5th International AIDS Conference


Montreal, Quebec, Canada — Jun 4-9, 1989



INCIDENCE OF HBV MARKERS AND HIV ANTIBODIES IN BLOOD DONORS IN LUANDA AND DUNDO, PEOPLE'S REPUBLIC OF ANGOLA

Int Conf AIDS 1989 Jun 4-9; 5:162 (abstract no. A.511)

Lourenco MH1, Cohen T2, Octavio F2, Santos-Ferreira MO1, Matos-Almeida MJ3, Azevedo Pereira JM1
1Lab. Virology, Fac. Pharmacy, Univ. Lisbon, Portugal; 2Agostinho Neto Univ. Med. School, Luanda, RP Angola; 3Hosp. Sta. Maria, Lisbon, Portugal

OBJECTIVE: To determine the prevalence of HIV 1 and HIV 2 infection and hepatitis B markers among a cohort of blood donors in two regions of Angola.

METHODS: The incidence of HBV markers and HIV antibodies was evaluated in 124 blood donors living in Luanda (74) and Dundo (50). Serological tests for detection of HIV antibody, include the specific HIV 1 and HIV 2 ELISA kits, IFA, W.B.. Cross-reactivity between HIV 1 and HIV 2 large glycoprotein were further tested against a synthetic peptide corresponding to the dominant epitope of transmembrane protein. Serological tests for detection of HBV markers were performed with ELISA kits.

RESULTS: As shown on table. Distribution of HIV antibody and HBs Ag, HBs Ab, HBe Ag and HBe Ab according to Laboratory

Service No.
Spec.		 Seropositivity No. (%)
HIV-1 HIV-2 HBs Ag HBs Ab HBe Ag HBe Ab
Luanda 74 – 1/74(1.4) 14/74 (18.9) 28/74 (37.8) 7/74 (9.5) 9/74 (12)
Dundo 50 3/50 (6.0) 8/50 (16.0) 21/50 (42.0) 21/50 (42.0) 10/50 (20) 13/50 (26)
TOTAL 124 3 (2.4) 9 (7.3) 35 (28.2) 49 (39.7) 17 (13.7) 20 (16.1)

DISCUSSION: The incidence of HBs Ag in sera from Luanda and Dundo is high. HIV 1 and HIV 2 infection exists among blood donors. The highest percentage of positive cases was in Dundo, Northeastern region, border of Zaire. The social and economic consequences of these problems have to be considered.

Keywords: Angola, Biological Markers, Blood Donors, Democratic Republic of the Congo, Enzyme-Linked Immunosorbent Assay, HIV Antibodies, HIV-1, HIV-2, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Antigens, Hepatitis B Core Antigens, Hepatitis B Surface Antigens, Hepatitis B virus, Incidence, Prevalence, epidemiology, immunology

1989-06-04
A511

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