieger, M Sicklick, L Bernstein, B Novick, A Wiznia. Six adults with end stage AIDS and opportunistic infections with/without Kaposi's sarcoma were studied. The disease course of all patients was relentlessly progressive with septic temperatures, wasting, leukopenia, lymphopenia, and markedly impaired T and B cell functions. |
| M-69 | THERAPEUTIC APHERESIS IN HOMOSEXUAL MEN WITH INFLAMMATORY POLYNEUROPATHY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-69 Dobrid Kiprov, R Lippert, I Lipkin, D Abrams, RG Miller. A peripheral neuropathy syndrome occurs in some patients with AIDS or the lymphadenopathy syndrome. The presence of circulating antimyelin antibodies and their deposition along Myelin sheaths in sural nerve biopsies suggest an immune mediated mechanism. |
| M-70 | PILOT STUDY TO EVALUATE THE IN VIVO EFFECTS OF THYMOSIN FRACTION 5 (TF5) IN MALE HOMOSEXUALS (HO) AND HEMOPHILIACS (HE) WITH IMPAIRED CELLULAR IMMUNITY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-70 Richard S Schulof, G Simon, M Sztein, J Orenstein, R Gallo, A Goldstein. TF5 improved the immune functions of many Ho/ He but did not generally normalize the baseline T4/T8 ratio, or other surrogate markers for AIDS if they were present prior to therapy including elevations of serum alpha interferon or 82 microglobulin levels; nor did it influence the presence of AIDS-associated ultrastructural markers if they were detected in PBL prior to treatment. |
| M-71 | THYMUS TRANSPLANTATION IN AIDS AND RECURRENCE OF HTLV-III INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-71 JM Dupuy, DO Pekovic, H Goldman, C Tsoukas, N Gilmore, Y Thibodeau, L Pelletier, M Joly, R Duperval. Since October 1963, 14 adult patients with AIDS have received one or several thymic grafts. All cases had opportunistic infections and 3 patients also had Kaposi's sarcoma. Thymic tissue from infants undergoing cardiac surgery was cultured for 3 weeks to provide epithelial cells free of lymphocytes and fibroblasts. |
| M-72 | PHASE-I/II TRIAL OF RIL-2 IN PATIENTS WITH AIDS & ARC. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-72 Peter Kern, J Toy, W Meigel, M Dietrich. Toxicity and clinical response of recombinant Interlcukin-2 (rIL-2) were studied in 6 patients with AIDS and in 6 patients with ARC. |
| M-73 | THE USE OF ISOPRINOSINE IN AN ATTEMPT TO IMPROVE IMMUNE FUNCTION IN AIDS AND AIDS RELATED COMPLEX. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-73 Peter WA Mansell, J Reuben, M Odem, A Rios, E Hersh. Similar nonsignificant changes were seen in the other immunological, hematological and biochemical parameters. Nine of the AIDS patients died. Of the remainder, 10 patients experienced subjective or objective improvement in symptoms. No toxicity attributable to the drug was seen. Isoprinosine, used as a single agent in this schedule, is not an effective means of reversing immune abnormalities in patients with ARC. We suggest further trials of Isoprinosine in patients with early ARC and no prior infection. |
| M-74 | AMELIORATION OF SYMPTOMATOLOGY AND PARTIAL IN VIVO IMMUNORESTORATION WITH AZIMEXON (AZ) IN AIDS RELATED COMPLEX (ARC). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-74 Yehuda Z. Patt, P Mansell, J Reuben, A Mazumder, S Li, E Hersh. No symptomatic or immunologic improvements were observed among 12 AIDS patients. Preincubation of normal lymphocytes with AZ and then with PHA and assaying supernatants for IL-2 suggested that immune augmentation was associated with increased IL-2 production. Cyan aziridinyl immune modulators should be studied further in ARC/AIDS. |
| M-75 | IMMUNOMODULATION BY CIAHEXONE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-75 J. Mertin, U. Bicker, W. Pahlke. Delayed-type hypersensitivity reactions following sensitisation and subsequent challenge of mice with oxazolone, or sheep red blood cells, are augmented. Cellularity of the bone marrow and in the peritoneal cavity was found to be increased after CIM treatment of normal or Cy-treated mice; local GvH reactions were suppressed. We feel that CIM may be a good candidate for the treatment of patients with ARC or AIDS. |
| M-76 | ORAL VIRAL LEUKOPLAKIA IN ASSOCIATION WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-76 D Greenspan, JS Greenspan, LS Kaminsky, JA Levy, S Silverman, Jr. and Y de Souza. The lesion may be predictive of AIDS and raises important questions concerning the role of local immune mechanisms in preventing mucosal colooization by viruses and regarding the etiology of oral epithelial hyperplasia, dysplasia and neoplasia. |
| M-77 | URINARY AND RENAL HISTOLOGICAL CHANGES IN CHILDREN WITH ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-77 B Montane, Gwendolyn Scott, G Zilleruelo, M Freundlich, C Abitbol, J Strauss. We conclude that AIDS Is often associated with urinary changes, often grossly abnormal; associated renal histological changes appear to he mild or absent. These changes are not as severe as those in adults possibly due to the shorter duration of the disease, lack of associated complicating factors (drug addiction. etc.) or the renal and immune characteristics of children; stili they may carry prognostic significance. |
| M-78 | GLOMERULAR LESIONS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS): CLINICOPATHOLOGIC CORRELATIONS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-78 Victoriano Pardo, D Jaffe, M Aldana, M Fischl, G Hensley and J Bourgognie. Moderate asymptomatic proteinuria was equally present in patients with and without Glomerular mesangial changes and overt proteinuria was seen only in the presence of FSS. Intercurrent and terminal episodes of acute renal failure were frequent. However, end stage renal disease developed only in 3 FSS cases who required chronic hemodialysis. |
| M-79 | CENTRAL NERVOUS SYSTEM (CNS) TOXOPLASMOSIS COMPLICATING AIDS: ANALYSIS OF 20 PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-79 BA Navia, CK Petito, J Gold, BD Jordan, E-S Cho, Richard W Price. Between January 1980 and June 1984, we have identified 20 patients with CNS toxoplasmosis complicating AIDS. In 16 of these, toxoplasmosis was suspected clinically, while in 4 diagnosis was made only at autopsy although clinical manifestations had been present during life. |
| M-80 | CEREBRAL TOXOPLASMOSIS (CNS-T) IN AIDS PATIENTS (A): CLINICAL PRESENTATION WITH LABORATORY, RADIOGRAPHIC AND HISTOLOGIC CORRELATIONS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-80 Gifford S Leoung, J Mills, WK Hadley, J Remington, C Wofsy. CNS-T must be considered In all AIDS-risk A with either diffuse encephalopathic or focal findings; diagnosis cannot be excluded even In A lacking IgG and IgM Ab; brain biopsy remains the best means of diagnosis. |
| M-81 | NEUROLOGIC MANIFESTATIONS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-81 Robert Levy, MD, PhD, Dale Bredesen, MD, Mark Rosenblum, MD. The protean behavior of AIDS and the problems associated with the clinical, radiologic and serologic diagnosis of the unusual and varied associated nervous system diseases suggest that biopsies of CNS lesions be performed for diagnosis before therapy is begun. |
| M-82 | HERPES VIRUS NEUROLOGICAL DISEASES ASSOCIATED WITH AIDS: RECOVERY OF VIRUSES FROM CENTRAL NERVOUS SYSTEM (CNS) TISSUES, PERIPHERAL NERVE, AND CEREBROSPINAL FLUID (CSF). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-82 Richard D Dix, Dale E Bredesen, Richard L. Davis, and John Mills. Our findinqs broaden the spectrum of neurological illnesses which may complicate AIDS and emphasize the importance of culturing CNS tissues, peripheral nerve, and CSF obtained from this patient population for viruses. |
| M-83 | PROTEIN CALORIE MALNUTRITION AS A PRESENTING MANIFESTATION OF HUMAN RETROVIRUS (HTLV III) INFECTION IN INFANTS AND CHILDREN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-83 Gwendolyn B Scott, W Parks and M Jonas. Five children with protein calorie malnutrition and positive antibody titers to human retrovirus (HTLV III) were identified at Jackson Memorial Hospital in Miami, Fl. between May, 1983 and September, 1984. All children were of Haitian parentage and were born in Miami. There were two males and three females. Age at presentation ranged between nine and thirty-one months. |
| M-84 | ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) IN INFANTS AND CHILDREN: REPORT OF NINE CASES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. M-84 Fred Rosner, M Frogel, M Charytan, A Rubinstein. We conclude that although many of the clinical and laboratory features of pediatric and adult AIDS are similar, there are significant differences. In infants and children with AIDS, opportunistic infections may be absent and lymphopenia is not universal whereas parotitis, low birth weight, failure to thrive, oropharyngeal thrush and recurrent bacterial and viral infections are common. |
| S10A | SPECTRUM OF HTLV III INFECTION IN CHILDREN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S10A Savita Pahwa, M Kaplan, S Fikrig, M Popovic, A Sarngadharan, R Pahwa. Clinical and laboratory findings were evaluated in 18 children, aged 6 mo to 11 years who were positive for serum antibody to the p41 antigen of the HTLV III virus by Westernblot analysis. 16 patients (pt) were in risk groups for AIDS. |
| S10B | CLINICAL FINDINGS IN PEDIATRIC ACQUIRED IMMUNE DEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S10B Anthony Minnefor, J Oleske, M Zabala, R Bobila, L Epstein, M Boland. There appeared to be two patterns of disease presentation: early age of onset, opportunistic infection and high mortality vs later age of onset, non infectious interstitial pneumonia and chronic symptoms with a lower mortality rate. The later group may have a lessening of mortality and morbidity if aggressive supportive care is provided. |
| S10C | THE CLINICAL SPECTRUM OF HTLV-III DISEASE AT WALTER REED ARMY MEDICAL CENTER. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S10C Robert R Redfield, SZ Salahuddin, PD Markham, MG Sarngdaharan, DC Wright, TM Folks. The clinical charecteristics and course of patients, with HTLV-III disease (AIDS Related Complex and AIDS) will be described. More than 30% of cases identified lack defined risk factors. Clinical features include generalized extra-inguinal lymphadenopathy, skin lesions, defects in delayed hypersensitivity, and oral candidiasis, associated with a persistent depletion of T helper cells and HTLV-III viremia. |
| S10D | THE SPECTRUM OF CLINICAL AND IMMUNOLOGIC RESPONSE TO ARV INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S10D David A. Cooper, J Gold, W May, R Penny, LS Kaminsky, JA Levy. A prospective study to evaluate epidemiologic, clinical, immunologic and serologic factors for the development of AIDS in homosexual men in Sydney was commenced in February 1984. Clinical categorization was determined according to the NHMRC (Australia) criteria. T cell subsets and antibodies to the AIDS-associated retrovirus (ARV) were determined by indirect immunofluorescence. |
| S11A | RISK FOR HTLV-III EXPOSURE AND AIDS AMONG PARENTERAL DRUG ABUSERS IN NEW JERSEY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S11A Stanley H Weiss, HM Ginzburg, JJ Goedert, RJ Biggar, BA Mohica, WA Blattner. These data help to account for the tight geographic distribution of AIDS in parenteral drug users and strengthen the evidence that HTLV-III is the primary etiologic agent of AIDS. |
| S11B | BEHAVIORAL RISK FACTORS FOR HTLV-III/LAV SEROPOSITIVITY AMONG INTRAVENOUS DRUG ABUSERS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S11B Henry Cohen, M Marmor, D Desjarlais, T Spira, S Friedman, S Yancovitz. Antibodies to HTLV-III/LAV were measured in 274 intravenous drug abusers attending methadone maintenance or detoxification programs in New York City. Seroprevalence was 68% (46/68) in females and 56% (116/205)in males. Logistic regression identified significant relative risks for HTLV-III/LAV-exposure in females associated with the frequency of drug injection in the period 2-5 years prior to interview when using personally owned equipment. |
| S11C | PROSPECTIVE EVALUATION OF HEALTH-CARE WORKERS WITH PARENTERAL OR MUCOUS-MEMBRANE EXPOSURE TO BLOOD FROM PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME, UNITED STATES: AN UPDATE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S11C Eugene McCray, N Winslow,SL Solomon, WJ Martone, IM Onorato, VP Munn. In Aug. 1983, CDC initiated a nationwide prospective surveillance of health-careworkers (HCWs) with documented parenteral or mucous membrane exposure to blood or body fluids of patients with definite or suspected acquired immunodeficiency syndrome (AIDS). The aim of the surveillance system is to evaluate risk to HCWs of acquiring AIDS by such exposures. Each HCW registered is followed for 3 years with semiannual interviews and blood specimen collection. |
| S11D | RISK FOCTORS FOR AIDS AMONG HAITIANS IN THE UNITED STATES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S11D Kenneth G. Castro, MA Fischl, SH Landesman, JM Johnson, JC Compas, JC Desgrange. Data analysis completed thus for suggests that, among this study population, sexual activities related to gonorrhea transmission and sexual contact with prostitutes ore significant risk factors associated with AIDS. |
| S12A | SELECTIVE DEPLETION OF LEU3+ LEU8+ MONONUCLEAR CELLS IN AIDS RELATED COMPLEX (ARC) HTLV-III VIREMIC PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S12A Robert R Redfield, TM Chused, PD Markham, SZ Salahuddin, TM Folks, MG Sarngadharan. Using directly labeled monoclonal antibodies and multiparameter flow cytometry, we demonstrated the major mononuclear leukocyte classes and their subsets in 8 ARC patients. All patients had HTLV-III infection documented by both virus isolation and serum antibody to viral structural proteins; however, they lacked evidence of ongoing HBV, EBV or CMV replication. |
| S12B | DISEASE-SPECIFIC AUTOANTIBODIES TO T CELLS IN PEDIATRIC AND ADULT ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S12B Catherine B Small, L Bernstein, A Rubinstein. AIDS is characterized by a quantitative and qualitative defect in the helper T cell subset (T4). In this study, we isolated a T cell-reactive IgG autoantibody from the sera of an adult homosexual and a child with AIDS which selectively reacts with over 50% of AIDS and AIDS-related complex T cells, but not with T cells obtained from normal controls or patients with immunodeficiencies other than AIDS. |
| S12C | PROGNOSTIC IMMUNOLOGIC VARIABLES IN EPIDEMIC KAPOSI'S SARCOMA (KS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S12C Ronald T. Mitsuyasu, R Afrasiabi, J Taylor, M Weaver, JL Fahey. Impaired immune functioning underlies the development of AIDS associated Kaposi's Sarcoma and may account for its aggressive clinical behavior. We studied 15 immune parameters with respect to survival and the occurrence of opportunistic infections (OI) in 95 patients with epidemic KS seen over a 16 mos period at UCLA. |
| S12D | ABNORMALITIES IN MUCOSAL LYMPHOCYTE POPULATIONS IN PATIENTS WITH AIDS AND THE LYMPHADENOPATHY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S12D VD Rodgers and Martin F. Kagnoff. Persistent infestation with the protozoal parasite Cryptosporidia is an important cause of diarrhea in AIDS. We have studied the phenotypic distribution of small intestinal lymphocyte populations among healthy homosexual males, homosexual males with Lymphadenopathy Syndrome and homosexual males with AIDS. |
| S12E | CYTOTOXIC CAPABILITIES OF LYMPHOCYTES FROM AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S12E Jan Gerstoft, E Dickmeiss, L Mathiesen. Cytotoxic T-lymphocytes (CTL) are crucial in other host response towards a number of infections contracted by AIDS patients. As antigen specific self MHC restricted CTL can be derived from within the alloreactive CTL we studied lymphocytes from 16 AIDS patients in the cell-mediated lympholysis assay (CML). |
| S13A | TRANSFUSION-ASSOCIATED AIDS IN THE UNITED STATES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S13A TA Peterman, HW Jaffe, PH Feorino, DT Warfield, JP Getchell, DP Francis, JW Curran. Ninty-two cases of possible transfusion-associated AIDS have been reported to the Centers for Disease Control as of December 3, 1984. The number of cases is increasing rapidly, with 33 (16%) diagnosed in the first half of 1984. Although cases have received transfusions in 25 states, 37 (40%) received transfusions in either New York or California. |
| S13B | RISK OF AIDS FROM BLOOD DONORS WHO SUBSEQUENTLY DEVELOP AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S13B Herbert A Perkins, S Samson, S Rosenschein, D Echenberg, A Ammann, J Levy. As of 11/16/84, 27 AIDS victims who had donated blood to the Irwin Memorial Blood Bank since 1/1/79 had been identified by comparing cases reported to the San Francisco Health Department vs the blood bank's donor files. Blood Components from these donors had been transfused into 121 different recipients. Sixty-four of these recipients are dead from their original or an unrelated illness and two from AIDS. |
| S13C | PREVALENCE AND SPECIFICITY OF ANTI-HTLV III IN HIGHLY TRANSFUSED PEDIATRIC PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S13C Alan Williams, NLC Luban, K Williams, A Bodner, R Dodd. These data suggest that the specificity of anti-HTLV ELISA reactivity in highly transfused individuals must be confirmed and that the risk of HTLV III infection from massive exposures to RBC and platelet products may be low. |
| S13D | IGG-LAV-ANTIBODIES IN HAEMOPHILIACS: ROLE OF AMOUNTS AND ORIGIN OF BLOOD PRODUCTS. POSSIBLE PREVENTION OF LAV-TRANSMISSION BY USING HEAT-TREATED PRODUCTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S13D Christine Rouziox, Françoise Brun-Vezinet, MA Rey, JP Allain. The occurence of AIDS in haemophiliacs raised the question of the blood products in the transmission of LAV: in France, haemophiliacs are treated with either domestic preparations of factor VIII or IX, or a mixture of domestic and imported products (mainly from USA). IgG antibodies to LAV (LAV-AB) have been, detected by ELISA. |
| S14A | BACTERIOLOGY OF MYCOBACTERIAL ISOLATES FROM PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S14A Robert C Good, MA Yakrus, JO Kilburn, VA Silcox, and WD Jones. Studies of biochemical reactions of the isolates have not suggested a specific biovariant of MAC or MTB as the infecting strain. Properties of MAC that would favor their occurence in disseminated infections in AIDS patients have not yet been identified. |
| S14B | BACTEREMIA DUE TO MYCOBACTERIUM TUBERCULOSIS (MTB) AND MYCOBACTERIUM AVIUM INTRACELLULARE (MAI) IN HOMOSEXUAL MALES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S14B Timothy P Mess, WK Hadley, CB Wofsy. From January 1983 to September 1984, 35 homosexual males seen at San Francisco General Hospital had culture proven disseminated mycobacterial infections: MTB-10, MAI-25. Of these, blood cultures were positive in 3/10 MTB and 18/25 MAI. Mean days to preliminary and final identification were 25.3 and 53.0 for MTB and 24.2 and 59.6 for MAI. Charts could be reviewed in 3/3 MTB and 9/18 MAI. A prior diagnosis of AIDS was established in 1/3 MTB and 8/9 MAI. Mycobacterial lung disease was present in 1/3 MTB, 3/9 MAI. Age and presence of systemic symptoms were similar in both groups. |
| S14C | MYCOBACTERIUM AVIUM COMPLEX (MAC) FROM AIDS PATIENTS: IN VITRO SUSCEPTIBILITY AND EVALUATION OF AN ANIMAL MODEL OF DISSEMINATED MAC INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S14C Lowell S Young, CB Inderlied, JK Yamada, MA Bertram, S Yadagar, DA Bruckner. MAC frequently causes disseminated infection in AIDS patients and existing therapeutic drug regimens are rarely efficacious. Radiometric susceptibility tests and a novel method of analysis led to the identification of new drugs and the evaluation of established drugs with activity against MAC. |
