1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S7E

WL Drew, S Mehalko, H Brodie, J Mills, R Neger, J O'Donnell
Mount Zion Hospital, San Francisco General Hospital Ralph K. Davies Medical Center, St. Luke's Hospital, and University California, San Francisco.

Four homosexual men with AIDS and culture positive CMV infection were treated with DHPG, 5 mgm/kg. I.V. 3 times daily for at least 10 days. Antiviral effect was demonstrated as follows:

Patient #1 received 2 separate 14 day treatments and subsequent intermittent single doses. More intense therapy was prevented by severe neuropenia. His last dose was 5 weeks prior to death. Patient #2 received DI-PG for 14 days and then 3 times per week until his death from P. carinii pneumonia. Patient #3 received 10 days of DHPG. Prior to treatment he was blind in one eye and had severe retinitis in the other. No autopsy was performed. Patient #4 also received 10 days of therapy but expired on the 10th day from his 3rd episode of P. carinii and CMV pneumonia. All 3 of the patients with retinitis had subjective and objective improvement in conjunction with a diminution in viruria, but patient 3's retina was culture positive at autopsy. Autopsy culture results for patient 1,2, and 4 were as follows:

We conclude that DHPG effectively suppresses CMV excretion and appears to provide clinical benefit for CMV retinitis. It does not eradicate CMV in severely immunocompromised AIDS patients.

850414
S7E

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.