6th International AIDS Conference San Francisco, California, USA — June 20-23, 1990

Int Conf AIDS 1990 Jun 20-23; 6:318 (abstract no. 1018)
Suzuki M, Shinozaki F, Kobayashi S, Kobayashi N, Yamamoto N; Dept. of Maxillofacial Surgery, Yamaguchi University, School of Medicine, Ube, Yamaguchi, Japan

OBJECTIVE: Despite the fact that HIV can be detected in saliva of HIV-infected individuals, the risk of oral transmission of HIV has been shown to be extremely low. This study focuses on the mechanism of HIV inhibition by saliva from both HIV-infected and -uninfected individuals. The level of HIV antibodies in saliva was also investigated to determine whether or not antibodies of HIV in saliva behaved as HIV inhibitors.

METHODS: Saliva samples collected from both 7 HIV-uninfected (healthy) and 7 HIV-infected individuals were mixed with the same volume of HIV preparation. After incubation of various times (0,1,3,6,12,24h) at 37 degrees C, MT-4 cells were exposed to saliva/HIV mixtures. The expression of HIV-specific antigens was determined by the IF method. The levels of antigens and antibodies of HIV in serum and saliva were determined by EIA.

RESULTS AND CONCLUSION: Saliva samples from both HIV-infected and -uninfected individuals inhibited HIV infectivity. However, no significant difference in HIV inhibitory activity in both saliva specimens was observed irrespective of presence or absence of HIV antibodies in saliva. Further study suggested that this HIV inhibitory activity by saliva was due to the glycoprotein like substances.

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