| S14D | ANSAMYCIN LM427 THERAPY IN AIDS PATIENTS WITH MYCOBACTERIUM AVIUM (MAI) COMPLEX INFECTION: A PRELIMINARY REPORT. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S14D RJ O' Brien, MA Lyle, HW Johnson, DE Snider. Although follow-up information is incomplete, approximately one-third of the patients showed some response to therapy but eradication of MAI infection was uncommon. Of patients eligible for randomization, those receiving the 300 mg ansamycin dose appeared to have a better short-term outcome than other patients. Clofazimine use did not appear to improve survival. However, conclusions about the efficacy of ansamycin therapy, optimal dose, and drug regimen await further analysis of available data and longer follow-up. |
| S15A | MECHANISM OF SERUM SUPPRESSION OF INTERLEUKIN 2 PRODUCTION IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S15A Jay P Siegel, NI Stocks, MA Wells, DB Burlington, and GV Quinnan. These findings indicate that AIDS sera suppress antigen- as well as mitogen-induced IL 2 production but they do not directly suppress IL 2-dependent proliferation, that the sera probably act directly on IL 2 producing cells, and that the sera act on an early stage of cell activation prior to the secretion of IL 2. |
| S15B | IN VITRO EFFECTS OF COMMERCIAL FACTOR VIII CONCENTRATES (FC)ON NORMAL IMMUNOCOMPENTENT CELL FUNCTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S15B Carolyn B Daul, MY Mann, W A Andes, & RD deShazo. These results suggest that commercial FC contain a factor(s) other than HTLV-III which inhibits proliferative responses of normal lymphocytes. Efforts to isolate this factor(s) are currently in progress. |
| S15C | FLOW CYTOMETRIC ANALYSIS OF LYMPHOCYTE PHENOTYPES IN AIDS AND OTHER RELATED HIGH RISK GROUPS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S15C Conrad Casavant, D Stites, T McHugh, A Moss. These abnormalities were most apparent when healthy homosexual males were compared to LAN patients. Phenotypic changes in AIDS and related risk groups suggest an immune imbalance of killer/cytotoxic activity and not solely immunosuppression. This increased activity could also represent an adaptive response to infection with a Retrovirus. |
| S15D | REGRESSION AS A MEASURE OF EBV-SPECIFIC T CELL CYTOTOXICITY IN AIDS, AIDS-RELATED COMPLEX (ARC) AND NORMAL HOMOSEXUAL MEN COMPARED WITH HETEROSEXUAL CONTROLS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S15D Alison C Mawle, JA Scheppler-Campbell, JS McDougal. These data demonstrate a defect in HLA-restricted killing of virally infected cells in patients with AIDS and ARC. It is not clear at this time whether the defect lies in the induction phase or the effector phase of the response. |
| S16A | EARLY NATURAL HISTORY OF HTLV-III ANTIBODIES IN PERSONS WITH HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S16A M. Elaine Eyster, JJ Goedert, W; Sarngadharan, SH Weiss, RC Gallo, WA Blattner. The association of lymphadenopathy and low helper T-cell counts with a long incubation period after the appearance of HTLV-III antibodies suggests an ongoing indolent process rather than an acute infection in most patients. It is not vet known whether this process is an aberrant part of the immune response initiated by HTLV-III antigens, or the result of a chronic active HTLV-III infection. |
| S16B | HEMOPHILIA IMMUNODEFICIENCY: INFLUENCE OF EXPOSURE TO FACTOR VIII, HUMAN T LEUKEMIA VIRUS (HTLV III) AND HERPES VIRUSES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S16B John L Sullivan, FE Brewster, DB Brettler, AD Forsberg, SH Cheeseman, PH Levine. These studies demonstrate that treatment of hemophilia with Factor VIII concentrate is associated with long-term immunoregulatory defects and that exposure to HTLV III plays a role in producing further defects. |
| S16C | DEVELOPMENT OF ANTI HTLV-III ANTIBODIES AND LYMPHOCYTE SUBSET MARKERS IN HAEMOPHILIACS FOLLOWING TRANSFUSION OF A SINGLE BATCH OF FACTOR VIII CONCENTRATE PRESUMED TO CONTAIN HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S16C Christopher A. Ludlam, J. Tucker, RS Tedder, ID Philp, CM Steel. This study describes the development during 1984 of antibodies to HTLV-III in a population of haemophiliacs not exposed previously to this virus. Of the 16 patients who developed specific antibody, 15 received a common batch of factor VIII concentrate. One patient developed a florid glandular fever like syndrome. A further 17 patients were transfused with the same batch but apparently failed to develop specific antibodies. In 1983 all 32 patients studied were seronegative for HTLV-III and. both T helpers and T helper/suppressor ratios were reduced. The patients' lymphocyte subsets were retested in 1984 several months after 15 had seroconverted. There was no difference in the lymphocyte parameters between those who developed anti HTLV antibodies and those who remained seronegative. |
| S16D | RISK OF EXPOSURE TO HTLV-III/LAV AND TYPE OF CLOTTING FACTOR USED IN HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S16D Gene McGrady, G Gjerset, S Kennedy. Although the risk of exposure to HTLV-III/LAV is significantly lower in those using cryoprecipitate only, both the initial seroprevalence (31%) and the rate of seroconversion (l8%/year) are much higher than expected. Recommendations that certain patients be treated with cryoprecipitate may need to be reconsidered in light of these data. |
| S16E | A SEARCH FOR HTLV-III AND ITS ANTIBODIES IN HEMOPHILIC FAMILIES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S16E JJ Goeoert, ME Eyster, AJ Bodner, SH Weiss, RC Gallo, WA Blattner. These results will provide quantitative data on the risk of transmitting HTLV-III from healthy seropositive hemophiliacs to their wives. |
| S17A | TREATMENT OF M. AVIUM-INTRACELLULARE INFECTION IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S17A Catherine Hawkins, TE Kiehn, E Whimbey, JWM Gold, AE Brown, D Armstrong. M. avium-intracellulare (MAI) infection in patients with AIDS is common and difficult to treat. The clinical course of 35 patients with AIDS and MAI infection documented by a positive culture from a sterile body site was reviewed to assess their response to treatment. Cultures of blood were positive in 30 of 31 patients. In others, the diagnosis was made by bone marrow culture in 3, and liver biopsy in 2. |
| S17B | SEROLOGIC RESPONSE TO CRYPTOSPORIDIUM DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S17B Beth LP Ungar, R Soave, R Fayer, TE Nash. Cryptosporidium is an intestinal parasite associated with limited diarrhea in immunocompetent hosts and fulminant diarrhea in immunocompromised (particularly AIDS) patients. We developed a sensitive and reproducible ELISA using Cryptosporidium oocysts as antigen for detection of Immunoglobulin G (IgG) or IgM serum antibody to Cryptosporidium. |
| S17C | NEUROLOGICAL COMPLICATIONS OF AIDS: AN OVERVIEW BASED ON 110 AUTOPSIED PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S17C BD Jordan, BA Navia, E-S Cho, CK Petito, Richard W Price. We reviewed the autopsy and clinical records of 110 patients who died in our hospitals over a 3.5-year period. Only 19 patients had unremarkable pathology other than agonal changes. Most common among the AIDS-related findings were scattered microglial nodules (MGN), noted in 74 patients; these were the exclusive abnormality in 51. |
| S17D | DIAGNOSTIC STUDIES FOR TOXOPLASMOSIS IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S17D Milford N Lunde, C Wanke, HC Lane, AS Fauci, E Gelmann, H Masur. The correlation of routine histopathology, immunoperoxidase staining, mouse inoculation, serology,and response to antitoxoplasma therapy has been assessed. The results suggest that serology is not useful diagnostically, that organismsare difficult to see by routine histologic examination of needle biopsies, and that both immunoperoxidase staining and mouse inoculation are useful diagnostic techniques. |
| S17E | SIMULTANEOUS SHIGELLOSIS AND CYTOMEGALOVIRUS (CMV) COLITIS IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S17E Evan T Bell, HZ Rotterdam, and ML Tapper. Response to anti-Shigella therapy was poor with only one patient obtaining significant symtomatic improvement. In 3 pts, Shigella persisted in stool cultures 4 weeks after appropriate antibiotic therapy. The occurrence of shigellosis in pts at risk for AIDS, especially if associated with features atypical for Shigella infection should prompt further evaluation for coexistent CMV colitis. |
| S18A | DEFECTIVE C3B RECEPTOR-MEDIATED CLEARANCE IN PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18A Bradley S. Bender, SH Sourlis, MM Frank, JF Bohnsack, TC Quinn. These data demonstrate a general RES dysfunction which may contribute to the dissemination of OI in AIDS. |
| S18B | CELLULAR AND HUMORAL RESPONSES TO PNEUMOCYSTIS CARINII (PC) IN AIDS AND INMUNO-COMPROMISED HOMOSEXUALS (ICH). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18B B Hofmann, N Ødum, P Platz, PB Nielsen, WH Andersen, JO Nielsen. In conclusion, most normal controls show a positive response, while AIDS patients and most ICH do not respond in L T to PC. The response could not be restored by TCGF. AIDS patients without PC infection and most ICH have IgM anti-PC antibodies whereas AIDS patients with PC infection lack 19M antibodies to PC. This may indicate a protective role of IgM antibodiesto PC infection. |
| S18C | IMMUNOHISTOCHEMICAL STUDIES OF T-CELL SUBSETS IN PATIENTS WITH PERSISTENT GENERALIZED LYMPHADENOPATHY(PGL). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18C Nora CJ Sun, JB Hannah, M Colman, A Jacobs and W Coulson. These results were compared with a control group (four tonsils and three reactive lymphnodes). It was found that the most severe inversion of T4/T8 ratio was in the GC (controls 4.5, FH 0.7, mixed 0.3, KS 0.2), followed by the HZ (controls 1.4, FH 0.6, mixed 0.5, KS 0.4), and PC (controls 1.5, FH 1.0, mixed 0.8, KS 0.7). In addition, the total T4/T8 was correlated with the histologic types, with the lowest T4/T8 in KS group (0.57), followed by the mixed pattern (0.69), and FH (0.87), in comparison to the control group of 1.39. |
| S18D | IMMUONLOGIC PROFILE OF AIDS AND OTHER PARASITIC INFECTIONS IN AFRICA AND THEIR RELATIONSHIP TO HTLV-III INFECTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18D Henry Francis, J Mann, T Quinn, J Curran, BM Kapita. Preliminary results suggest a greater prevalence of HTLV-III antibody among AIDS patients compared to patients with other infections and health controls. In addition, a significant number of patients with tuberculosis show a greater prevalenceof HTLV-III compared to health controls. Immunologic studies suggest a direct correlation between seropositivity to HTLV-III and depressed. T-Helper cells (less than 400/mm³) and reversed T-Helper to T-Suppressor cell ratio (less than 0.9) in these diseases. |
| S18E | STUDIES ON SURFACE PHENOTYPES AND FUNCTIONS OF PBMC IN PATIENTS WITH AIDS BEFORE, DURING, AND AFTER A 14 DAYS TREATMENT WITH RIL-2. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18E Martin Ernst, P Kern, H-D Flad, J Ennen, AJ Ulmer, M Gruber. From these results we conclude that rIL-2 treatment of AIDS patients leads to at least transient phenotypic and functional changes in all important leukocyte subpopulations, namely in T cells, B cells, NK cells, monocytes,and granulocytes. |
| S18F | IMMUNOBIOLOGY OF AIDS: REQUIREMENT FOR SIMULTANEOUS DEFECTS OF ADAPTIVE AND NATURAL IMMUNITY IN THE PATHOGENESIS OF OPPORTUNISTIC INFECTIONS (OI). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S18F Frederick P Siegal, C Lopez, P Fitzgerald, I Leiderman, P Baron. Patients were followed serially for up to 30 months, during which 31 progressed to OI. Data from these subjects indicate that critically low values for some measurements of T cell function and for IFNAGN are reached in the months or weeks prior to developmentof OI and can be considered predictive. Such data permit the anticipation of, and the institution of chemoprophylaxis for, some OI. They also indicate that two important and apparently independent components of the host defense must be damaged before OI can occur. |
| T-1 | HTLV-III IN THYMUS OF A PREMATURE CHILD. BORN TO MOTHER WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-1 Drasko D Pekovic, JP Chausseau, N Lapointe, J Michaud, JM Dupuy. Presence of HTLV-III in thymus of 3 normal subjects and in that of a premature child, born to a mother with AIDS, was searched for using immunofluorescence technique. The child was born by Cesarian section after 22 weeks of gestation. The mother died from AIDS two hours after delivery, and the child died 3 weeks later from brain hemorrhage. The thymus of the child was obtained at post-mortem. |
| T-2 | DETECTION OF HTLV-III IN PERIPHERAL BLOOD LYMPHOCYTES OF AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-2 Drasko D Pekdvic, JP Chausseau, N LaPointe, J Michaud, C Tsoukas, H Goldman, N Gilmore, JM Dupuy. HTLV-III antigens were searched for in sections of peripheral blood lymphocytes (PBU of normal subjects and AIDS patients by means of immunofluorescence technique and electron microscope immunocytochemistry. For IF studies, PBL were embedded in agarose, frozen in liquid nitrogen, and sectioned in a cryostat. For EM examination, the PBL were embedded in bovine serum albumine, mounted into an epoxy-resin, and sectioned in an ultramicrotome. |
| T-3 | RETROVIRUS PARTICLES IN ESOPHAGEAL BIOPSIES IN LYMPHADENOPATY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-3 KK Wong, DM McLean, L Rabeneck. Retrovirus particles 100-130 nm total diameter with electron-dense nucleoids 60-70 nm diameter surrounded by crenated double-layered outer coats were observed adjacent to mitochondria, budding from esophageal epithelial cell surfaces, and extracellularly in all patients, but not in two control patients with alcoholic gastritis in the absence of the above syndrome. Electron micrographs will demonstrate the morphological features of retrovirus particles in 3 patients. |
| T-4 | ESOPHAGEAL ULCERS CONTAINING ENVELOPED VIRAL PARTICLES IN HOMOSEXUAL MALES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-4 Linda Rabeneck, DM McLean, WJ Boyko, WA McLeod, KK Wong. In summary, an illness characterized by esophageal ulcers, skin rash and oral ulcers is described in 8 homosexual males. The cause of the ulcers is likely the enveloped viral particles observed at electron microscopy. |
| T-5 | REVERSE TRANSCRIPTASE ACTIVITY IN SEMINAL FLUIDS FROM PATIENTS WITH AIDS AND FROM A NORMAL HETEROSEXUAL MALE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-5 Michael S Borzy and AA Kiessling. These results suggest that the male reproductive tract of humans may be a reservoir of retrovirus expression. |
| T-6 | HTLV-III, LYMPHADENOPATHY AND THRUSH: PROSPECTIVE STUDY OF HOMOSEXUAL MEN AT HIGH AND LOW RISK FOR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-6 Jonathan WM Gold, LN Baker, J Dryjanski, AB Ley, WR Oleszko, D Armstrong. Three hundred ten homosexual men are being prospectively studied in New York City where AIDS is endemic, and in Ithaca, New York where AIDS has not occurred. |
| T-7 | SEROLOGIC, IMMUNOLOGIC AND CLINICAL FEATURES OF I.V. DRUG ABUSERS WITHOUT AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-7 E Emeson, I Spigland, S Weiss, A Bodner. This study found two populations with very different risks. Seven of 13 hospitalized IVDA and only 1 of 20 healthy outpatients developed AIDS or ARC. |
| T-8 | ANTIBODIES TO HTLV III IN SWISS PATIENTS WITH AIDS, AIDS RELATED COMPLEX (ARC), AIDS RISK AND IN REFUGEES FROM CENTRAL AFRICA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-8 Markus W Vogt, J Schuepbach, R Bhushan, R Luethy, M Glauser, B Hirschel. We conclude, that Swiss patients with AIDS and many individuals with ARC and AIDS risk and some healthy refugees from central Africa show evidence of HTLV III infection. While ELISA may be useful for screening purposes in blood banks, it should not be used for the confirmation of HTLV III infection. |
| T-9 | PREVALENCE OF ANTIBODIES TO ARV/LAV-1 IN AFRICAN PATIENTS WITH KAPOSI'S SARCOMA PRIOR THE EPIDEMIC OF AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-9 G. Giraldo, E Beth Giraldo, JA Levy and JC Chermann. Preliminary results indicate an absence of ARV and only a sporadic occurrence of LAV-1 in KS patients prior the epidemic of AIDS. Data obtained will be discussed, particularly in view of a 2-virus model for AIDS/KS. |
| T-10 | MOLECULAR CHARACTERIZATION OF HTLV-III IN AIDS: CLONING AND ANALYSIS OF VARIANT VIRAL GENOMES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-10 BH Hahn, GM Shaw, MA Gonda, SK Arya, M Popovic, RC Gallo, and F Wong-Staal. These findings have important implications concerning the biology and evolution of HTLV-III. |
| T-11 | AIDS AND CYTOMEGALOVIRUS EXPOSURE IN NEW YORK CITY DRUG ABUSERS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-11 Michael Marmor, D Des Jarlais, T Spira, S Friedman, H Cohen, S Yancovitz. We conclude that CMV is not a cause of AIDS-related immunologic abnormalities. A role for CMV as a co-factor for AIDS/KS is supported by CMV seropositivity rates that are lowest in male drug abusers, intermediate in female drug abusers, and highest in male homosexuals, which is the same ordering as proportional morbidity due to AIDS/KS in these risk groups. |
| T-12 | ORAL "HAIRY" LEUKOPLAKIA SHOWS EVIDENCE OF BOTH PAPILLOMAVIRUS AND EPSTEIN-BARR VIRUS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-12 JS Greenspan, D Greenspan, ET Lennette, M Conant, D Abrams and V Petersen. Leukoplakia of the tongue in male homosexuals ("hairy" leukoplakia-HL) is a distinctive lesion with features suggesting the involvement of papillomavirus. To pursue this hypothesis, ultrastructural studies were performed on 20 cases selected from the 77 which we have seen. Electronmicroscopy of biopsy samples from cases of HL revealed sporadic papillomavirus particles in 15/20 specimens. |
| T-13 | ADENOVIRUSES IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-13 Jonathan WM Gold, J Hierholzer, D Armstrong. Disseminated infections with cytomegalovirus are found in nearly all patients with AIDS, and severe ulcerative rectal herpes simplex infections are also major complications. Adenoviruses (AV) are also frequently isolated from AIDS patients, but rarely cause disease. We have cared for 302 patients with AIDS: 113 have died and complete autopsies including viral cultures have been done in 75. |
| T-14 | DETECTION OF HUMAN CYTOMEGALOVIRUS (HCMV) DNA IN LEUCOCYTE SUBPOPULATIONS OF HOMOSEXUAL MEN WITH AIDS AND ARC. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-14 Stepben A Spector, JA McCutchan, JE Lavine, J Love, and DD Richman. These data indicate that HCHV DNA is detected frequently from leucocytes and leucocyte subpopulations of AIDS, ARC and AH pts and that the lymphocyte subpopulation malt frequently infected with HCHV is diminished in AIDS pts. |
| T-15 | EPSTEIN-BARR VIRUS INFECTIONS IN PRE-ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-15 Ciro V Sumaya, Y Ench, RN Boswell, C Moore, D Kisner. These results demonstrated an enhanced antibody response to EBV antigens and an increased load of EBV in oropharyngeal secretions and peripheral blood leucocytes of pre-AIDS patients compared to normal adults tested. |
| T-16 | INFECTION WITH MULTIPLE GENOTYPES OF EB VIRUS (EBV) IN AN INFANT WITH AIDS AND HIS MOTHER. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-16 Ben Z Katz, Warren A Andiman, George Miller. These results indicate that, at least in AIDS patients, simultaneous infection with more than one strain of EBV is possible. Whether this is also true of immuno competent hosts is presently unknown. The data also raise the possibility of vertical transmission of EBV from mother to infant. |
| T-17 | INDIRECT FLUORESCENT ANTIBODY (IFA) FOR HSVI HSV2 CMV EBV AND HTLV I II III IN AIDS, AIDS RELATED AND NORMAL SERA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-17 Sean P. O'Neill, FK Mundon, RP Stone, EM Hersh, JM Reuben,PWA Mansell. The data suggest a relationship does exist and points out a definite need for a prospective study to determine which came first, the herpes or the AIDS. |
