1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:26 Abstract No. S8B

Donald I Abrams, T P Mess, and P Volberding
San Francisco General Hospital

Two hundred homosexual men with persistent diffuse lymphadenopathy of greater than 6 months' duration involving 2 or more extra-inguinal sites have been enrolled in a natural history study since November 1981. Seroepidemiologic evidence from studies of the lymphotropic retroviruses confirms that the syndrome is indeed an AIDS-related condition. 14 subjects have developed CDC-defined AIDS. 5 developed Kaposi's sarcoma. One patient developed an aggressive non-Hodgkin's lymphoma. 11 opportunistic infections have been diagnosed in the evolving patients. The AIDS diagnosis was made after 29 months of lymphadenopathy. 83% of the patients progressing to AIDS experienced shrinking peripheral adenopathy. The majority suffered more severe constitutional symptoms than the stable cohort. Other features of the 14 patients which distinguished them from the remainder of the group include a history of antecedent thrush, elevated erythrocyte sedimentation rate, a peripheral cytopenia and history of Herpes zoster infection. The lymphadenopathy syndrome represents a response to infection with the AIDS retrovirus with a minority of this group at risk to develop CDC-defined AIDS.

850414
S8B

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.