1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S6E)

Mikulas Popovic, D Mann, E Read-Connole, C Neuland, RC Gallo.
NCI, NIH, and Uniform Services University Health Sciences, Bethesda, Maryland.

Permanent human T cell lines were studied for infection and propagation of HTLV-III. The virus infects those cell lines which bear the OKT4 and Leu 3a antigens. In "early" infection when the virus attachment to cell surface takes place reduction of OKT4a and Leu 3a epitopes was found but not OKT4. The OKT4 gradually decreased over several days when full expression of HTLV-IIl occurred. Infection of T cells with HTLV-III was blocked by these monoclonal antibodies. However, T lymphocytes lacking the OKT4 epitope are susceptable to the virus infection indicating that HTLV-III utilizes a portion of T4 molecule as a receptor. Capability to utilize T4 differentiation antigen suggests that "early" infection can occur in non-activated T4+ lymphocytes.

850414
S6E

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.