4th International AIDS Conference Stockholm, Sweden. — June 12-16, 1988

Int Conf AIDS. 1988 Jun 12-16;4:1.114 (abstract no. 1006)

H Gelderblom¹, T Winket¹, H Reupke¹, JP Rabanus¹, M Niedrig¹, A Goldstein², P Sarinx³, G Pauli^1
1Robert Koch-Institut and AIDS Center Federal Health Administration, D-1000 Berlin, ²Georg Washington University, Washington DC, ³National Cancer Institute, NHI, Bethesda

Monospecific polyclonal rabbit and mouse mono–clonal antibodies directed against p17 reacted with epitopes located under the lipid bilayer of virions or budding particles. This immunological finding is substantiated by the direct EM observation of a matrix protein layer underneath the viral membrane. Antibodies produced against a distinct, synthetic fragment of p17 (HPG–30), which shows homology to thymosin, however, labelled in pre–embedding and cryoultramicrotomy IEM determinants on the surface of the virion or budding HIV. This observation is discussed in connection with neutralization data which indicate, that anti HPG–30 antibodies prevent the infection of susceptable cells by HIV.

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