3rd International AIDS Conference


Washington, DC, U.S.A. — June 1-5, 1987

[TITLE:] IN A COHORT OF HIV SEROPOSITIVE MEN FOLLOWED FOR 30 MONTHS, INITIAL LEU 3A T LYMPHOCYTE COUNTS PREDICT SUBSEQUENT DECLINES IN T CELL COUNTS, CLINICAL FINDINGS AND AIDS

Int Conf AIDS. 1987 Jun 1-5;3:1 Abstract No. M.3.2

William Lang1, R. Anderson2, W. Winkelstein, Jr.3, R. Royce3, H. Perkins4
1Children's Hospital of San Francisco, CA, 2California Department of Health Services, Sacramento, CA, 3UCB School of Public Health, Berkeley, CA, 4Irwin Manorial Blood Bank, San Francisco, CA.

From the San Francisco Men's Health Study, a prospective study of HIV infection in a population-based probability sample, 370 HIV-infected men were recruited. A subset of 206 men attended examinations every 6 months from June 1984 through December 1986. Initial Leu 3a counts were unimodally distributed and depressed compared to uninfected men. Over 30 months, the entire distribution shifted toward lower values. When the group was stratified according to initial Leu 3a count, declines of 18 to 30% occurred in all quartiles indicating depletion of Leu 3a cells regardless of initial values.

To explore the relationship of initial Leu 3a values to development of HIV related symptoms and AIDS, all 370 seropositive men were stratified into groups with less than 500 (n=100), 500-650 (n=92), 650-800 (n=81), and greater than 800 (n=97) initial Leu 3a cells. Among participants with less than 2 symptoms suggestive of HIV infection at outset, 25% with less than 500 Leu 3a cells developed increasing symptoms compared to 12% of those with greater than 800 Leu 3a cells. Twenty-four of the 37 AIDS cases occurred in the lowest group compared to 5 in the highest.

These findings suggest that HIV infection affects Leu 3a counts progressively in most people and that initial Leu 3a number is strongly predictive of clinical outcome in the ensuing 30 months.

870601
M.3.2

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