1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS. 1985 Apr 14-17;1:27 Abstract No. S8D

Michael Marmor, W Elsadr, S Zolla-Pazner, M Lyden, D Bebenroth, Sh Weiss

We have prospectively followed a random sample of 40 initially asymptomatic, homosexual men from a Manhattan medical practice. Prevalence of antibodies to HTLV-III increased from 20% (7/35) in 1981-2, to 33% (13/39) in 1983, to 36% (12/33) in 1984. Receptive anal-intercourse was a significant risk factor for HTLV-III seropositivity (odds ratio = 10.3; 1-tailed p=0.01). Seventeen subjects were seropositive at 1 or more samplings; no sero-reversions were observed. Eight who had HTLV-III antibodies at enlistment developed AIDS (2) or "suspected AIDS" (6). Of the other 9 who later developed HTLV-III antibodies, 9/9 have been hypergammaglobulinemic, 8/9 have had OKT4/AT ratios less than 1.0 due to reduced OKT4 percents, and 4/9 have developed suspected AIDS. of 23 subjects who were HTLV-III seronegative on all samplings, 8 have had significant lymphadenopathy, but none have had an immunologic profile consistent with AIDS (decreased OKT4 cells, increased OKT8, ≥ 1 one elevated immunoglobulin isotype, and elevated serum β₂ microglobulin). The cumulative incidence of AIDS or suspected AIDS was 0% (0/23) among HTLV-III seronegative subjects, and 71% (12/17) among HTLV-III seropositive subjects.

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S8D

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