| T-18 | SEROLOGIC EVIDENCE OF EPSTEIN BARR VIRUS (EBV) INFECTIONS BY INDIRECT IMMUNOFLUORESENCE (IF) AND ELISA TECHNIQUES IN ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-18 Keith M Ramsey, and RB Pollard. We conclude that (1) serologic evidence of active Epstein-Barr virus infections is present among a majority of AIDS cases, and (2) ELISA techniques to detect the presence of specific antibodies to the Epstein-Barr virus in AIDS represent an alternative to the immunofluoresence techniques currently in use. |
| T-19 | SOME NOVEL STATISTICAL AND VIROLOGICAL METHODS FOR DISTINGUISHING CAUSATION FROM OPPORTUNISM IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-19 Roulette W Smith. These theories reveal the need for distinguishing causation from consequence in AIDS. Moreover, quantitative theories defy the Henle-Koch postulates and other inoculation and transmission methods employed in virology. Two methods now have been devised providing necessary (though not sufficient) conditions for the explication of causation and opportunism in AIDS. A novel time-series analysis based on classic models of slow infections may resolve several epidemiological and ethical dilemma posed by AIDS. Modifications to the Henle-Koch postulates to account for unique aspects of AIDS also are proposed. These methods should be useful in the search for causes of AIDS. |
| T-20 | IMMUNOLOGICAL RESPONSES TO EPSTEIN-BARR VIRUS (EBV) IN HEALTHY HOMOSEXUAL MEN AND IN HOMOSEXUAL MEN WITH AIDS AND AIDS-ASSOCIATED DISORDERS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-20 Helen Lipscomb, J Sonnabend, S Saadoun, D Purtilo. EBV may play an important etiological role in induction and pathogenesis of AIDS and AIDS-related syndromes. Since 1982, we have studied immune function in over 500 homosexual men from New York and Omaha. EBV serologic data was obtained on control adult heterosexual men, 68 homosexual men from Omaha, and 240 homosexual men from Greenwich Village, NY. EBV seropositivity was 91% in controls, 98% in healthy Omaha homosexual men, and 100% in homosexual men from New York. |
| T-21 | A NEW T CELL LINE DEVELOPED FOR THE STUDY OF AIDS RETROVIRUSES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-21 T Folks, S Benn, M Lightfoote, M Martin, D Hoggan, K Sell. The histopathology of the infected A3.01 cell line appears similar to infected PBL's showing large syncitia with multiple nuclei, and budding retrovirus particles by EM. Southern blot analysis using a cloned viral DNA probe reveals similar HCRV restriction fragments in infected A3.01 cells and infected PBL's. This cell system offers an alternative to other AIDS retrovirus cell systems for detection of viral cytopathic effects and serves as an in vitro model for the study of the cellular biology of AIDS. |
| T-22 | CONTINUOUS PRODUCTION OF A CYTOPATHIC HUMAN T-LYMPHOTROPHIC VIRUS III A PERMISSIVE NEOPLASTIC T-CELL LINE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-22 Jane P Getchell, JL Heath, DR Hicks, R Narayanan, CR McGrath, C Bohan, VS Kalyanaraman. Soon after infection with HTLV-III/LAV isolates, more than 90%, of the cloned HUT-78 cells lysed; the remaining cells continued to grow. More than 80%, of these cells expressed HTLV-III/LAV antigens by immunofluorescence. The extracellular virus of the chronically infected cell line was shown to be similar to other HTLV-III/LAV isolates by competition radioimmunoassay, by reactivity with human sera, and by nucleic acid hybridization. The development of the HTLV-III/LAV-infected immortalized cell line enables the continuous production of large amounts of virus. It will no longer be necessary to infect large numbers of human T-cells to obtain large quantities of virus for molecular and immunologic analyses. |
| T-23 | A CONTINUOUS LYMPHOCYTE CULTURE PRODUCING HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-23 Jukka Suni, S Turtiainen, E Taskinen, P Partanen, S-L Valle, A Vaheri. HTLV-III is known to infect primarily T helper cells. There is, however, evidence that HTLV-I and HTLV-III may also infect B lymphocytes. The infection of B lymphocytes by HTLV-III has been shown to be preceded by EBV infection of the same B lymphocytes. |
| T-24 | PRODUCTION OF HUMAN-HUMAN HYBRIDOMAS SECRETING ANTIBODY SPECIFIC FOR HTLV-III/LAV. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-24 Alison C Mawle, DD Moore, MS Kennedy, JS McDougal. We have attempted to produce human-human hybridomas secreting antibodies directed against the proteins of HTLV-III/LAV. |
| T-25 | IMMUNOASSAY FOR THE DETECTION OF HTLV-III/LAV AND ITS APPLICATION TO A MICROCULTURE ASSAY METHOD FOR QUANTITATION OF INFECTIOUS HTLV-III/LAV (ID-50 ASSAY). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-25 J Steven Mc Dougal, SP Cort, MS Kennedy, LS Martin, A Mawle, J Sligh, CD Cabradilla, PM Feorino, DP Francis, D Hicks, BM Jones, VS Kalyanaraman. The ID-50 assay is several orders of magnitude more sensitive for small amounts of virus than is either the capture assay or the RT assay. We have demonstrated its application to disinfectant evaluation, neutralization experiments, HTLV-III/ LAV cell tropism studies, and rapid viral isolation. |
| T-26 | ISOLATION OF RETROVIRUSES FROM INDIVIDUALS WITH AIDS-RELATED CONDITIONS - A PRESPECTIVE STUDY IN THE NEW YORK CITY AREA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-26 Domenic Casareale, F Sinangil, D Purtllo, J Sonnabend, DJ Volsky. The frequent finding of retroviruses in the groups tested is consistent with previous reports. The common identity of our isolates is presently being established using immunochemical and recombinant DNA techniques, as is their identity with previously reported AIDS-related retroviruses, LAV/HTLV-III. Supported by CA37465. |
| T-27 | ISOLATION OF AIDS-ASSOCIATED RETROVIRUSES (ARV) FROM PATIENTS WITH AIDS AND FROM INDIVIDUALS AT RISK OF DEVELOPING AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-27 Joni Shimabukuro, T Kendrick, and JA Levy. Our laboratory has recovered over 70 different isolates of AIDS associated retrovirus (ARV) from patients and other individuals in San Francisco and elsewhere in the world. The viruses share similar morphology by electron microscopy, magnesium-dependent reverse transcriptase activity and cytopathic effects in lymphocytes. The isolates differ in their abilities to infect the human T cell line, HUT-78, and other established T lymphocyte cell lines including MOLT and CEM. |
| T-28 | RECOMBINANT INTERFERON ALPHA-A AND HTLV-III REPLICATION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-28 Kevan L. Hartshorn, DD Ho, JC Kaplan, T Rota, CA Andrews, RT Schooley. These studies indicate that HTLV-III is susceptible in vitro to interferon inhibition at levels ~64U/ml) easily achievable in vivo. |
| T-29 | EVIDENCE OF SEROLOGIC REACTIVITY TO HTL V-III AND SERUM INTERFERON ELEVATION IN SOME PATIENTS WITH AUTOIMMUNE DISEASE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-29 Max R Proffitt, L Calabrese, A Segal, B Yen-Lieberman. We recently participated in a clinical trial of a solid phase immunoenzyme assay (Litton Bionetics) for the detection of antibodies to the human retrovirus HTLV-III. Sera from normal blood bank donors (BBD), healthy homosexuals (HH), and from patients with Acquired Immunodeficiency Syndrome (AIDS), AIDS Related Complex (ARC), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS) and Polymyositis/Dermatomyositis (Pm/Dm) were studied. |
| T-30 | A HUMAN ENDOGENOUS RETROVIRUS RELATED MR 75000 PROTEIN EXPRESSED IN HTLV-III-INFECTED H9 CELLS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-30 Jukka Suni, A Närvänen, P Partanen, R Pakkanen, T Wahlström, A Vaheri. The HTLV-III-infected H9 cells expressed constantly the Mr 75000 protein whereas the uninfected H9 cells and other HTLV-I and HTLV-II producing cells were negative. |
| T-31 | ISOLATION OF HTLV-III AND EBV-POSITIVE B LYMPBOBLASTOID CELL LINES FROM PERIPHERAL BLOOD LYMPHOCYTES OF AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-31 DJ Volsky, F Sinangil, J Sonnabend and D Casareale. Peripheral blood lymphocytes from AIDS patients were cultured in the presence of PHA and IL-2. The majority of the cultures were found to contain HTLV-III/LAV, as determined by electron microscopy and the presence of reverse transcriptase (RT) in cell-free supernatants. Prolonged incubation resulted in the establishment of several IL-2-independent B-lymphoblastoid cell lines. |
| T-32 | ANALYSIS OF VIRAL PROTEINS IN THE T CELLS OF AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-32 Marilyn M Lightfoote, Thomas Folks, Douglas Powell, Esther Racoosin, Audrey Kinter, Kenneth W Sell. Lysates of an infected T cell line (3.01) were prepared and electrophoresed on gradient gels. Immune blots of these cellular components revealed the 18,000, 25,000 and 100,000 molecular weight proteins. Lysates of 3.01 cells which remained viable after infection with the retrovirus (but no longer produce viral particles) elicited immune blot responses to protein components of 25,000 and <100,000 molecular weight. |
| T-33 | PURIFICATION AND CHARACTERIZATION OF HTLV-III/LAV ISOLATED FROM PERIPHERAL BLOOD LYMPHOCYTES OF AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-33 Faruk Sinabgil, K Sakai, D Casareale and DJ Volsky. Cell free supernatants from one week-old cultures of CEM cells cocultivated with irradiated peripheral blood lymphocytes of AIDS patients from, New York City were found to be highly positive for reverse transcriptase activity. C-type virus particles and budding structures were demonstrated by electron microscopy. |
| T-34 | DO RETROVIRUS ISOLATES FROM SEVERAL AIDS PATIENTS HAVE ANTIGENIC DIVERSITY IN THEIR STRUCTURAL PROTEINS? Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-34 SG Devare, J Casey, J Getchell, R Narayanan, A Srinivasan, VS Kalyanaraman. The data suggest that individual retroviruses have significant restriction site polymorphism in their genome. This polymorphism is also reflected in the size of the structural protein of the virus. |
| T-35 | EXPRESSION OF AN HTLV-III GAG GENE ANTIGEN IN E. COLI. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-35 Carol J Marcus-Sekurfal, Flossie Wong-Staal, Robert C Gallo and Gerald V Quinnan, Jr. This, together with the mapping data, indicates that the antigen being expressed by pCMS3is a gag gene product. Comparison with nucleotide sequence data suggests we have cloned the right-hand portion of the gag gene containing the carboxyl terminal portion of p24. |
| T-36 | GLYCOSYLATED ANTIGENS OF HTLV-III INFECTED CELLS: EVIDENCE OF VIRAL ORIGIN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-36 Jonathan S Allan, JE Coligan, F Barin, TH Lee, W Haseltine, ME Essex. Our results suggest that gp160 may represent the envelope precursor protein and gp120, the mature exterior glycoprotein of HTLV-III. |
| T-37 | NEUTRALIZATION OF HTLV-III BY HUMAN SERUM. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-37 David D Ho, MG Sarngadharan, TR Rota, JC Kaplan, CA Andrews, MS Hirsch. No seronegative individuals showed neutralizing activity, whereas 14 of 15 seropositive samples had neutralizing titers of 1:2 to 1:10 or greater. We also found neutralization with 2 sera containing only antibody to p41, but not with 1 serum containing only antibody to p24. These studies show that infected individuals can develop HTLV-III neutralizing factors,which may be immunoglobulins that are specific for the p41 viral envelope protein. |
| T-38 | EPITOPES OF BOVINE LEUKEMIA VIRUS GP51 IN CULTURES OF LYMPHOCYTES FROM AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-38 Lise Thiry, S Sprecher-Goldberger, A Burny, D Portetelle, JP De Caluwe and N Clumeck. Preliminary results indicate that the pattern of epitopes expressed may vary from one patient to another. Consecutive isolates of the same patient are studied to detect antigenic stability during the course of the disease. |
| T-39 | SEQUENCE HOMOLOGY AND MORPHOLOGIC SIMILARITY OF HTLV-III AND VISNA VIRUS, A PATHOGENIC LENTIVIRUS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-39 Matthew A. Gonda, F Wong-Staal, RC Gallo, JE Clements, RV Gilden. These data provide strong evidence for a close taxonomic and thus evolutionary relationship between HTLV-III and the lentivirus subfamily of retroviruses. |
| T-40 | DISCRIMINATION OF PROPOSED DIAGNOSTIC TESTS FOR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-40 Alan Williams,C Conway, A Bodner, C Fang, H Paxton, R Dodd. Each of 51 sera from unselected AIDS/LAS patients and 8 healthy persons strongly suspected of having asymptomatic AIDS were reactive by anti-HTLV III ELISA and confirmed to be anti-P41 positive by western blot. Anti-P41 was confirmed to be negative in 131 non-AIDS hospitalized patients. |
| T-41 | COMPARISON OF THE CDC-451 AND LITTON-BIONETICS ASSAYS FOR THE DETECTION OF ANTI-HTLV-III/LAV AND THE ORTHO IMMUNE COMPLEX ASSAY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-41 Charles A Schable, JS McDougal, J Getchell, M Hubbard, D Hicks, L Wells. The CDC-451 and Litton-Bionetics kit are equally sensitive for the detection of antibodies to HTLV-III/LAV originating in patients with AIDS or associated conditions. The high correlation (p<.001) between the antibodies measured by the Litton kit and the CIC as measured by the Ortho kit are compatible with the viral syndrome of AIDS/ARC. |
| T-42 | DETECTION OF ANTI-HTLV ANTIBODIES BY FIXED CELL IMMUNOFLUORESCENCE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-42 Eric G Sandstrom, DD Ho, RT Schooley, MG Sarngadharan, RC Gallo, MF MacLane. These results suggest that fixed cell immunofluorescence provides a sensitive means of detecting anti-HTLV-III antibodies, comparable in reliability to Western blot or membrane immunofluorescence techniques. |
| T-43 | ANTIBODY TO AIDS ASSOCIATED RETROVIRUS IN PEDIATRIC PATIENTS WITH PRIMARY AND SECONDARY IMMUNODEFICIENCY DISEASES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-43 Arthur J. Ammann, Lawrence Kaminsky, Jay A Levy. Our results, based on antibody assays, indicate that: 1) antibody to ARV in pediatric immunodeficiency disorders is associated with a distinctive immunologic profile; 2) first appeared in 1978; 3) does not occur in other primary immunodeficiency disorders as an opportunistic infection. |
| T-44 | IGG ANTI-HTLV-III SERA FROM MALE HOMOSEXUALS CROSS REACTS WITH LAV. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-44 William M Mitchell, John W Black, Shirley S Schuffman, Robert E Keller, Reeky R Greene and Lewis B Lefkowitz. Sera from thirty homosexual male patients attending a Nashville based gay lifestyles clinic and twenty male pre-marital controls were examined for antibodies against HTLV-III (USA isolate) and LAV (French isolate) by indirect fluorescent microscopy. None of the control sera had demonstrable antibodies against cells producing HTLV-III or LAV at a 1:20 dilution. |
| T-45 | DETERMINATION OF HTLV-III ANTIBODIES IN 150 PATIENTS WITH AIDS, AIDS-RELATED DISEASES AND CONTROLS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-45 Fred C Jensen, W Cronin, D Triglia, HL Ioachim. Human lymphotropic retroviruses LAV/HTLV-III have been recently implicated in the etiology of the acquired immune deficiency syndrome (AIDS). In this work, 150 serum samples of patients with AIDS, AIDS-related complex (ARC), patients with diseases unrelated to AIDS and normal controls were screened for the presence of antibodies to HTLV-III. |
| T-46 | THE CONSEQUENCES OF PARENTERAL INJECTION OF AIDS-RELATED MATERIAL IN TO SMALL ANIMALS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-46 WJW Morrow, M Wharton, and JA Levy. In an attempt to establish an animal model for AIDS, mice, rats, hamsters and guinea pigs were injected with material from patients with AIDS. The inocula included whole blood, peripheral mononuclear cells, platelets, ultracentrifuged serum pellets and spleen cells. More recently, some animals were injected with purified AIDS-associated retrovirus (ARV). |
| T-47 | INFECTION OF CHIMPANZEES AND BABOONS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-47 Jorg W Eichberg, HJ Alter, JA Levy, J Morrow, JE Groopman and GR Dreesman. Eight chimpanzees and six baboons have been inoculated with specimens containing either the human T-cell leukemia virus type 3 (HTLV-3) or the AIDS associated retrovirus (ARV): 1. plasma from human AIDS patients contained either high titer anti-HTLV-3 antibodies but no detectable HTLV-3 virus when retrospectively checked 1½ years post-inoculation (p.i.), or no anti-HTLV-3 antibodies but HTLV-3 virus that was infectious for human lymphocytes in vitro, 2. whole blood containing ARV, or purified ARV alone, or autologous lymphocytes infected in vitro with ARV. |
| T-48 | PATIENTS WITH SELECTIVE IgA DEFICIENCY/AT HAVE ANTI HTLV 1-MA ANTIBODIES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-48 RH Tomar, DL Nelson, PA John, and B Poiesz. Previously we demonstrated that patients with pre-AIDS and AIDS had increased antibody titers to HTLV 1-Membrane Antigens (MA). We were concerned that this response might represent another secondary infection. Therefore, we surveyed a group of 58 subjects with primary immunodeficiencies for anti HTLV 1-MA. |
| T-49 | THERMAL STABILITY OF AIDS-ASSOCIATED RETROVIRUSES (ARV). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-49 Steven N Wyman, B Banapour, T Kendrick, J Shimabukuro, J Levy. These results differ from those obtained with the mouse xenotropic retrovirus in which complete disruption of virions occurs after 2 days and neither RT nor infectivity can be found in the culture fluids. |
| T-50 | SAFETY OF HUMAN BLOOD PRODUCTS: INACTIVATION OF RETROVIRUSES BY HEAT TREATMENT AT 60°C IN SOLUTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-50 Joachim Hilfenhaus, Rudolph Hauler, Robert Friis, Heinz Bauer. AIDS can be transferred to patients by blood transfusions or blood preparations, such as cryoprecipitates or factor VIII concentrates. |
| T-51 | TWO CASES OF ACQUIRED IMMUNO DEFICIENCY SYNDROME AFTER ALLOGENIC BONE MARROW TRANSPLANT: TRANSMISSION OF LAV/HTLV III BY HEALTHY MARROW DONORS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-51 E Gluckman, CH Rouzious, F Brun-Vezinet, E Vilmer, MA Ray. Those two cases raise the question of the eventual healthy carriers of the virus and suggest that bone marrow recipients should be considered at risk of AIDS. |
| T-52 | COMMUNITY-BASED STRATEGIES FOR AIDS PREVENTION AND OUTREACH. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-52 Caitlin C Ryan and Peter A Laqueur. The development of specialized outreach campaigns requires extensive community involvement, the participation of recognized community leaders in high-risk and non high-risk groups, specialized funding sources, and the utilization of supplementary service providers, such as, graduate interns in adult education, community service and social work. Essential to the success of the outreach plan is the involvement and active participation of minority high-risk members, and on-going evaluation of campaign strategies. |
| T-53 | CAN LEGISLATION TO CLOSE BATHHOUSES REDUCE AIDS INCIDENCE? AN EPIDEMIOLGIC ANALYSIS OF ATTRIBUTABLE RISK. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-53 Alan R Kristal. This analysis suggests that legislation to close bathhouses will have, at best, only small effects on AIDS incidence in San Francisco. |
| T-54 | ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) IN PRISON INMATES (PI) - MEDICO-LEGAL AND ECONOMIC IMPLICATIONS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-54 IC Guerrero, R Porwancher, K Black, A Koenigsfest. The expensive medical cost has to be justified to the taxpayers whose monies are spent for a criminal's illness. Question as to whether it is justified to grant medical clemency to PI with AIDS has been raised & if so,then other state agencies have to shoulder the burden if PI is pardoned. |
