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1st International AIDS ConferenceAtlanta, Georgia, U.S.A. - April 14-17, 1985 |
Int Conf AIDS. 1985 Apr 14-17;1:28 Abstract No. S9E
J. Allen McCutchan, J. Allen McCutchan, P. Spechko, G. Boss, F. Jensenet al
University California, San Diego and Cytotech Inc., La Jolla, California.
The significance of antibodies to LAV (LAV-Ab) in persons at risk of AIDS was investigated by stratifing 222 gay men into five groups based on clinical and immunological indicators: AIDS, AIDS-related complex (ARC), only one ARC sign or symptom (? ARC), only immune abnormalities (Imm. Abn.) , and no immune abnormalities (Imm. nl. = TH/TS > 1.0, reaction to at least 1 of 6 skin tests, and lymphocyte ecto-5'-nucleotidase >8). Results of ELISA for IgG and IgM LAV-Ab are shown below.
| DIAGNOSIS | AIDS | ARC | ? ARC | IMM. ABN. | IMM. NL |
| Number | 18 | 8 | 104 | 47 | 32 |
| % IgG + | 50 | 75 | 61 | 25 | 6 |
| % IgM + | 0 | 0 | 9 | 6 | 9 |
| % G or M+ | 50 | 75 | 64 | 26 | 13 |
| %M+ of all+ | 0 | 0 | 13 | 25 | 75 |
64% of gay men with one sign or symptom suggestive, but not diagnostic, of ARC and only 26% of asymptomatic gay men with immune abnormalities have LAV-Ab.3 of 4 gay men without immune abnormalities who had LAV-Ab were IgM +. We conclude 1) one sign or symptom of ARC is a better predictor of infection with LAV than asymptomatic immune abnormalities and 2) early in LAV infection persons are IgM+, but are often asymptomatic and sometimes without immune abnormalities.
850414
S9E
Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.
