DIAMINODIPHENYLSULFONE (DAPSONE) AS TREATMENT FOR PNEUMOCYSTIS CARINII PNEUMONIA IN AIDS PATIENTS IN COMBINATION WITH TRIMETHOPRIM
Int Conf AIDS. 1985 Apr 14-17;1:25 (abstract no. S7B) S Richardson, M Fanning, J Brunion, I Salit, S Read, F Shepherd.
University of Toronto, Canada.
The high frequency of adverse reactions to conventional therapy of Pneumocystis carinii pneumonia (PCP) in AIDS patients warrants a search for an efficacious, less toxic agent. Dapsone has been shown to be effective in a rat mxlel. We used Dapsone (100 mgs p.o./d.) and Trimethoprim (20 mgs/kg/d) for two weeks in a patient in when other treatment was contraindicated. Symptomatic aril radiologic resolution of pneumonia occurred within 7 d. One year later, PcP was not found at autopsy. Six more PCP/AIDS patients have received this treatment. Five had clinical resolution of PCP. No relapse has occurred (mean follow-up-3.6 mos.). Two patients had improvement but therapy was changed due to side effects; pancytopenia and hemolytic anemia. Other side effects include rash, 3 and pancytopenia, 1. Treatment of PCP with Dapsone and Trimethoprim appears to be effective but a high rate of side effects (71%), sane severe, may limit its usefulness.
850414
S7B