| T-55 | RECOMMENDED PRECAUTIONS FOR AIDS PATIENTS UNDERGOING HEMODIALYSIS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-55 Martin S Favero. There is an increasing number of patients with AIDS who develop end-stage renal disease and undergo acute or chronic hemodialysis. Because AIDS is transmitted by the blood-borne route in a manner similar to viral hepatitis B, there is a potential for disease transmission to other dialysis patients and staff members. |
| T-56 | NATIONAL GUIDELINES FOR THE NURSING CARE OF PATIENTS WITH AIDS IN THE UNITED KINGDOM. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-56 Marilyn D Marks. The need for cooperation with self-help groups and psychological and emotional support systems is highlighted in order to compile guidelines which are acceptable and safe for patients, those closest to them, and the staff caring for them. Future ways for assisting those caring for the AIDS patient both in hospital and home are suggested. |
| T-57 | DEVELOPMENTS OF HEALTH EDUCATIONAL ACTIVITIES CONCERNING AIDS IN THE USA AND THE NETHERLANDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-57 Marianne C Stadlander, Nelleke Wouters and Hans Adriaanse. Furthermore, the health education would not only pertain to the concrete risk behaviors, but also include reasons why these put persons at risk, thus enabling those concerned to adapt. The paper will contain a comparison of the American and Dutch HE-strategies. The impact of US-data is outlines, while recommendations for HE-professionals and laypersons conclude the contribution. |
| T-58 | NATIONAL NETWORKING IN THE GAY COMMUNITY IN RESPONSE TO AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-58 Frank Greenberg, C Ryan, P Paroski, B Goodman,J Richards. After the AIDS epidemic was recognized in 1979, local organizations were founded in gay communities in many major cities to raise money for patient care services, community education, and research. As the epidemic became more widespread, the need for communication between local groups became increasingly necessary. In August, 1982, the First AIDS Forum was held in Dallas, co-sponsored by the National Gay Task Force (NGTF) and the National Gay Health Education Foundation (NGHEF). This conference provided an opportunity for various groups to share their experiences and to discuss common problems. |
| T-59 | ORGANIZATIONAL MODEL FOR THE ESTABLISHNENT OF AN ACQUIRED IMMUNE DEFICIENCY SYNDROME LOCAL NETWORK TASK FORCE IN AN AREA OF MODERATE TO LOW AIDS MORBIDITY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-59 Michael G Ritchey. An Aim networking task force can be developed, and successfully implemented in cities or states of moderate to low AIDS morbidity. Initiative and coordination may emerge from any of 5 resources: private medicine, medical school, hospital, health department, or community organizations. Regardless of resource leadership, this task force must include all these local resources as available. The comprehensive scope of AIDS related activities possible through a local task force allows if not requires active multi-disciplinary participation from its members. |
| T-60 | AIDS PREVENTION: A THREE-YEAR, THREE-PHASE APPROACH. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-60 Michael B Wilson, K Sumrall, WA Scott, SP Timm, PWA Mansell. In early 1982, Houston health educators produced lifestyle moderation educational materials based upon then-known and speculated facts about AIDS. Year1/Phase1 relied only on dissemination of the basic information (using inherent fear) to stimulate attitude and behavior changes. Little appropriate change resulted. Year2/Phase2 concentrated on teaching specific techniques of "safe sex" (55) and making SS seem acceptable, gay-positive, pallitable (and fun). This phase produced an extremely high awareness level (79%), a high and significant shift in attitudes (63%), and a lower shift in behavior (42%). Finally, Year3/Phase3 expanded "safe sex" promotion to include eroticism/sensuality (making SS fashionable). |
| T-61 | PUBLIC HEALTH PROVIDERS AND COMMUNITY ORGANIZATIONS: WORKING TOGETHER TOWARDS AIDS PREVENTION/EDUCATION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-61 Dennis McDowell, WD Squyres, E Judy; V Ross, FC Johnson; and WG Brown. Research provides examples of successful relationships of this type and supports the conclusion that training public health providers in building relationships with community organizations can help forge the links in communication and cooperation that are vital to AIDS prevention/education efforts. |
| T-62 | HEALTH EDUCATION PLANNING FOR AIDS RISK REDUCTION IN THE GAY/BISEXUAL MALE COMMUNITY: USE OF THE PRECEDE FRAMEWORK. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-62 Robert K Bolan. Health education in AIDS risk reduction has been hindered both by incomplete behavioral epidemiology of AIDS and baseline prevalence studies of sexual associated behaviors in the homosexually active male population. This population has received messages for sexual behavior change with skepticism due to the prevailing societal intolerance of their lifestyles. Knowing the social and psychological significance of such behaviors in the individual gay/bisexual man is central to the development of effective educational campaigns for AIDS risk reduction. The PRECEDE analytic framework has contributed to the design of the high risk education program of the San Francisco AIDS Foundation. PRECEDE is an acronym for predisposing, reinforcing, and enabling causes in educational diagnosis and evaluation. |
| T-63 | NURSE SCREENING CLINIC FOR AIDS: THE SAN FRANCISCO GENERAL HOSPITAL EXPERIENCE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-63 Gayling Gee, G Carr, J Molaghan, T Moran, C Wofsy. The Nurse Screening Clinic at San Francisco General Hospital's Acquired Immunodeficiency Syndrome (AIDS) Clinic provides screening Services for populations ranging from "worried well" to high risk individuals with varying degrees of symptoms. Protocols and algorithms have been designed to provide registered nurses and nurse practitioners with guidelines to effectively screen for AIDS. |
| T-64 | DESIGNING AN EFFECTIVE AIDS PREVENTION CAMPAIGN FOR SAN FRANCISCO: RESULTS FROM THE FIRST PROBABILITY SAMPLE OF AN URBAN GAY MALE COMMUNITY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-64 Larry L Bye, Jeffrey C Henne, Rebecca C Quarles. Assessment of risk associated with various sex practices appears to be highly accurate at this point in time. A correlational analysis suggests that campaign messages emphasizing social acceptability of safe sex may be more effective than messages that stress only the risks of unsafe practices. In addition, messages about the pleasurability of safe sex alternatives may decrease the frequency of unsafe oral sex practices but probably will not effect the frequency of unsafe anal sex practices. Demographically, gay and bisexual men tend to be highly educated and upscale in occupation and income. San Francisco’s openly gay male community may constitute 40% of City's single male population. |
| T-65 | DEPRESSION AND REQUESTS FOR SEXUAL RISK REDUCTION GUIDELINES IN AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-65 Lori S Wiener, RH Dworkin, K Siegel. Our results indicate that requests for sexual risk reduction guidelines among AIDS patients are related to depression and not demographic or illness characteristics. Patients who are more depressed may need to be directly informed of risk reduction guidelines. |
| T-66 | SEXUAL ABUSE OF A CHILD BY AN ATTACKER WITH AIDS: MEDICAL AND PSYCHOLOGICAL CONSEQUENCES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-66 M Dianne Murphy, Sandra Loucks, and Ernest Fuson. A 13 y.o. male was abducted and forced into sexual acts which included fellatio and ejaculation of semen onto the patient's face and body. The attacker died 9 months later of gram negative sepsis and Pneumocystis carinii (PCP). Though a known homosexual with a history of lymphadenopathy and PCP, this information was not clearly revealed and intermittently denied until the abuser died. |
| T-67 | COORDINATION OF SOCIAL SERVICES FOR AIDS PATIENTS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-67 David J. Martin. In addition to the medical complications associated with AIDS, AIDS patients face a host of psychosocial stressors, including reaction to having a terminal disease, financial disability, and social ostracism. Early efforts of individuals concerned with the psychosocial sequalae of AIDS were devoted to determining which services were available and putting special services for AIDS patients in place. While a number of traditional and special social services currently are available to provide psychosocial services to persons with AIDS, coordination among these programs and information regarding use of such services has not kept pace with their development. |
| T-68 | PREVENTING PSYCHOLOGICAL DECOMPENSATION IN PERSONS WITH AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-68 Judy Macks, MSW and James Dilley, MD The goals of the program include strengthening the patients' support system while teaching specific skills and techniques to manage stress and cope with fluctuating moods and depression. In this way, patients are helped to confront the changes in their lives brought about by their diagnosis in a supportive environment and to take an active stance in learning to cope with their illness. |
| T-69 | A MODEL PSYCHOSOCIAL SERVICES AGENCY FOR PERSONS WITH AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-69 Sally Jue and Coleen Johnson. Despite education efforts, persons with AIDS continue to face discrimination and poor access to psychosocial services such as medical transportation, housing, psychiatric hospitalization, public and private social services. AIDS Project/Los Angeles has responded to this need by developing a comprehensive, extremely cost effective volunteer organization to meet the numerous needs of persons with AIDS. Two full-time staff social workers facilitate the work of 150 professional and nonprofessional volunteers who assist 250 clients. Services provided include psychosocial evaluations, crisis, individual, couples, group and grief therapy, advocacy with social services, practical assistance In the home, day care, transportation, food and shelter, legal, financial and insurance services, recreation and a self care manual. |
| T-70 | "A COMPARISON OF FORMATS, PRIORITIES, AND SOURCES OF FUNDING OF PSYCHO-SOCIAL SUPPORT SERVICES FOR AIDS PATIENTS, FAMILIES AND FRIENDS IN TEN METROPOLITAN CENTERS." Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-70 BJ Stiles. This report will be the first formal presentation of the findings of this national overview, currently underway and supported by philanthropic organizations attentive to the needs of the gay/lesbian community and public policy issues that are emerging as AIDS becomes more visible and more widespread. |
| T-71 | Acquired Immunodeficiency Syndrome (AIDS): The Biopsychosocial Approach to Alienation Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-71 Mary Ann Cohen, MD and Henry W Weisman, MD. The goal of the program is to improve the care of the person with AIDS by leans of a biopsychosocial approach that maintains a view of each individual as a member of a family and county who deserves a coordinated approach to care and treatment with dignity. Adult disciplinary team comprised of physicians with specialties in infectious disease, oncology and liaison psychiatry as well as social workers, nurses, discharge planners, respiratory therapist and nutritionist has let weekly for almost two years to provide support for patients families and staff. The team provides a means of identifying and treating psychosocial problem while coordinating care and enabling a comprehensive, dignified, Integrated humane approach to the care of the individual with AIDS. |
| T-72 | APPLICATION OF THE CHRONIC ILLNESS MODEL TO PEDIATRIC ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-72 Mary Boland, J Kereszter, J Oleske, MM Zabala, R Bobila. Experience in caring for children with AIDS has resulted in an improved ability to provide supportive medical care leading to a decreased mortality but a chronic morbidity. These children have multiple problems including poor weight gain, vision defects, speech deficits, and delayed development. Their parents/guardians are stressed due to the frequent infections, uncertain outcome of the disease and have difficulty maintaining competent parenting skills. These families require the comprehensive, coordinated approach to care that has been found effective for chronic illness. |
| T-73 | A SHORT COURSE FOR HOMOSEXUAL MEN DIAGNOSED WITH AIDS-RELATED COMPLEX (ARC) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-73 Rosemary A Barnes. An 8-week course was offered by a staff psychologist to homosexual men diagnosed with AIDS-related complex (ARC). The course was intended to provide medical information related to AIDS and ARC, discussion of the personal impact of the illness, peer support, stress reduction training and referral to other resources as needed. All candidates for the group were individually assessed prior to being accepted. The group consisted of weekly 2-hour meetings for 8 patients, A physician attended 2 meetings. |
| T-74 | FEAR OF AIDS AND RATES OF GONORRHEA IN DENVER, COLORADO. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-74 Franklyn N. Judson, FI LeMaster. We conclude that owing to fear of AIDS, homosexual men are choosing more conservative sexual life styles which result in much lower rates of gonorrhea and other STD. |
| T-75 | PSYCHOSOCIAL AND NURSING CARE OF THE PERSON WITH A.I.D.S. DURING ADVANCED DISEASE, AND EMOTIONAL SUPPORT OF THEIR FAMILY AND SIGNIFICANT OTHERS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-75 Jerold S. Cohen, Mary Fugate. The class discusses the emotional needs of the patient, their family and the care giver. The role of the care giver is important and needs to be given consideration separate from the patient, The care giver is provided with a list of local organizations to turn to for additional support if required by the family |
| T-76 | EVIDENCE FOR INFECTION WITH HUMAN T-LYMPHOTROPIC VIRUS/LYMPHADENOPATHY-ASSOCIATED VIRUS (HTLV-III/LAV) IN FAMILIES OF CHILDREN WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-76 Jonathane Kaplan, JM Oleske, JP Getchell, AB Minnefor, K Zabala-Ablan, R Bobila. In households in which intravenous drug abuse, homosexuality or bisexuality, and prostitution occur, HTLV-III/LAV infection rates in household contacts of children with AIDS may be high. However, the negative findings in household contacts without risk factors for AIDS suggest that horizontal trsnsmission of the virus within households by means other than sexual contact must be infrequent. |
| T-77 | IGG LAV (LYMPHADENOPATHIC ASSOCIATED VIRUS) ANTIBODIES IN FAMILIES OF HAITIAN AND ZAIRIAN AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-77 Sophie Matheron, C Michon, B Moriniere, C Rouzioux, F Brun-Vezinet, JP Coulaud. From June 1981 to December 1984, 36 patients admitted in our clinical ward met the criteria for AIDS. Twelve were from intertropical areas: (3 from Haiti, 8 from Central Africa, 1 fom Guyana) None of the previously described known-risk factors was found in 10 of them (1 was homosexual, and 1 was transfused 4 years before onset of the disease). |
| T-78 | COMMUNICABILITY AIDS IN A FOSTER CARESETTING. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-78 Edward B Lewin, Ronald Lack, Ayotunde Ayodele. Department of Pediatrics, Henry ford Hospital, Detroit, 11,1. Ouestions regarding the transmissibility of AIDS are of special interest to families who must care for infants with AIDS. We have studied a foster family and the biologic parents of an 8 month old with AIDS (T4/T8=0.7; HTLV-III antibody +) to track the footprints of the HTLV-III virus in this cohort. Mother and father are IV drug abusers. |
| T-79 | SEXUAL TRANSMISSION OF LAV IN AMERICAN MEN AND WOMEN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-79 H Burger, B Weiser, WS Robinson, J Lifson, C Rouzioux, JC Chermann. To trace the sexual transmission of the lymphadenopathy associated virus (LAV), we studied 26 men and women from California at increased risk for AIDS, including 13 sexual partners of patients with AIDS and 9 long-term couples. In 2 couples heterosexual transmission of LAV from seropositive men at increased risk to their monogamous wives, who had no other AIDS risks, apparently occurred. In one couple the man had hemophilia A, developed LAS and later AIDS. |
| T-80 | SEXUALLY-LINKED CLUSTERS OF ZAIRIAN PATIENTS WITH AIDS SUGGESTING BIDIRECTIONAL HETEROSEXUAL TRANSMISSION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-80 H Taelman, F Feinsod, J Sonnet, Kapita BM, N Clumeck, P Piot. Male to female ratio near to 1 and the lack of known risk factors in African patients affected with AIDS strongly suggest heterosexual transmission of this disease in Central Africa. In order to document this hypothesis,a search for clusters of AIDS patients heterosexually linked was made in Belgium and Zaire. |
| T-81 | COMPARISON OF HTLV-3 SEROLOGY, T CELL LEVELS, AND GENERAL HEALTH STATUS OF CHILDREN WHOSE MOTHERS HAVE AIDS WITH CHILDREN OF HEALTHY INNER CITY MOTHERS IN NEW YORK Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-81 Pauline A Thomas, Katlyne Lubin, Roger W Enlow, Jane Getchell. Although AIDS has been shown to be transmitted from mother to child, this appears to occur either in utero or perinatally. Usually illness has occurred within 3 years prior to mothers onset of illness. We examined the hypothesis that horizontal transmission to children does not occur and that older children living with their mothers but born prior to the theoretic incubation of the mother, should be disease-free. We studied 17 children aged 3 to 11 of 9 mothers with AIDS, 55 unmatched control children of 36 healthy mothers. |
| T-82 | EVALUATION OF HOUSEHOLD CONTACTS OF ADULT PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-82 Margaret A Fischl, G Dickinson, G Scott, N Klimas, M Fletcher, W Parks. These data suggest heterosexual spread among spouses with a striking difference between men and women, in utero or perinatal spread to infants and mild clinical and immunologic abnormalities along several older children. No spread to older children from younger siblings with AIDS or ARC were noted. |
| T-83 | RISK FACTORS IN PEDIATRIC AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. T-83 JH Joncas, N LaPointe, MV O'Shaunghnessy, and P Gill. These findings strongly suggest that the source of HTLV-3 infection in our pediatric cases of AIDS is an infected mother or an infected blood donor. |
| S19A | INHIBITION OF GRANULOPOIESIS BY AN AIDS RELATED GLYCOPROTEIN Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S19A Ira Z Leiderman, ML Greenberg, BR Adelsberg, FP Siegal. Patients with AIDS and the AIDS related complex (ARC) often present with neutropenia. In an attempt to determine the etiology of this AIDS related neutropenia we assessed the proliferative capacity of the granulocyte-macrophage progenitor cell (CFU-GM) from the bone marrow (BM) of patients with the AIDS spectrum. |
| S19B | IMMUNOLOGIC ABNORMALITIES IN ASYMPTOMATIC HOMOSEXUAL MEN ARE RELATED TO HTLV-III/LAV EXPOSURE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S19B JKA Nicholson, JS McDougal, HW Jaffe, TJ Spira, H Raverkos, M Morgan. These results indicate that abnormal immune function in asymptomatic homosexual men is related to exposure to HTLV-III/LAV, resulting in a decrease in T helper cells and a "reactive" increase in T suppressor/cytotoxic cells. |
