5th International AIDS Conference


Montreal, Quebec, Canada — Jun 4-9, 1989

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Lymphadenopathy is a weak predictor of clinical outcome in HIV infection.

Int Conf AIDS 1989 Jun 4-9; 5:174 (abstract no. A.583)
Lang W, Anderson R, Royce R, Shiboski S; Children's Hospital, San Francisco, CA, USA

OBJECTIVE: To determine the relationship of lymphadenopathy to clinical outcome in HIV infection.

METHODS: Lymphadenopathy was measured by trained examiners in a population-based sample of 385 men from the San Francisco Men's Health Study who were seropositive at entry in Fall 1984. The incidence of symptoms of progressive HIV infection and of AIDS were determined at 42 months' follow-up.

RESULTS: The presence of greater than or equal to 2 extrainguinal nodes greater than or equal to 1 cm and the presence of total peripheral lymphoid mass greater than or equal to 10 cm were both associated with slight but not statistically significant increased risk of developing both HIV-related symptoms and AIDS. TABULAR DATA, SEE ABSTRACT VOLUME. In a multiple regression analysis controlling for CD-4, beta-2 microglobulin and symptoms, lymphadenopathy did not independently predict AIDS (p=0.7).

CONCLUSION: Lymphadenopathy measured in two ways predicts future development of clinical illness or AIDS only weakly in HIV infection.

Keywords: AEGIS, HIV Infections, Acquired Immunodeficiency Syndrome, Lymphatic Diseases, HIV, HIV Antibodies, beta 2-Microglobulin, HIV Core Protein p24, HIV Antigens, Leukocyte Count, Risk, San Francisco, Human, Male, diagnosis, ICA5KWDaegis,hivinfections,acquiredimmunodeficiencysyndrome,lymphaticdiseases,hiv,hivantibodies,beta2-microglobulin,hivcoreproteinp24,hivantigens,leukocytecount,risk,sanfrancisco,human,male,diagnosis,ica5

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A583

Copyright © 1989 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.