1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S4D)

Gorm Pallesen, J Gerstoft, LR Mathiesen, S Brask, E Dickmeiss, P Platz
Kommunehosp., Aarhus; and Hvidovre Hospital, Rigshosp., State Serum Institute, Copenhagen, Denmark.

Lymph nodes (LNs) from 30 homosexual men with lymphadenopathy syndrome (LAS) were studied by microscopy and monoclonal antibody immunohistologic staining to relate morphologic features with clinical and immunologic data. Changes of LNs were classified according to 3 stages that might be associated with progression of disease. Stage 1 included follicular hyperplasia, mantle zone depletion, follicular fragmentation, and follicular infiltration with T8-positive lymphocytes. Stage 2: signs of follicular atrophia. Stage 3: follicular depletion with angioimmunoblastic lymphadenopathy-like change followed by lymphocytic depletion and fibrosis. Without knowledge of clinical and immunologic data, LNs were classified as stage 1 in 15 cases, stage 2 in 7, and stage 3 in 8. Correlation with clinical data revealed that LAS without symptoms was associated with stage 1, 2 and 3 in 73%, 86% and 0%, respectively. LAS with symptoms was found in the stages in 13%, 14% and 62%. AIDS was detected in 5 patients, 2 had Kaposi's sarcoma and stage 1 histology whereas 3 had opportunistic infection and stage 3. Reduced T4:T8-ratio was significantly more pronounced in stage 3 than in 1 or 2. It is concluded that LN biopsy is valuable in the assessment of diagnosis, immune status and prognosis in patients at risk of AIDS.

850414
S4D

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.