| S19C | DIFFERENTIAL IMPAIRMENT OF CYTOMEGALOVIRUS (CMV) AND CONCANAVALIN A (CON A) INDUCED LYMPHOCYTE INTERFERON (IFN) RELEASE AND CELL PROLIFERATION IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S19C Jay S Epstein, WR Frederick, AH Rook, H Masur, JY Djeu, GV Quinnan. We concluded that a viral antigen specific defect in lymphocyte IFN release exists in AIDS which is distinct from a non-antigen-specific defect in lymphocyte proliferation found in cases with OI. |
| S19D | INVOLVEMENT OF HTLV-III IN IMMUNOPATHOGENIC REACTIONS IN THYMUS AND SPLEEN OF PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S19D Drasko D Pekovic, JP Chausseau, N LaPointe, J Michaud, C Tsoukas, N Gilmore, H Goldman, JM Dupuy. These studies demonstrate an association of HTLV-III with immunopathogenic reactions in lymphatic organs of AIDS patients and suggest a primary etiologic role for the virus. |
| S19E | T CELL DIFFERENTIATION DEFECTS IN AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S19E Elinor M Levy, PH Black, K Mayer and JC Beldekas. People with AIDS have characteristic T cell subset imbalances and often have a decrease in the absolute number as well. Many questions remain about the pathogenesis of the disease. People with ARC may harbor the LAV/HTLV III virus for years without exhibiting a significant decrease in T cell number. The decline, however, once observed in AIDS seems to be irreversible. |
| S20A | NATURAL HISTORY OF HTLV-III SEROPOSITIVE PERSONS FROM AIDS RISK GROUPS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S20A JJ Goedert, SH Weiss, RJ Biggar, HM Ginzburg, RC Gallo, WA Blattner. Since 1981 we have prospectively followed 599 members of groups at high risk of AIDS. Sera were tested employing a highly specific and sensitive whole virus ELISA for HTLV-III antibodies (Ab). 5 cohorts were evaluated during 1983-84 for the proportion of HTLV-III Ab+ subjects who developed AIDS, Lesser AIDS (LAIDS, defined as oral candidiasis, herpes zoster, or idiopathic thrombocytopenia), or generalized lymphadenopathy (GL) |
| S20B | HETEROSEXUAL PROMISCUITY: AN EMERGING RISK FACTOR FOR HTLV-III DISEASE? Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S20B Robert R Redfield, PD Markham, SZ Salahuddin, MG Sarngaharan, DC Wright and RC Gallo. More than 30% of military personnel with HTLV-III disease (ARC and AIDS) lack evidence of defined risk factors. Common epidemilogical features in this no-risk factor group include: Black or Hispanic ethnic affiliation; greater than 100 heterosexul contacts over past 5 years; and employment of prostitutes. Clinical features and course of disease appear similar to that observed in defined high groups cases; however, the absence of Kaposi's sarcoma, the lack of active CMV disease and the low seropositivity for syphillis are distinctive. |
| S20C | ACQUIRED IMMUNODEFICIENCY SYNDROME IN HETEROSEXUAL MALES ASSOCIATED WITH SEXUAL CONTACTS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S20C Charles Rabkin, A Lekatsas, J Walker, R O'Donnell, N Garcia, P Thomas. Female sexual partners of intravenous drug user (IVDU), hemophiliac, bisexual, and Haitian males are at increased risk for acquired immunodeficiency syndrome (AIDS). To determine if heterosexual transmission to men occurs as well, we examined the sexual practices of 36 male AIDS cases without known risk factors who had been identified by New York City surveillance. |
| S20D | INCREASING TUBERCULOSIS INCIDENCE AND ITS RELATIONSHIP TO ACQUIRED IMMUNODEFICIENCY SYNDROME IN NEW YORK CITY Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S20D Rand L Stoneburner, A Kristal. Recent increases in tuberculosis (TB) incidence in New York City (NYC) may be related to the epidemic of acquired immunodeficiency syndrome (AIDS). We examined the NYC TB registry, AIDS surveillance data from 1981-84, narcotic-related deaths and 1980 U.S. census data to find evidence of this association. Of 2452 persons reported with AIDS, 133 also had TB. |
| S20E | A MODEL-BASED ESTIMATE OF THE AVERAGE INCUBATION AND LATENCY PERIOD FOR TRANSFUSION-ASSOCIATED AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S20E Dale N Lawrence, K-J Lui, DJ Bregman, TA Peterman, WM Morgan. Transfusion-associated AIDS cases offer a unique opportunity to estimate the mean incubation time (exposure to onset of symptoms) and the mean latency time (exposure to diagnosis), because the date of exposure is well defined. However, the traditional estimators, the simple averages of the observed incubation and latency times will underestimate the true means, especially in a situation in which the incidence of disease is increasing rapidly and the incubation time is long relative to the period the disease has been under study. |
| S21A | PSYCHOLOGICAL CHARACTERISTICS OF INDIVIDUALS WITH AIDS-RELATED CONCERNS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S21A C Richard Filson, CR Tartaglia, MA Tecco, H Fishman. Since the identification of Acquired Immunodeficiency Syndrome (AIDS) the largest at-risk group has remained homosexual and bisexual men. Previous reports describe significant anxiety, preoccupation with somatic concerns and dysphoria of varying severity, in subgroups including asymptomatic individuals and those with AIDS Related Complexes. One response to this psychological distress has been the frequenting of physicians in search of relief from these AIDS-related concerns. |
| S21B | THE PSYCHOSOCIAL EFFECTS OF AIDS-RELATED COMPLEX (ARC) ON YOUNG ADULT HEMOPHILIACS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S21B Gary G Bruno. Seven young adult male hemophiliacs with ARC were compared to a matched control group. The Millon Behavioral Health Inventory (MBHI) was administered as a pre-test to all subjects. After the pre-test was completed each patient was notified of his appropriate group, ARC or control. In the 6 months following, extensive medical testing occurred after which the MBHI was again administered. Results from 8 of the MBHI scales: chronic tension, recent stress, premorbid pessimism, future despair, social alienation, somatic anxiety, life-threat reaction, and emotional vulnerability, were analyzed using the Student's t test. |
| S21C | HETEROSEXUAL AIDS PATIENTS AND THEIR FAMILIES:IDENTIFICATION OF PSYCHOSOCIAL NEEDS AND PROVISION OF SUPPORT SERVICES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S21C Monnie Callan, R Klein, J Hewleit, J Vileno, P Kahl, G Friedland. The special problems of this heterosexual population of patients and families include inadequate income, housing and transportation, confidentiality of diagnosis of AIDS and drug abuse, fear of contagion, physical and emotional relationship between patients and family members, continued use of drugs, as well as depression, rejection, abandonment and issues of death and dying. These needs are inadequately addressed by the usual health care system, resulting in the establishment of a family oriented multidisciplinary AIDS team which addresses issues of fiscal entitlements, psychological needs of patients and families by individual counseling, patient and family support groups, bereavement group, hospital wide education program and patient information services. |
| S21D | PSYCHOLOGICAL AND NEUROPSYCHOLOGICAL FUNCTION IN AIDS SPECTRUM DISORDER PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S21D Susan Tross, J Holland, S Wetzler, JJ Sidtis, PW Price, BD Jordan. A longitudinal study is being conducted to characterize AIDS-associated dementias on neurological and neuropsychological parameters. Seventeen patients have been evaluated at time of diagnosis. Five of these were impaired on at least 3 out of 13 neuropsychological tests. |
| S21E | CHANGES IN SEXUAL BEHAVIOR OF GAY MEN: RELATIONSHIP TO PERCEIVED STRESS AND PSYCHOLOGICAL SYMPTOMATOLOGY Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S21E Jill G Joseph, CA Emmons, RC Kessler, D Ostrow, K O'Brien. Preliminary analyses indicate that 79% of the Detroit participants and 91% of the Chicago participants have changed some aspect of their behavior because of AIDS. Among these men, approximately 3/4 in both sites report that such changes are stressful on a day-to-day basis. Furthermore, 67%-81% of these men believe their behavior changes will fail to substantially reduce their risk of MDS. Psychological functioning as measured by Hopkins Symptom Checklist (SCL-58) appears most symptomatic in those men with higher levels of stress and who doubt the value of their behavioral changes. Young participants (30 years of age) were at particularly high risk. |
| S22A | AIDS IN HAITI. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S22A J Pape, B Liautaud, F Thomas, M Boncy, J Dehovitz, W Johnson. We studied 177 previously healthy Haitians with AIDS between June 1979 and September 1984. Eleven percent of the 27 Kaposi's sarcoma patients and 23% of the 150 patients with opportunistic infections were female. Risk factors were identified in 48% of the 85 patients prospectively studied since July 1983. In contrast, only 20% of our initial 92 patients had risk factors identified. Risk factors included male bisexuality 32%, blood transfusions 14% 0/63 males; 9/22 females) and either IV drug abuse or spouse with AIDS, 2%. |
| S22B | DETECTION OF ANTIBODIES TO AIDS-ASSOCIATED RETROVIRUSES (ARV) IN THE DOMINICAN REPUBLIC. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S22B R Ellen Koenig, J Pittaluga, M Bogart, M Castro, and JA Levy. There are Haitian migrant workers in the Dominican Republic, and a sampling of these workers was also conducted. In these studies, 4 out of 45 individuals tested were positive for ARV. There have been no documented cases of AIDS in individuals in the Dominican Republic who have solely lived in that country. These results indicate that the virus most likely responsible for AIDS is present in the Dominican Republic, but has not spread widely in the general population as it has in Haiti. They raise in interesting epidemiologic question as to why there is a greater prevalence of ARV in Haiti than in the Dominican Republic. |
| S22C | SEROEPIDEMIOLOGICAL STUDIES OF HTLV-III ANTIBODY PREVALENCE AMONG SELECTED GROUPS OF HETEROSEXUAL AFRICANS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S22C Nathan Clumeck, M Robert-Guroff, P Van De Perre, A Jennings, P Demol, RC Gallo. Antibodies against HTLV-III were determined by enzyme linked immunosorbent solid assay (ELISA) and Western Blot technics in African patients with AIDS (n=53) or Aids-related complex (ARC) (n=33), in healthy un selected Rwandese blood donors (n=27), in African female prostitutes (n=70) and their customers (n=25), and in 45 healthy Zairian and Rwandese controls matched for age, sex and annual income. |
| S22D | SEROEPIDEMIOLOGY OF HTLV-III IN EASTERN ZAIRE AND KENYA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S22D RJ Biggar, B Johnson, P Gigase, P Sarin. These studies suggest that either the natural history of HTLV-Ill infection is different in Africa than the US or that serum reactivity is being provoked by an agent similar but not identical to HTLV-III. Although Western blot analyses on a selected subset of sera were consistent with specific reactivity against HTLV-III, antibody could have been provoked by a similar but slightly different virus. Viral isolation for comparison by molecular analysis will be needed. |
| S22E | HTLV-III SEROPREVALENCE AMONG HOSPITAL WORKERS IN KINSHASA, ZAIRE Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S22E Bela M Kapita, JM Mann, H Francis, K Ruti, T Quinn, JW Curran. In October 1984, a seroprevalence study was conducted among employees of the Mama Yemo Hospital in Kinshasa, Zaire. This 2,000-bed hospital provides medical care for approximately 60% of AIDS patients currently reported in Kinshasa. Two-thousand four-hundred of the 2,500 hospital personnel (96%) participated in the study. Under the auspices of the Project SIDA, a collaborative international project studying AIDS in Zaire, each employee was interviewed regarding basic demographic information, exposure to selected community risk factors, work history at Mama Yemo Hospital, work history in medical settings, level of contact with patients and extent of occupational exposure to blood. |
| S23A | AIDS HEALTH EDUCATION RISK REDUCTION STRATEGIES: IMPLEMENTATION AND EVALUATION EFFORTS IN 9 CITIES Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S23A Michael Gorman, R Needle, JT Jones, MW Kreuter. Since AIDS was first reported in 1981 numerous educational efforts have been undertaken by local health departments and community organizations. To date, little documentation exists as to the nature, scope, quality and validity or effectiveness of these activities. For the purposes of establishing a baseline of information, identifying models and criteria for program development and training, and establishing parameters for evaluating program results, CDC investigators have collected and analyzed data describing current AIDS related organizations and coalitions in nine cities with high incidence of AIDS (New York City, Newark, Washington, D.C., Atlanta, Chicago, Houston, San Francisco and Los Angeles). |
| S23B | USING DETAILED SURVEILLANCE DATA ON AIDS IN CONNECTICUT TO ENHANCE HEALTH EDUCATION PROGRAMS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S23B William Sabella and A Novick. The programs can be specialized for age, race, sex, and perhaps even for bisexual vs. homosexual men. We shall present detailed illustrations of the patterns of incidence of AIDS in Connecticut and outline the ways in which educational programs may be focussed, thus conserving limited local resources while sharpening impact. |
| S23C | THE ECONOMIC IMPACT OF (AIDS) IN THE UNITED STATES Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S23C Ann M. Hardy, Katherine J Rausch, James W Curran. From tables published by the Social Security Administration, the cost of output lost due to disability and premature death was over $650 million. Thus, to date, the AIDS epidemic has cost more than $1.5 billion. This analysis emphasizes the importance of AIDS as a public health problem and underscores the need for developing and implementing effective disease prevention strategies. |
| S23D | THE COST OF TREATMENT OF AIDS PATIENTS IN A COUNTY HOSPITAL. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S23D Anne Scitovsky, Peter Arno and Philip Lee. This study provides data on costs of treatment of AIDS patients treated in San Francisco General Hospital during calendar year 1984. We will estimate costs of treatment per admission of all AIDS patients admitted during calendar year 1984 by type of disorder (pneumocystis pneumonia, cryptococcus meningitis, CNS toxoplasmosis, opportunistic infections, admission for evaluation or treatment of AIDS related malignancies and all other diagnoses); by type of treatment setting in either the special AIDS unit or one of the general wards, and by type of hospital service and inpatient professional service (room and board, lab tests, x-rays). |
| S24A | EXPERIMENTAL INFECTION OF CHIMPANZEES WITH HTLV-III/LAV AS A POTENTIAL MODEL FOR AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24A Patricia N Fultz, DP Francis, JR Broderson, HM McClure, CR McGrath, JP Getchell. After reaching a peak; antibody titers remained high. Percentages of T-helper and T-suppressor cells fluctuated, but no significant decreases in T-helper cells have occurred, nor has there been an impairment of PHA blastogenesis. There have been no clinical signs of disease in any of the infected chimpanzees. |
| S24B | RETROVIRUS HTLV-3 IDENTIFIED IN THE BRAINS OF PATIENTS WITH AIDS ENCEPHALOPATHY BY TRANSMISSION TO CHIMPANZEES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24B DC Gajdusek, CJ Gibbs, Jr., LG Epstein, DM Asher, P Rodgers-Johnson, HL Amyx. A progressive encephalopathy occurs frequently in adult, juvenile and infant AIDS patients. Opportunistic infections and pathologic brain changes do not explain the clinical encephalopathy. Identification of retrovirus HTLV-3/LAV as the etiologic agent of AIDS suggests primary retrovirus infection of the brain may cause AIDS encephalopathy. We attempted transmission of this encephalopathy to chimpanzees. |
| S24C | ATTEMPTED INFECTIONS OF RODENTS AND PRIMATES AND THEIR LYMPHOCYTES WITH HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24C Gerald V. Quinnan, MA Wells, DB Burlington, SC Kiley, PJ Snoy, JS Epstein. HTLV-III inoculated mice developed persistent antibody responses by ELISA, failed to gain weight, expressed abnormal responses to T cell mitogens, and attempts at virus isolation are in progress; rats had transient antibody responses; rhesus monkeys had persistent antibody responses, two of three had inverted T4/T8 ratios, and lymphocytes obtained at 30 and 60 days, but not 90 or 120 days PI expressed antigens and reverse transcriptase after T cell mitogen induction; marmoset antibody responses were transient, antigen induction attempts were positive through 60-120 days PI, and one died with lymphopenia and lymphoid tissue abnormalities. Further studies are warranted to evaluate possible persistent HTLV-III infection and disease in mice and marmosets. |
| S24D | INACTIVATION OF LYMPHADENOPATHY ASSOCIATED VIRUS (LAV) BY CHEMICAL AND PHYSICAL AGENTS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24D Françoise Barre, B Spire, D Dormont, L Montagnier & JC Chermann. The human retrovirus, named LAV or HTLV-III by others, is strongly linked to the cause of AIDS. The effect of several commonly used chemical disinfectants on LAV has been studied using the reverse transcriptase (RT) as an indicator of viral inactivation and has been confirmed by viral infectivity assay. The virus is inactivated in the first 5 min by a treatment with 0.2% sodium hypochloride. |
| S24E | PHOTOCHEMICAL INACTIVATION OF HTLV-III Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24E CV Hanson, JC Richards, DA Brusini, S Lambert, RA Nelson, and AJ Bodner. The advantages of the psoralen photoinactivation procedure permit practical use of treatments in vast excess of the minimum required for detectable inactivation, thus achieving a large safety margin which cannot be attained with conventional techniques. |
| S24F | USE OF QUANTITATIVE INFECTIVITY ASSAYS FOR HTLV-III TO INVESTIGATE STERILIZATION PROCESS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24F AM Prince, B Horowitz, H Dichtelmueller, W Stephan, R Gallo. Inoculation of H-9 cells with serial dilutions of HTLV-III, followed by reverse transcriptase assays on supernatants after 14 days incubation, provides a simple means for quantitation of the infectivity of this virus. |
| S24G | STABILIZATION AND INACTIVATION OF HTLV-III Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24G Gerald V Quinnan, MA Wells, S Daniel, SC Ktley, RE Mayner, C Marcus-Sekura. Preparations inactivated by BPL, triton x-100, or ether retained antigenicity in enzyme immunoassay, whereas formalin-treated preparations did not. Some procedures applied to biologics such as clotting factors, immunoglobulins, and hepatitis B vaccine appear to be effective in inactivating HTLV-III. |
| S24H | INACTIVATION OF THE HTLV-III/LAV VIRUS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24H Linda S Martin, JS McDougal, S Loskoski, SP Cort, BL Evatt, M Mozen, CM Heldebrant. HTLV-III/LAV titers were determined after treatment of HTLV-III/LAV with chemical and physical inactivators by a microculture infectivity assay (McDougal et al., J. Immunol. Methods, 76:171, 1985.) |
| S24I | RECOVERY OF INFECTIOUS AIDS-ASSOCIATED RETROVIRUS (ARV) FROM LYOPHILIZED FACTOR VIII PRODUCTS AFTER ADDITION OF VIRUS TO PLASMA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S24I Jay A Levy, G Mitra, and M Mozen. We have previously reported that mouse type C retroviruses can survive the procedures used for the preparation of Factor VIII concentrates and are present in infectious form in the lyophilized product. They can only be eliminated by heating (68°C) for more than 48 hours. The safety and efficacy of Factor VIII are not affected under these conditions. We have analyzed the ability of the type D AIDS-associated retrovirus (ARV) to withstand these procedures. |
