1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S3E)

William A Haseltine, J Sodroski, C Rosen, F Wong-Staal, R Gallo
Dana-Farber Cancer Institute, Boston, Massachusetts, and NCI, NIH, Bethesda, MD

Transcription directed by the long terminal repeat (LTR) elements of HTLV-I, HTLV-II, HTLV-III and bovine leukemia virus (BLV) is markedly increased in trans by factors present in infected cells. The viral-associated trans-acting factors exhibit preference for the LTR type of the infecting virus, suggesting that a viral protein mediates this effect. Immunoprecipitation of viral proteins from infected cells reveals that proteins predominantly located in the nucleus are present, suggesting that these proteins may play a role in transcriptional effects. Examination of the target regions on the LTR for trans-activation reveals that sequences within the repetitive enhancer elements as well as proximal to the promoter (TATA) are necessary for trans-activation.

850414
S3E

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.