1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:24 (abstract no. S5D)
Roeland A Coutinho, W Krone, N Albrecht-Van Lent, J Van Der Noordaa, J Goudsmit
Municipal Health Service and Academic Medical Center, Amsterdam, The Netherlands

A group of 800 homosexual men in and around Amsterdam participated in an efficacy trial with a heat-inactivated hepatitis B vaccine, which was conducted between November 1980 and December 1982. The first and the last bloodsample of a large part of the participants were tested for the presence of IgG antibodies to LAV/HTLV-III by ELISA, using lysed H9-HTLV-IlI as antigen and uninfected 119 as control.

Out of 679 sera collected at the intake of the study (November 1980 - December 1981), 2 were found to be anti-LAV/HTLV-III-IgG positive (2/₆₇₉ = 0.3%). Of 697 sera collected at the end of the study (second alf 1982) an additional 26 positive sera were found (28/₆₉₇=4.0%).

Up to the time of writing 1 of the 28 anti-LAV/HTLV-III seropositive men has developed AIDS (attack-rate 3.7%), while among the 669 seronegative men no AIDS-cases have been found.

From these data it appears that LAV/HTLV-III was introduced in the homosexual community in and around Amsterdam at the end of the seventies. It seems that only a minority of those persons seropositive for LAV/HTLV-III antibodies will develop full blown AIDS.

850414
S5D

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.