| S25A | OUTBREAK OF LAS IN A GROUP OF DRUG ADDICTS: CORRELATION WITH THE INTRODUCTION OF HTLV III IN THE GROUP. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S25A A Lazzarin, M Galli, F Aiuti, C Negri, G Poli, M Moroni. An outbreak of lymphadenopathy syndrome (LAS) has been recorded since March 1983 in intravenous drug addicts attending the Drug Addicts Assistance Center of L. Sacco Hospital, Milan. A retrospective survey revealed that the onset of symptoms in the first case had appeared in April 1982. The highest incidence of new cases was recorded in September-November 1983. |
| S25B | AIDS IN THE UNITED KINGDOM: EPIDEMIOLOGY AND BEHAVIOUR STUDIES IN HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S25B Mariah McEvoy, TJ McManus. Although the first report of AIDS in the United Kingdom (UK) appeared in 1981, a case with onset of symptoms in 1979 was later reported retrospectively. During 1982 and 1983 there was a slow increase in the number of cases but by December 1984 there were 102 cases and the epidemic curve showed an exponential rise. Intravenous drug abuse has not yet emerged as a risk factor ill the U.K. and there are 6 female cases who had contact with Central Africa. |
| S25C | IMMUNOLOGICAL AND VIROLOGICAL STUDIES IN AIDS,RISK GROUPS IN HUNGARY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S25C SR Hollan, George Fust, K Nagy, A Horvath, E Ujhelyi, L Varga. So far Hungary could be considered as low risk area for AIDS as no patient with AIDS or AIDS-related complex had been found till December, 1984. Our studies were aimed to investigate the seroepidemiological status of AIDS risk groups by anti-HTLV-III measurements and to study as to whether immunological alterations found in high risk areas of AIDS can be observed in the same groups of population in our country as well. 32 patients with mild hemophilia, 36 with severe hemophilia, and 39 homosexual males were investigated in parallel with 37 heterosexual blood donors as controls. |
| S25D | HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE III (HTLV-III) ANTIBODY POSITIVITY IN CANADIAN HEMOPHILIACS, HOMOSEXUALS AND CONTROLS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S25D Michael V O'Shaughnessy, JM Weber, C Tsoukas, N Gilmore, J Boyko, S Read. These data confirm that HTLV-III antibody positivity is strongly associated with AIDS and AIDS related symptoms. However, further study is required to explore the finding that only 60% (45/75) of Vancouver homosexual subjects with persistent unexplained generalized lymphadenopathy are HTLV-III antibody positive. |
| S25E | THE EVOLVING EPIDEMIOLOGY OF HTLV-III INFECTION IN AUSTRALIA: RESULTS OF A SEROLOGICAL SURVEY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S25E Ian D Gust, HG Williamson, RC Pringle, NI Lehmann, JF O'Duffy. Recently collected and stored sera from members of groups at increased risk of acquiring AIDS were tested for evidence of infection with HTLV-III by ELISA. All positive sera were then checked for specificity by RIP and/or Western Blot. |
| S26A | EDUCATING PARENTERAL DRUG USERS ABOUT AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26A Harold M Ginzburg, MR Rose, SH Weiss. Most of those at apparent increased risk for AIDS are receiving appropriate attention regarding education about and prevention of the disease. Such groups as homosexual males, recent Haitian immigrants, and hemophilia patients are generally responsive to public health education and are supported by special interest groups. However, parenteral drug users, the second most at-risk group for AIDS, are typically less responsive to public health information and do not have their own advocacy organizations. Thus, a concerted effort must be made to reach these individuals, assess their awareness of and knowledge about the disease, and effectively alert them to the dangers and risks of AIDS. |
| S26B | ADOPTION OF MODIFICATIONS IN SEXUAL BEHAVIOR AMONG ASYMPTANATIC HOMOSEXUAL MEN Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26B Karolynn Siegel, DA Hirsch, GH Christ. At the present time the spread of AIDS can best be limited through the adoption of modifications in risky practices by at-risk-groups. While professional and gay organizations have disseminated sexual guidelines, little data exists on the extent to which they have been adopted. Data were analyzed from the first 54 asymptomatic homosexual males accrued as controls in a study of modifications in sexual practices. Subjects were asked whether they had adopted each of 5 modifications since learning of the AIDS epidemic. The data revealed 83% had fewer different sexual partners; 74% had fewer anonymous partners; 30% had increased their use of condoms; 28% were more often insisting that partners use condoms; and 38% had reduced their use of drugs with sex. |
| S26C | STABILITY AND CHANGE IN GAY SEX: THE CASE OF SAN FRANCISCO Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26C Leon McKusick, T Coates, R Stahl, G Saika, M Conant, J Wiley. Sexual behavior, relationship patterns, health, and awareness of AIDS were assessed in a sample of 454 subjects in a continuing study of gay men in San Francisco, under the NIMH. Baseline data from four subgroups were gathered in November 1983 (and retrospectively to November 1982). Additional waves of data were taken from the same subjects in May and November 1984. By May 1984, it was evident that the overall level of sexual activity had decreased significantly in all subgroups over November 1983, in terms of numbers of partners as well as specific high risk activities. |
| S26D | SEXUAL BEHAVIOR CHANGE AND PERSISTENCE IN HOMOSEXUAL MEN Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26D David G Ostrow, CA Emmons, NL Altman; JG Joseph, JP Phair, J Chmiel. These findings indicate that changes in sexual behavior aimed at reducing risk of AIDS is occurring in the gay male population. Maintenance of these changes and extension to individuals still at risk may require supportive counselling and ongoing educational exposure. |
| S26E | IMPLICATIONS OF HTLV-III ANTIBODY TESTING FOR GAY MEN Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26E J Allen McCutchan, E Fantino, D Case, S Stolarz-Fantino, P Spechko. After 149 gay volunteers from a longitudinal study of AIDS heard a detailed lecture on AIDS, they answered questions about their attitudes towards obtaining HTLV-III antibody test results, how they would modify their behavior depending on the outcome, their personal risk of AIDS, and their attitudes towards information about hypothetical favorable and unfavorable events unrelated to AIDS. More than 75%of volunteers wanted HTLV-III AB results even if the test could be wrong, they could do nothing more to reduce risk, or had to wait up to 6 months for results. |
| S26F | CONTROLLING THE SPREADOF AIDS IN HETEROSEXUALS IN SAN FRANCISCO Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S26F G Slutkin, S Gove, K Rauch, R Anderson, M Silverman, and Dean F Echenberg. Contact tracing maybe applicable for NRG because of low prevalence of infection and smaller number of contacts. The comparative efficacy of RRE for the predominantly uninfected NRG vs. education of individuals found to be infected in limiting spread of AIDS in the HT community is unknown. The consequences of knowing one is infected should be studied as confidential contact tracing and voluntary screening are considered for various groups. |
| S27A | RIBAVIRIN SUPPRESSES REPLICATION OF LYMPHADENOPATHY-ASSOCIATED VIRUS IN CULTURES OF HUMAN ADULT T LYMPHOCYTES Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S27A JB McCormick, Jane P Getchell, S Mitchell, DR Hicks, J Heath. Lymphadenopathy-associated virus (LAV) is one prototype isolate of the virus proposed as the cause of acquired immunodeficiency syndrome (AIDS). The isolation of this virus has permitted the systematic search for prevention of and therapeutic intervention for AIDS in ways not previously possible. We have examined one potential therapeutic agent, ribavirin, which has been used extensively for the treatment of other virus infections of humans. |
| S27B | EFFECTS OF RIBAVIRIN ON IITLV-III VIRAL PROTEIN EXPRESSION Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S27B C Crumpacker, MF Mclane, J Allan and M Essex. Viral protein expression in H9-IIIB cells appear to be inhibited by RBV (10ug/ml) after 24 hours of incubation and suppressed after 96 hours. In Molt 3-III cells, HTLV-III proteins are partially suppressed after 24 hours but are strongly expressed after 4 days of incubation with RBV (10ug/ml). Cell cytotoxicity assays with EBV indicate that cells remain viable at 4 days with RBV (100ug/ml). Low doses of RBV can inhibit expression of HTLV-III specific proteins in the absence of, severe cellular toxicity. |
| S27C | ANSAMYCIN INHIBITS REPLICATION AND INFECTIVITY OF HTLV III/LAV. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S27C R Anand. This drug has shown inhibitory effect both on the infectivity and on the replication of the virus. LM 427 exerts marked inhibitory effect on HTLV-III/LAV at nontoxic concentrations which appear to be clinically attainable in humans. The sites of action of ansamycin LM 427 in the viral life-cycle and its usefulness as a therapeutic agent in pre-AIDS patients will be elaborated. |
| S27D | MECHANISM OF INHIBITION OF LAV REPLICATION IN PATIENTS TREATED WITH ANTIMONIOTUNGSTATE (HPA 2 3) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S27D Jean-Claude Chermann, B Spire, F Barre, L Montagnier & D Dormont. The antimoniotungstate (HPA2 3) is a mineral condensed ion with a crypticstructure. It is a potent inhibitor of retroviral induced leukemia or tumors in mice. One of the known mechanisms of its action is the competitive inhibition of the viral reverse transcriptase. This compound is also active in mice infected with Scrapie and has been used in human to attempt treatment of Creutzfeld-Jakob disease. Promising results have been observed by our group in some AIDS or ARC patients treated with this compound. |
| W-1 | SCREENING TESTS FOR BLOOD DONORS PRESUMED TO HAVE TRANSMITTED AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-1 J Steven Mcdougal, HW Jaffe, CD Cabradilla, MG Sargadharan, JKA Nicholson, VS Kalyanaraman, CA Shable, B Kilbourne, BL Evatt, RC Gallo, JW Curran. We investigated 18 sets of blood donors 12-50 months after they donated blood to a recipient who subsequently developed AIDS. Within each donor set, only one donor suspected of having transmitted the disease (i.e. they were members of an AIDS risk group). The other donors were not risk-group members and served as a control group. |
| W-2 | EFFICACY OF VOLUNTARY SELF-DEFERRAL OF CONORS AT HIGH RISK OF AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-2 Alfred J Frindon, MD Since STS and HBsAg positivity are in part markers of sexual promiscuity, these data suggest that other sexually transmitted diseases, such as AIDS, particularly if associated with men aged 21-30, should also be significantly reduced in our donor population. We conclude that the risk of transfusion-associated AIDS has been reduced from what it would have been without such a deferral policy. |
| W-3 | AIDS IN A THALASSAAIC PATIENT TRANSFUSED WITH FROZEN THAWED WASHED RED CELLS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-3 PJ Giardina, AN Akbar, SZ Salahuddin, H Murray, R Gallo, MW Hilgartner. All other cultures and serology were negative. Serum was pos. for HTLV-III AB. Serial lymphocyte studies revealed decreasing T4/T8 ratios, decreased activity and absent antigen induced proliferation. These results indicate that AIDS can develop in a Thalassemic patient receiving deglycerolized red cell transfusions. |
| W-4 | EVIDENCE FOR TRANSMISSION OF HTLV-III TO EUROPEAN HAEMOPHILIACS VIA IMPORTED FACTOR VIII CONCENTRATE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-4 Mads Melbye, KS Froebel, R Madhok, RJ Biggar, P Sarin, S Stenbjerg. 77 Scottish haemophiliacs and 22 Danish haemophiliacs were serologically analyzed for antibodies against the human T-cell leukemia virus (HTLV-III). Since1979 Scottish patients have been treated mostly with factor concentrate entirely produced in Scotland, whereas all but 2 Danish patients have regularly received both commercially and locally produced concentrate. |
| W-5 | LYMPHADENOPATHY SYNDROME IN TWO THALASSEMIC CHILDREN AFTER LAV CONTAMINATED TRINSFUSION Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-5 Etienne Vilmer, B Girot, C Rouziqux, S Chamaret, L Montagnier. Thalassemic major patients require monthly packed red blood cells transfusions prepared by freezing and thawing technique or the filtration technique. A blood donor had given his blood during the year preceding the onset of an AIDS, and anti bodies to the major core protein p25 and pl8 bad been detected in his serum as assessed by radio-immunoprecipitation assay (RIPA). Six to eight weeks after the transfusion both thalassemic patients presented a lymphadenopathy syndrome. |
| W-6 | DELAYED HYPERSENSITIVITY IN A GROUP OF HEMOPHILIACS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-6 Doreen B Brettler, JL Sullivan, AD Forsberg, PH Levine. There were no significant differences between age, absolute suppressor cells, or helper/suppressor ratio when comparing hemophilic skin test responders and nonresponders. It does appear that there is a correlation between DTH and factor usaged in this population. |
| W-7 | CARDIAC FINDINGS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-7 Ira L Weg, H Noveck, M Saunders, S Zoneraich. Pericardial effusion was found in 2 of the 9 abnormal post-mortems, but no patients had pericardial tamponade. Cardiac findings are common in AIDS patients. Echocardiography is the most sensitive test to detect these abnorma1ities pre-mortem. |
| W-8 | LYMPHADENOPATHY AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-8 W Abe Andes, KM Wulff, RD deShazo, K Ohene-Frempong, CB Daul, D Mercer. These studies emphasize the similarities between patients with hemophilia or with other risks for AIDS who develop lymphadenopathy. With the growing recognition of variant HTLV-III genomes, efforts to optimally prescribe blood products and study their recipients should continue. |
| W-9 | HTLV-III ANTIBODIES AND DEVELOPMENT OF AIDS IN HOMOSEXUAL MEN PRESENTING WITH IMMUNE THROMBOCYTOPENIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-9 Donald I Abrams, DD Kiprov, JJ Goedert, MG Sarngadharan, RC Gallo and PA Volberding. This confirms the belief that ITP in homosexual men is an AIDS-related condition. Twenty pts were treated with steroids. Serial determination. of H:S ratios during prednisone therapy did not significantly alter the ratio from baseline levels. Only 2 pts achieved a sustained remission. 8 of 23 splenectomized pts continue with normal platelet counts. One pt treated with steroids followed by splenectomy developed Pneumocystis pneumonia 31 mos. after the initial ITP dx. A second developed a small bowel lymphoma after 36 mos. |
| W-10 | LYMPHADENOPATHY-ASSOCIATED VIRUS (LAV) ANTIBODY IN HOUSEHOLD CONTACTS AND SEXUAL PARTNERS OF PERSON WITH HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-10 Janine Jason, JS McDougal, G Dixon, DN Lawrence, MS Kennedy, M Hilgartner. We conclude that risk of LAV transmission may exist for sexual contacts of hemophiliacs with AIDS/ARC. We have not demonstrated if there is a risk for nonsexual contacts or if risk is greater for contacts of AIDS/ARC patients than for healthy Ab+ hemophiliacs. |
| W-11 | ANTIBODIES TO HTLV-III/LAV IN FRENCH HEMOPHILIACS RECEIVING VARIOUS CLOTTING FRACTIONS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-11 D Mathez, Y Sultan, P Lebon, Jacques Leibowitch. Sera from 40 A and 4 B hemophiliacs were assayed for antibodies to HTLV-III-associated cytoplasmic antigens (Lancet. 1984 Aug 25;2(8400):460). Sera-positivity was found in 27 (60%). For 23/27 retrospective ab-negative sera allowed an approximation on the data of sera-conversion. Trimestrial prevalence of ab-positivity has been increasing quasi-linearly since the winter of 1982. Nature, quantities, origins of the transfused material could be determined in 10 ab-positives: 8 had received fractions prepared from plasmas obtained in France (CNTS). |
| W-12 | PREVALENCE AND SEROCONVERSION RATE OF HUMAN T LYMPHOTROPIC RETROVIRUS (HTLV-III) ANTIBODY IN PATIENTS WITH HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-12 Margaret V Ragni, GE Tegtmeier, C Handwerk-Leber, JH Lewis, WL Bayer, JA Spero. These results indicate a progressive increase in HTLV-III antibody prevalence between 1981 and 1984 and in seroconversion after 1982 in the hemophiliac population, occurring primarily in those exposed to factor VIII concentrate. |
| W-13 | LYMPHADENOPATHY-ASSOCIATED VIRUS (LAV) ANTIBODY IN PERSONS WITH HEMOPHILIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-13 Janine Jason, JS McDougal, RC Holman, SF Stein, DN Lawrence, JKA Nicholson. We conclude that both Factor VIII and Factor IX concentrates may transmit LAV. For FVIII, LAV seropositivity is associated with altered immune tests. |
| W-14 | INCIDENCE OF ANTIBODIES TO HTLV III IN AIDS, HEMOPHILIA AND MULTIPLY TRANSFUSED INDIVIDUALS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-14 C Tsoukas, P Gold, M O'Shaughnessy, JM Weber. An ELISA screening assay and a confirmatory Western blotting test were used to detect HTLV III antibodies in the following Canadian groups: 7 patients with either classical, African or epidemic Kaposi's sarcoma, 10 with AIDS and opportunistic infections, 84 hemophiliacs receiving antihemophilic factor infusions, 9 family members of 5 hemophiliacs with AIDS related complex as well as those having received multiple blood transfusions (20 Thalassemics, 20 dialysis and 23 carcinoma patients). |
| W-15 | ANTIBODIES TO HTLV-III IN ASYMPTOMATIC HEMOPHILIACS AND IN HEMOPLILIAC AIDS CASES Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-15 Lynn W Kitchen, F Barin, JL Sullivan, DB Brettler, PH Levine, M Essex. Fifty hemophiliacs from the New England Area Comprehensive Hemophilia Center in Worchester, Massachusetts were tested for antibody to HTLV-III by IMI and RIP-SDS/PAGE. All were asymptomatic at the time of serum collection, except for a single patient who had clinical AIDS. Two more individuals developed AIDS within 3-6 months. Of 50 samples. 33 tested positive (32 with hemophilia A and 1 with hemophilia B) including the three AIDS patients. |
| W-16 | HIGH PREVALENCE OF ANTIBODIES TO AIDS-ASSOCIATED RETROVIRUS (ARV) IN HEMOPHILIACS TREATED WITH FACTOR VIII AND IX CONCENTRATES AND RECOVERY OF VIRUS FROM ONE PATIENT. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-16 Marion A Koerper, LS Kaminsky and JA Levy. Our results suggest that patients treated with either Factor VIII or IX concentrates receive sufficient exposure to infectious ARV or to viral antigens to produce an immunologic response. In at least one San Francisco hemophiliac, infectious virus was probably transmitted via the concentrate. |
| W-17 | CRYPTOCOCCAL MENINGITIS (CM) COMPLICATING AIDS: ANALYSIS OF 22 CASES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-17 Stephen E Follansbee, F Busch. Amphotericin B (0.3 - 0.5 mg/kg/d) was given to 19 patients for 6 weeks or more. Five-fluorocytosine was given to all patients initially but was often poorly tolerated. After 6 weeks of therapy, 1/19 patients had sterile CSF, negative India ink stain, and negative cryptococcal antigen. The remainder had sterile CSF, but India ink preparation was positive in 14/19, and cryptococcal antigen was detected in 18/19 follow-up CSF specimens. Relapses were confirmed in 3 patients before death, one while taking 400 mg of ketoconazole per day. Eight-six percent of patients died within 6 months of diagnosis of CM. |
| W-18 | CRYPTOCOCCOSIS IN PATIENTS WITH AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-18 Joseph A Kovacs, AA Kovacs, M Polis, C Wright, E Gelmann, H Masur. Patients received amphotericin B alone or with flucytosine. Neither regimen was very effective, using standard courses. Of 10 patients improved following therapy, 4 relapsed clinically, 2 relapsed by autopsy; 2 died without autopsy, and 2 are alive off therapy. Thirteen patients were clinical failures; 3 are on therapy. Response did not correlate with total amphotericin B dosage or the use of flucytosine. Flucytosine was discontinued in 6/18 patients due to leukopenia. Cryotococcus was found histopathologically in 13/14 autopsies. Cryptococcosis in AIDS is characterized by meningitis or disseminate disease; routine CSF parameters are frequently normal. Low dose maintenance amphotericin B or other drug regimens need evaluation. |
| W-19 | CRYPTOCOCCAL DISEASE IN AIDS PATIENTS: DIAGNOSTIC FEATURES AND OUTCOME OF TREATMENT. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-19 Abigail Zuger, E Louie, RS Holzman, JJ Rahal, MS Simberkoff. However we found no significant differences between those who relapsed and those who did not in presentation, CSF exam, degree of dissemination or response to treatment. Our data suggest that maintenance therapy with Am may be needed to prevent relapse in patients with AIDS. |
| W-20 | POORLY ENCAPSULATED CRYPTOCOCCUS NEOFORMANS FROM AIDS PATIENTS: MORPHOLOGIC, CULTURAL, AND PATHOGENIC CORRELATES. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-20 Edward J Bottone, BE Johansson, A Szporn, M Toma, M Poon, GP Wormser. C. neoformans recovered from 10 AIDS patients were studied in conjunction with three non-AIDS isolates. On primary culture 9/10 AIDS isolates grew as nonmucoid colonies resembling those produced by "diphtheroids". One isolate formed moist colonies. The three non-AIDS isolates produced highly mucoid colonies. India ink mounts of primary cultures of the 10 AIDS isolates showed markedly smaller capsules than the 3 non-AIDS strains. India ink preparations of 3 fresh spinal fluid samples from AIDS patients in which capsule sizes were systematically determined showed a preponderance of poorly encapsulated cells (2.5-7.5 µm). |
| W-21 | THERAPY OF PEDIATRIC ACQUIRED IMMUNE DEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-21 James Oleske, M Boland, M Zabala, R Bobila, F Desposito, A Minnefore. Of 22 patients treated with IV gammaglobulin 3 have died while of 12 patients not treated 10 have died. Pediatric AIDS/ARC is a severe disease but vigorous, supportive therapy can make an impact on morbidity and mortality. The data showing clinical improvement in pediatric AIDS cases with IV gammaglobulin therapy should encourage similar control studies in the larger numbers of adult AIDS/ARC patients. |
| W-22 | NEUTROPHIL-ASSOCIATED ANTIBODIES AND GRANULOCYTOPENIA IN THE SULFONAMIDE REACTION IN AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-22 Eric Outwater and JA McCutchan. Adverse reactions to sulfonamides (e.g. cotrimoxazole) consisting of fever, rash, leukopenia, and more rarely thrombocytopenia, are common in AIDS and interfere with therapy for pneumocystis and toxoplasmal infections. Review of 14 patients who developed this reaction (11 On cotrimoxazole and 3 on sulfadiazine) revealed that granulocytopenia and low grade eosinophilia, but not lymphopenia, were common features. |
| W-23 | A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR QUANTIFICATIN OF PENTAMIDINE IN SERUM. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-23 Charlotte M Dickinson, TR Navin, FC Churchill. Our method, which involves liquid ion-exchange extraction, high-performance liquid chromatographic analysis with a microbore column, and hexamidine as an internal standard, measured pentamidine concentrations of 10 ng/ml with good precision. Pentamidine serum concentrations were analyzed in dogs at timed intervals after single,15-minute intravenous injections of 4 mg/kg pentamidine isethionate. Pentamidine concentrations, which were between 40 and 150 ng/ml 1 hour after the injection, fell to 10-30 ng/mi at 4 hours. The half-time for drug elimination from serum was approximately 75 minutes. |
| W-24 | PERSISTENCE OF PNEUMOCYSTIS CARINII PNEUMONIA IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-24 LJ Delorenzo, GP Maguire, GP Wormser, M Davidian, and DJ Stone. Those episodes with positive follow-up biopsies could not be distinguished from those with negative biopsies when standard clinical parameters (fever response, arterial blood gas, radiographic characteristics) were compared retrospectively. Persistence of PCP after conventional treatment may be an important factor in recurrences of this infection in AIDS patients. |
| W-25 | TREATMENT OF FIRST EPISODE PNEUMONIA (PCP) IN AIDS PATIENTS WITH DAPSONE AND TRIMETHOPRIM (DS/TMP). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-25 Gifford S Leoung, J Mills, W Hughes, P Hopewell, C Wofsy. Existing therapy for PCP In AIDS suffers from high Incidence of toxicity and Is effective In only 60-70% of patients. Hughes has shown that dapsone alone or with trimethoprim Is effective In the treatment of murine PCP. On 1 November 1984 we began a study using dapsone 100 mg/d and trimethoprim 20 mg/kg/d divided q6h (DS/TMP) for 3 weeks as treatment for first-episode PCP In AIDS patients. In 4 weeks, 4 patients have been enrolled. All 4 patients have responded well with a decrease In cough and shortness of breath and improvement In both clinical exam and chest x-ray findings. |
| W-26 | THE NATURAL HISTORY OF TREATED PNEUMOCYSTIS CARINII PNEUMONIA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-26 Mario J Saldana, JM Mones, MA Fischl, GM Dickinson, and SA Oldham. Pattern II consisted of 13 patients who survived the first week of disease but died within 2 months of diagnosis. Lack of response to therapy was probably the result of concommitant infections (CMV, TB, fungi, etc.) together with the effects of oxygen toxicity. In Pattern III, composed of 37 patients, a favorable response to therapy was noted initially; however, the patients died between 2 months and 2 years of the original diagnosis. Only 2 of these 37 patients had PCP at necropsy, probably due to reinfection. Death was the result of other infections or tumors commonly seen in patients with AIDS. |
| W-27 | DEVELOPMENTAL THERAPEUTICS FOR PNEUMOCYSTIS CARINII PNEUMONIA (PCP). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-27 Walter T Hughes. A decade ago we used the corticosteroid-antibiotic primed animal model for PCP to identify trimethoprim (TMP) sulfamethoxazole (SMZ) as an effective therapeutic and prophylactic drug for PCP. Subsequent clinical studies showed excellent correlation with the animal model. Because of adverse reactions to TMP-SMZ in AIDS patients, we have now undertaken studies to develop new agents for PCP. The experimental design is based on the premise that dexamethasone-tetracycline given for 6 weeks will provoke PCP in the rat. |
| W-28 | PENTAMIDINE-ASSOCIATED HYPOTENSION BY ROUTE OF ADMINISTRATION Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-28 Charles G Hemlick, JK Green. To investigate this issue, we reviewed the charts of 167 patients from 15 hospitals in New York City who received pentamidine in 1984. Eighty-two patients received pentamidine by IM injection (IM group) and 66 by slow IV infusion (IV group). Nineteen patients who received both IM and IV pentamidine are not included in this analysis. Sixty-four patients in the IM group (78.0%) and 44 patients in the IV group (66.7%) experienced at least one episode of hypotension. The temporal relationship between pentamidine administration and hypotension could be determined for 46 patients. Of these, 10 of 25 patients in the IM group (40.0%) and 11 of 21 patients in the IV group (52.0%) had acute hypotension documented within 2 hours after, receiving pentamidine (p=0.59). Although hypotension is frequently seen in patients receiving pentamidine, we were unable to demonstrate a significant difference in its occurrence by the route of administration. |
| W-29 | A-DIFLUORANETHYLORNITHINE (DFMO) IN THE TREATMENT OF CRYPTOSPORIDIOSIS IN AIDS PATIENTS: PRELIMINARY EVALUATION Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-29 K Rolston, V Fainstein, P Mansell, S Joerdsma, GP Bodey. No serious side-effects (hematologic, hepatic, renal) were encountered although frequent nausea and occasional vomiting occurred. Audiometric studies in patients who received >1 wk of therapy revealed no hearing impairment. DFMO may be a promising new drug for the treatment of Cryptosporidiosis, but much larger clinical experience is needed to evaluate its efficacy. |
| W-30 | TREATMENT OF CRYPTOSPORIDIOSIS IN AIDS PATIENTS WITH A-DIFLUOROMETHYLORNITHINE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-30 Rosemary Soave, A Sjoerdsma, MJ Cawein. DFMO appears to have promising anti-cryptosporidial activity but clinical use is limited by significant, though reversible toxicity. These results indicate that further studies of DFMO for cryptosporidiosis are warranted. |
| W-31 | CRYPTOSPORIDIOSIS (INTESTINAL & RESPIRATORY) AND ISOSPORIASIS IN ACQUIRED IMMUNE DEFICIENCY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-31 Pearl Ma, D Kaufman, J Tsaihong, R Soave, S Carter, P Guigli. From 1981-84 Cryptosporidiosis was diagnosed in 90 patients from greater New York area by the 3-step stool examination (iodine modified cold kinyoun-sucrose flotation). Sixty cases had AIDS, 5 AIDS related complex (ARC), and 25 were immunocompetent (traveler's diarrhea, nosocomial infections). The AIDS and ARC groups suffered from intermittent/chronic, watery/semisolid diarrhea, abdominal pain, nausea, headache, and weight loss. |
| W-32 | EVALUATION OF EFFICACY OF SPIRAMYCIN IN INTESTINAL CRYPTOSPORIDIOSIS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-32 D Spicehandler, B Agins, W El-Sadr, MS Simberkoff, and JJ Rahal. Spiramycin may have a suppressive effect on CRS in some pts with AIDS. In HH and ARC spontaneous clearance of CRS is frequent. |
| W-33 | CLINICAL SPECTRUM OF DISSEMINATED CYTOMEGALOVIRUS INFECTIONS IN THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-33 Richard B Pollard, D Matzke, JD Bell, KM Ramsey. Infections with CMV can occur asymptomatically or with a wide range of clinical presentations in AIDS, and remain a major cause of morbidity and mortality. |
| W-34 | UNUSUAL SEVERE AND RECALCITRANT BACTERIAL INFECTIONS IN MALE HOMOSEXUALS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-34 Lawrence A Cone, DR Woodard, RG Byrd. Due to a perturbation of T-cell function, opportunistic infections by viral, protozoan, mycobacterial and fungal agents characterize the clinical picture of AIDS. Less commonly appreciated is the proclivity of such individuals or those with the AIDS-related complex to develop unusually severe bacterial infections. |
| W-35 | SHIGELLA FLEXNERI BACTEREMIA IN PATIENTS WITH AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-35 Jordan B Glaser, D Zimmerman, C Gulans, S Landesman. A review of microbiology records revealed no other cases of Shigella bacteremia in the last four years. Gastroenteric isolates in adults were equally divided between Sh. flexneri and other Shigella groups as opposed to bacteremic isolates which were exclusively Sh. flexneri.- Shigella bacteremia may occur in AIDS patients from populations that may have an increased exposure to the organism (i.e. Haitian or homosexual). |
| W-36 | DISSEMINATED COCCIDIOIDOMYCOSIS PRESENTING AS THE INITIAL INFECTION IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-36 Donald J Salberg. This case suggests that dissemination of coccidioidomycosis may occur as an initial opportunistic infection in AIDS. |
| W-37 | BACTERIAL PNEUMONIA IN PATIENTS WITH AIDS Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-37 Bruce Polsky, J Dryjanski, JWM Gold, AE Brown, G Schiffman, D Armstrong. Opportunistic infections (OI) in AIDS patients are mostly associated with a T-cell defect; however, the inability of B-cells to respond appropriately to antigenic stimuli has also been described. While Pneumocystis carinii pneumonia (PCP) is the most common serious OI and cause of pneumonia in AIDS patients, we have seen 14 episodes of primary bacterial pneumonia in 10 AIDS patients at MSKCC. Six patients had 1 episode and 4 had 2 episodes each. All patients had signs and symptoms of a respiratory illness at presentation as well as polyclonal elevations in serum IgG. |
| W-38 | A 24 MONTH PROSPECTIVE STUDY OF THE OPHTHALMOLOGIC FINDINGS IN THE ACQUIRED IMMUNE DEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-38 Jonathan Mines, MD, William Freeman, MD, Chester Lerner, MD, Brie Mandel, MD, Evan Bell, MD, Michael Starr, MD, Michael Tapper, MD, and Alfred Nadel, MD We performed a 24 month prospective study of the eye findings in AIDS, including a total of 59 patients. Follow-up of patients from their initial diagnosis of AIDS until death was available for 31 patients, while 21 patients were alive at the end of the study and 7 were lost to follow-up. Multiple ocular examinations were performed in 35 patients, 22 of whom died during the study. Average case mortality rates in our study group correlate with national statistics. Contrary to others, our report fails to substantiate a relationship between eye abnormalities and death rates. We conclude that limited survival is not predicted by ocular abnormalities in AIDS and that serial exams show evolving ocular findings. |
| W-39 | IS CYTOMEGALOVIRUS (CMV) A CAUSE OF LUNG DISEASE IN PATIENTS WITH AIDS? Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-39 Howard R Brodie, C Broaddus, W Blumenfeld, PC Hopewell, A Moss, J Mills. Recovery of CMV from the lung of AIDS patients with PCP has no demonstrable effect on mortality. Occasional patients with very large amounts of virus may have a shorter life span possibly due to CMV; selective therapy with specific antiviral nucleoside analogs may help determine the role of this virus in AIDS lung disease. |
| W-40 | TREATMENT OF CYTOMEGALOVIRUS DISEASE IN AIDS PATIENTS WITH 9- (1, 3-DIHYDROXYL-2-PROPOXYMETHYL)GUANINE Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-40 Lawrence J Eron, HC Lane, C Toy, L Harvey, E Gelman, H Masur. These preliminary results suggest that 9- (1, 3-dihydroxy-2-propoxymethyl) guanine can be effective in AIDS patients with CMV disease. Some type of maintenance regimen will probably be necessary since relapses occur promptly although granulocytopenia may be a dose limiting adverse effect. |
| W-41 | USE OF DANAZOL IN AUTOIMMUNE THROMBOCYTOPENIA ASSOCIATED WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-41 Margaret A Fischl, YS Ahn, N Klimas, WJ Harrington, M Fletcher. Recognition of an autoimmune thrombocytopenia associated with AIDS introduces several problems in patient management as most measures in treatment are themselves immunosuppressive. Danazol, an attenuated androgen, has been used in ITP and its mode of action may be more selective. Accordingly, 8 patients with AIDS or ARC and thrombocytopenia were treated with danazol. Danazol was given at 800 mg per day for 6 mos. Of 8 patients treated, 4 had opportunistic infections and 4 had chronic lymphadenopathy, weight loss, and oral thrush. All had a severe defect in cellular immunity. |
| W-42 | OPEN TRIAL OF INTRAVENOUS GAMMA GLOBULIN (IVGG) FOR AIDS-RELATED THROMBOCYTOPENIA (TP). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-42 Edward J Gindi, Michael H Grieco. Low dose IVGG appeared to be effective in improving thrombocytopenia in patients with AIDS. |
| W-43 | LUPUS ANTICOAGULANT IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-43 Elena J Bloom, DI Abrams, GM Rodgers. We subsequently observed 34 consecutive patients hospitalized with a diagnosis of AIDS who had routine PTT performed. Twenty-four had prolonged PTT. None had evidence of clinical bleeding. Thus, prolonged PTT is a common finding in our hospitalized AIDS population. If no clinical history of bleeding is noted, the LA should be evaluated as a likely cause of PTT prolongation. This is important since many AIDS patients require invasive procedures for their management, and the LA, an in vitro phenomenon, should not prevent these studies. |
| W-44 | ACID STABILITY OF INTERFERON (IFN) IN SERA OF HEALTHY HOMOSEXUALS AND IN PATIENTS WITH AIDS OR AIDS RELATED COMPLEX, (ARC). Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-44 Elena Buimovici-Klein, M Lange, MH Grieco, LZ Cooper and RJ Klein. The sera of 100 healthy homosexuals, of 16 patients with ARC and of 20 AIDS patients were examined for the presence of IFN. The nature of IFN was determined by neutralization with IFN type-specific antisera and by exposure of sera to low pH. Healthy homosexuals were tested sequentially times, and patients with ARC or AIDS at least 3 times, at intervals of 6 to 9 months. |
| W-45 | IN VITRO IMMUNOMODULATORY EFFECTS OF INTERLEUKIN-2 AND THYMOSIN FRACTION V IN AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-45 Mohan M Reddy, MH Grieco, ML Moriarty. The effects of Interleukin-2 (IL-2) and Thymosin Fraction V (TFV) were studied in vitro on lymphocyte proliferative responses and IL-2 receptor (IL-2R)expression on PHA stimulated lymphocytes obtained from 7 normal heterosexual men, 5 patients with AIDS related complex (ARC) and 8 patients with AIDS. |
| W-46 | ADMISSION OF ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) IN INTENSIVE CARE UNIT (ICU) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-46 Christine Katlama, B Regnier, M Wolff, E Rouveix, P Drollet, F Vachon. Our opinion is that acute visceral failure related to potentially treatable opportunistic infections or severe hydroelectrolytic. disorders could benefit from intensive cares. By contrast, prolonged and wasting diseases with no available therapy should not be accumulated In ICU. When artificial ventilation is required, weaning is unlikely, unless achieved within a few days. |
| W-47 | ASSOCIATION OF HTLV-III WITH RISK FACTORS FOR AIDS IN GAY MEN FROM A LOW INCIDENCE AREA Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-47 Charles Rinaldo, L Kingsley, D Lyter, B Rabin, R Atchison, S Weiss. These results indicate that Pittsburgh may be undergoing the early stages of spread of HTLV-III in gay males that is associated with a low but increasing incidence of AIDS. Augmentation of suppressor/cytotoxic T cells may be an early manifestation of HTLV-III infection that could be related to activation of EBV and CMV. |
| W-48 | THE CLASSIFICATION OF HTLV-III INFECTION IN A SUBURBAN COMMUNITY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-48 Mark H. Kaplan, SG Pahwa, M Popovic, MG Sarngadharan, RC Gallo. We had an inordinate amount of transfusional AIDS (4/32), 1 transfusional LAD. Two infants had congenital neurologic damage with cranial lucencies and microcephaly. Considerable spread occurred mother to child, male - male companion. HTLV-III is spreading in epidemic proportion in our community. |
| W-49 | HTLV-III ANTIBODIES AND T CELL SUBPOPULATIONS IN HOMOSEXUAL MEN IN SWEDEN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-49 G Biberfeld, M Bottiger, A Karlsson, L Moberg, E Sandstrom, L Morfeld-Mansson, C Saxinger. 203 homosexual (HS) men, most of whom participated in a health control study of HS men in Stockholm, were examined for serum antibodies to HTLV-III and for alterations of T cell subsets. Sera were screened for antibodies by an enzyme linked immunosorbent assay and/or a dot immunobinding assay and positive reactions. were confirmed by Western blotting. |
| W-50 | NUMBER OF T-CELLS, SEXUAL PRACTICES AND HTLV-III ANTIBODY IN HOMOSEXUAL MEN Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-50 R Detels, Barbara Visscher, J Sever, J Fahey, V Clark, D Madden, M Gottlieb. These results suggest an association in this population between sexual practices, levels of Leu-3 (T-helper) cells and presence of HTLV-III antibody. |
| W-51 | FACTORS AFFECTING SERA-POSITIVITY FOR HTLV-III INFECTION IN SEXUAL PARTNERS OF PATIENTS WITH AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-51 Jonathan N Weber, A MacReaner, D Houghton, DJ Jeffries, AJ Pinching, JRW Harris. All these patients have remained AIDS-free over a period of 14 months. Seropositivity was associated with more frequent intercourse with an AIDS case. However, 6 patients remained seronegative despite regular sexual intercourse with an AIDS case for more than 1 year and within 6 months of the development of AIDS. |
| W-52 | SEXUAL PRACTICES AND OTHER LIFESTYLE VARIABLES ASSOCIATED WITH HTLV-III SEROPOSITIVITY IN HOMOSEXUAL MEN WITH AND WITHOUT GENERALIZED LYMPHADENOPATHY (GL) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-52 Kenneth H Mayer, D Ayotte, AM Stoddard, JE Groopman. Eighty-six gay men from a community health center or a hospital practice received a physical exam and questionnaire in late 1983-Spring 1984. 36/40 (90%) with GL were (+) for HTLV-III antibody (Ab) as opposed to 9/46 (19.6%) who were asymptomatic. |
| W-53 | IMMUNOLOGICAL PROFILE OF HOMOSEXUAL/BISEXUAL MEN IN SAN FRANCISCO NEVER ORALLY OR ANALLY INSEMINATED Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-53 Marcus Conant, L Drew, J Levy, C Casavant, F Baumgartner, P Volberding. The purpose of this study was to examine the immunological profiles of homosexual/bisexual men closely exposed to the gay community, but who, theoretically, had never been exposed to the AIDS retrovirus. We recruited 10 such men regularly engaging in homosexual practices, but who denied ever engaging in oral or anal insemination. Each of the individuals was examined; lymphadenopathy and other infections suggestive of immunosuppression were found in none. |
| W-54 | LONGITUDINAL STUDIES ON CELLULAR IMMUNITY IN A COHORT OF 110 SYMPTOM-FREE HOMOSEXUAL MEN IN LONDON WITH REFERENCE TO HTLV-III SEROLOGY AND DEVELOPNENT OF DISEASE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-54 AJ Pinching, JN Weber, LA Rogers, EL Berrie, DJ Jeffries, JRW Harris. A cohort of 110 symptom-free homosexual men was recruited in 1982-1983 in London. These have been studied clinically, microbiologically and immunologically over the succeeding two years. Two have developed AIDS, 18 have developed persistent lymphadenopathy but the remainder are well. In 1984, their seropositivity rate for HTLV-III was 35%. |
| W-55 | BEHAVIORAL FACTORS AND LABORATORY TESTS IN HOMOSEXUAL MEN ASSOCIATED WITH HTLV-III ANTIBODY POSSITIVITY Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-55 Peter Gill, Eric Jeffries and William J Boyko. Alterations of immune function identified were related to HTLVIII status but appeared to be independent of disease expression of PGL. |
| W-56 | A REPORT OF CLINICAL, HEMATOLOGICAL, AND IMMUNOLOGICAL ABNORMALITIES IN AIDS VIRUS (MV) SEROPOSITIVE AND SERONEGATIVE MEN FROM A RANDOM SAMPLE OF SINGLE MEN IN SAN FRANCISCO Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-56 Robert E Anderson, MD, Jay A Levy, MD, Herbert A, Perkins, MD, William Lang, MD, Vyas, Girish, PhD Statistically significant reduction in the absolute helper (Leu 3a) cell population is seen in ARV seropositive men when compared with , ARV seronegative men with homosexual contacts, and with heterosexual ARV negative men. Loss of, helper cells results in lowered counts of T-cells, total lymphocytes, and total white cells. Increased prevalence of skin test anergy, clinical abnormalities such as lymphadenopathy and hairy leukoplakia, and immune complexes are also seen. |
| W-57 | T-LYMPHOCYTE SUBPOPULATION ABNORMALITIES IN APPARENTLY HEALTHY HOMOSEXUALS, HOMOSEXUALS WITH RECURRENT OPPORTUNISTIC INFECTIONS AND AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-57 Deja Tanphaichitra, S Sahapongs, K Amataykul, S Srimuang. Serology for Legionella was positive and adverse reaction to spiramycin was observed in patient with AIDS, and in another compromised patient with Cryptosporidiosis. However these homosexuals without AIDS with abnormal T-lymphocyte population remain healthy. |
| W-58 | A TWO YEAR PROSPECTIVE STUDY OF CLINICAL AND IMMUNOLOGICAL PARAMETERS OF THE AIDS PRODROME. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-58 Hardy Kornfeld, M Lange, E Buomoivici-Klein, KE Weiss, LZ Cooper, MH Grieco. A cohort of 114 healthy homosexual men was recruited in 1981/1982 and evaluated at 6 months intervals for 24 months to study the AIDS prodrome. On entry, the T4/T8 ratio was below the minimum value (1.4) of a group of 20 heterosexual controls in 83% of homosexual volunteers. The low ratio was due to both a lower total T4 counts and a higher total T8 counts. |
| W-59 | UNEXPLAINED LYMPHADENOPATHY IN HOMOSEXUAL MEN: A LONGITUDINAL STUDY OF CLINICAL AND LABORATORY PARAMETERS IN MEMBERS OF A COHORT WHO HAVE NOT BEEN DIAGNOSED WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-59 Daniel B Fishbein MD; Jonathan E Kaplan MD; Thomas J Spira MD; Bess Miller MD; Lawrence B Schonberger MD. There has been no significant change in the proportion of persons reporting fatigue, night sweats, fevers, or diarrhea or the number of extrainguinal lymph nodes. Laboratory parameters, including hematocrit, the absolute number of white blood cells, lymphocytes, T-helper cells (T4), T-suppressor cells (T8), and the T4:T8 ratio have also remained largely unchanged. Except for the development of AIDS, the features of LAS have been unremitting for the majority of patients. |
| W-60 | PROGNOSTIC INDICATORS IN PERSISTENT GENERALIZED LYMPHADENOPATHY Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-60 Peter R Wolfe, MS Gottlieb, JL Fahey, S Knight, D Hardy, L Eppolito. In homosexual males the correlation of unexplained lymphadenopathy with evidence of exposure to HTLV-III is close but not absolute. The combined use of HTLV-III serology and determination of absolute helper T cell numbers permits improved definition of AIDS risk group members with lymphadenopathy. Supported in part by a grant to the UCLA AIDS Center from the University of California Task Force on AIDS |
| W-61 | T-SUBSET ALTERATIONS IN HOMOSEXUAL MEN: RELATIONSHIP TO HTLV-III/LAV INFECTION Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-61 Janis Giorgi, PG Nishanian, R Afrasiabi, R Detels, JL Fahey. Most men who were seropositive for HTLV-III had decreased numbers of Leu3+Leu8+ cells. In contrast, the Leu3+Leu8- cells were increased in some seropositive individuals, normal in others, and decreased in many. Our results suggest that Leu 3 cells are activated early in the course of viral infection leading to elevations in the Leu3+Leu8- cells, but that loss of this subset occurs as immune changes progress. Leu2+Leu8+ cells were present in normal numbers in most seropositive individuals, but the Leu2+Leu8- cells were usually elevated. Since this elevation was also observed in homosexual men who were seronegative for HTLV-III, the elevation in the Leu2+Leu8- subset does not seem to be specific for HTLV-III infection. |
| W-62 | PERSISTENT GENERALIZED LYMPHADENOPATHY IN HOMOSEXUAL MEN: A 40 MONTH FOLLOW UP AND RESULTS OF LAV SEROLOGY MEASURED BY IGG ELISA. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-62 U Mathur-Wagh, D Mildvan, SR Yancovitz, I Spigland, F Brun-Vezinet, F Barre-Sinoussi, L Montagnier, JC Chermann. Conclusions: 1) PGL is frequently complicated by AIDS, 2) Changes in lymph-node size point to the diagnosis of KS or PCP, and 3) the prevalence of antibody to LAV in this cohort of PGL patients adds to evidence implicating LAV as the cause of PGL and AIDS. |
| W-63 | CLINICAL CHARACTERISTICS OF A COHORT OF GAY MEN WITH GENERALIZED LYMPHADENOPATHY (GL) IN BOSTON Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-63 Kenneth H Mayer, D Ayotte, JD Allan, JE Groopman. The most common symptoms associated with GL were: persistent fevers (33%), malaise (28%), night sweats (23%), > 10% weight loss (17%), unexplained diarrhea (11%). > 1/3 of the patients had normal labs and no symptoms; none developed AIDS, nor did those with malaise alone and normal labs. No one in the GL group for > 1 year developed AIDS in the past year. The majority have noted symptom remission, suggesting stabilization of chronic GL, although new thrush has been noted after GL diagnosis. |
| W-64 | ONE YEAR FOLLOW-UP OF MEN EXPOSED TO AIDS IN SAN FRANCISCO. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-64 Andrew R Moss, D Osmond, P Bachetti, D Abrams, F Barre-Sinnoussi, JCC Shermann. All subjects were recalled for examination at anniversary date and a subset were recalled for detailed study at 6 months. We report 6 and 12 month followup results, including (a) seroconversion to LAV ab+, (b) progression to frank, CDC-defined AIDS, (c) progression to pre-AIDS symptomatology, and (d) changes in immune status. |
| W-65 | RELATIONSHIP BETWEEN ANTIBODY TO LAV/HTLV-III AND THE NATURAL COURSE OF CELLULAR IMMUNODEFICIENCY IN HOMOSEXUAL MEN. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-65 AC Collier, JD Meyers, VL Murphy, PL Roberts, JP Getchell, HH Handsfield. Prevalences of antibody to LAV/HTLV-III were 97% in 102 homosexual men with Persistent generalized lymphadenopathy (PGL), 32% in 44 homosexual men without PGL attending a STD clinic (Hom-STD), 22% in 23 homosexual male university students, and 4% in 22 heterosexual men at a STD clinic. In the 3 groups of homosexual men combined, the presence of anti-LAV/HTLV-III was positively correlated with increased lifetime sex partners (P=0.002), past history of STD (P=0.002), and anergy to a panel of 4 skin test antigens (P=0.002), and was negatively correlated with T4:T8 ratio (P=0.0002) and absolute T4 lymphocyte count (P=0.000. |
| W-66 | SEROEPIDEMIOLOGY OF HTLV-III, IMMUNOLOGIC STATUS AND DISEASE OUTCOME IN A COHORT OF 250 DANISH HOMOSEXUAL MEN, 1981-84. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-66 Mads Melbye, RJ Biggar,P Ebbesen, MG Sarngadharan, SH Weiss, RC Gallo. A cohort of 250 Danish homosexual men which was initially surveyed in 1981 has been followed yearly with respect to clinical condition,immunologic status and serologic parameters. Analysis for antibodies against the human T-cell leukemia (lymphotropic) virus (HTLV-III) showed positivity in 22 (8.8%) of the men already in December, 1981, and frequency of seroconversion from absence to presence of HTLV-III antibody in this cohort appeared to be about 1% a month during the period December, 1981 to February, 1983. |
| W-67 | THE MULTICENTER AIDS COHORT STUDY (MACS): A PRELIMINARY REPORT. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-67 Richard A Kaslow, AJ Saah, A Monjan, RE Solomon for MACS. From the initial evaluation, information collected on relevant medical history, sexual practices, and exposure to selected drugs and procedures permits comparisons among the 5 MACS cohorts and between MACS participants and other groups of homosexual men at risk for AIDS. Screening for antibody to HTLV-3 in individuals sampled from each cohort will yield preliminary data on correlations of HTLV-3 infection with baseline epidemiologic characteristics. |
| W-68 | PREVALENCE OR ANTIBODIES TO HUMAN T-CELL LEUKEMIA (LYMPHOTROPIC) VIRUS, TYPE-III (HTLV-III) IN PARENTERAL DRUG ABUSERS (PDA) ATTENDING A METHADONE CLINIC. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-68 Donald E Craven, LM Kunches, JE Groopman, BG Werner. The data indicate that there is a high prevalence and spectrum of antibodies to HTLV-III among asymptomatic PDAs at tending a methadone clinic in 1982-83. Analysis of serial subsequent specimens from patients with different serologic profiles may help define early markers of seroconversion or correlate with the development of AIDS. |
| W-69 | HTLV-III/LAV ANTIBODIES IN INTRAVENOUS DRUG (IV) ABUSERS--COMPARISON OF HIGH AND LOW RISK AREAS FOR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-69 Thomas J Spira, DC DES Jarlais, D Bokos, R Onichi, D Kiprov, VS Kalyanaraman. These results suggest that the rate of exposure is higher in older heavier abusers compared with more recent heavy abusers and that, while cases are few in Chicago and San Francisco, there is a great potential for increased numbers if prevention measures are not instituted. |
| W-70 | ISOLATION OF HTLV-III/LAV VIRUS FROM PATIENTS WITH CLINICAL AIDS AND NORMAL CONTROLS IN ZAIRE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-70 Joseph B McConmick, SW Mitchell, JW Krebs, P Feorino, T Quinn, P Piot. Thirty-eight patients with clinical AIDS and abnormal T-helper to suppressor ratios were studied for the presence of HTLV-III/LAV virus in peripheral lymphocytes. In addition 10 patients who were suspected to have AIDS and 27 controls were tested. Twenty-three of 31 patients tested had HTLV-III /LAV virus isolated from peripheral lymphocytes. Three or 4 suspect cases had virus isolated from lymphocytes. |
| W-71 | SEROLOGIC AND IMMUNOLOGIC STUDIES ON HTLV-III AND OTHER INFECTIONS IN AFRICAN AND U.S. AIDS PATIENTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-71 Thomas C Quinn, P Piot, J McCormick, BM Kapita, N Mbendi, H Taelman. In order to examine the possible etiologic role of several infectious agents in AIDS, serologic studies for infection with HTLV-III, cytomegalovirus, Epstein-Barr virus, Hepatitis A and B viruses, herpes simplex virus, syphilis and toxoplasmosis were performed in 38 African AIDS patients and 200 African control patients. For comparison, similar studies were performed on 60 AIDS patients, 100 homosexual men and 200 heterosexual men from the U.S. Except for HTLV-III, there was no significant difference in the prevalence of antibodies to any of the above pathogens among African and American AIDS patients, and African and U.S. homosexual control patients. |
| W-72 | THE PRESENCE OF ANTIBODIES TO AIDS-ASSOCIATED RETROVIRUS (ARV) IN PATIENTS AND ASYMPTOMATIC INDIVIDUALS FROM OSLO, NORWAY. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-72 Jan C Ulstrup, G Pettersen, and JA Levy. These results indicate that the virus most likely responsible for AIDS was present in Oslo as early as 1981, and is closely associated with the development of AIDS in Norway. |
| W-73 | OUTBREAK OF NO IDENTIFIABLE RISK ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) IN BELLE GLADE, FLORIDA Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-73 Mark E Whiteside, D Withum, D Tavris, C MacLeod. Analysis of data from Belle Glade suggests that environmental Tactors contribute to development of AIDS in this region. |
| W-74 | HTLV III INFECTION IN THE UNITED KINGDOM (U.K.) Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-74 C Carne, IVD Weller, S Sutherland, R Cheisong-Popov, RB Ferns, P Williams, A Mindel. By November 13th 1984 90 cases of A.I.D.S. had been reported in the U.K., 77 in homosexual/bisexual men. In this major London STD clinic, during the week 22nd-26th March 1982 serum was saved from all men who had blood taken for syphilis serology (262 sera). This procedure was repeated during the week 16th-20th July 1984 (270 sera), 6 patients with P.G.L. or A.I.D.S. were excluded. Sera were examined for anti-HTLV III using a competitive inhibition radioimmunoassay previously described. |
| W-75 | ANTIBODY TO HTLVIII IN BRITISH HOMOSEXUALS, HEMOPHILIACS AND DRUG ADDICTS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-75 Philip P Mortimer, MS Pereira, WJ Jesson and EM Vandervelde. In contrast to these high prevalence 2.5% (n 203) of British intravenous drug Abusers were anti-HTLVIII positive. |
| W-76 | INCREASED RISK FOR HODGKIN'S DISEASE AND NON HODGKIN'S LYMPHOMAS IN A POPULATION AT RISK FOR AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-76 Tauseef Ahmed, G Wormser, R Stahl, A Mittelman, M Friedland and Z Arlin. IV drug abuse (IVDA) has been defined as a risk factor for AIDS among prisoners (prs), of whom 41% have a history of IVDA. Recently, we noted Hodgkin's Disease (HD) and Non-Hodgkin’s Lymphoma (NHL) in several prs prompting a search for patients (pts) with lymphoma and a history of IVDA. 23 pts including 20 prs were identified. 18 pts had NHL and 5 had HD. All of the pts with NHL had diffuse lymphoma although 2 had areas of residual nodularity. One pt had concurrent Pneumocystis carinii, but none had Kaposi's sarcoma. |
| W-77 | HTLV-III SEROPOSITIVITY IN HAITIANS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-77 E Frank, S Weiss, J Weber, JC Compas, W Blattner, Sheldon Landesman. These data indicate that exposure to the putative AIDS agent .(HTLV-III) among Haitians in New York City is very low and justifies the New York City declassification of Haitians as a high risk group. |
| W-78 | HTLV-III ANTIBODY PREVALENCE IN HOMOSEXUAL AND HETEROSEXUAL ADULTS IN MONTREAL. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-78 Norbert Gilmore, M O'Shaughnessy, J Weber, P Gill, E Goldbergr, Le Blanc, O Rosengren. This cross-sectional study of a representative metropolitan population of homosexual men indicates HTLV-III infection is extensive among asymptomatic homosexual men. |
| W-79 | THYMOSIN IN THE DIAGNOSIS, STAGING AND TREATMENT OF AIDS AND AIDS RELATED IMMUNDE DYSFUNCTION. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-79 PH Naylor, AL Goldstein, R Schulof, G Simon, G Sztein, C Kessler. Individuals with AIDS have a more severe form of thymus-mediated immune dysfunction and immune paralysis than homosexuals and hemophiliacs - "at risk" for AIDS. HTLV-III antibody studies have indicated a wide spread exposure of at risk groups to the virus implicated in AIDS. |
| W-80 | UNDERSTANDING THE NATURAL HISTORY OF AIDS, IN WEST-GERMANY. SEROEPIDEMIOLOGICAL STUDIES IN HEALTHY HOMOSEXUAL MEN, A COMBINED BIOLOLICAL AND PSYCHOSOCIAL APPROACH. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-80 Hans Jasger; K Berlit, S Kellermann, W Köpcke, G. Riethmüller, F Deinhardt. The average number of lifetime partners was 256, with higher numbers in those participants positive for HTLV III antibody and those with a decreased helper/suppressor cell ratio. Specific data on life style, coming out process and partnership was collected. |
| W-81 | PREVALENCE OF HTLV-III ANTIBODIES IN WEST-BERLIN AND GERMANY DETERMINED BY ELISA AND/OR WESTERN BLOT ANALYSIS USING AN ANTIGEN PREPARED BY A SIMPLE TWO STEP PROCEDURE. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-81 Georg Pauli, W Vettermann, E Jovaisas, U Marcus and MA Koch. No correlation could be found between reaction patterns in the Western blot and the clinical or laboratory abnormalities observed or with stage of disease. Antigen was prepared by simple differential centrifugation omitting detergent treatment. This allows, under laboratory conditions, the production of large amounts of anti gen. Thereby serological tests can be performed using excess amounts of antigen. |
| W-82 | CLINICAL AND LABORATORY FINDINGS IN HOMOSEXUAL MEN SEROPOSITIVE FOR HTLV-III. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-82 Meinrad A Koch, R Kunze, E Jovaisas, U Marcus, HD Heil, E Baranowski. The most consistently abnormal laboratory findings were reduced OKT4/OKT8 ratios and increased serum levels of neopterin and 13-microglobulin. This was most pronounced in patients with several clinical symptoms. All patients with seroconversion developed lymphadenopathy and their OKT4/OKT8 ratios decreased. None of 133 seropositive patients with clinical symptoms and/or abnormal laboratory findings showed improvement during the, period of observation. Nine patients developed disease meeting the CDC criteria for AIDS. |
| W-83 | OCULAR MANIFESTATIONS OF AIDS. Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. W-83 Gary N Holland, JS Pepose, AE Kreiger, RY Foos. A study of 65 patients at UCLA revealed that ocular disease is a common manifestation of AIDS. Three year follow-up was obtained in some cases. Eyes from 35 patients were examined at autopsy; light and electron microscopy and immunochemical techniques were used on selected eyes. |
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