6th International AIDS Conference


San Francisco, California, USA — June 20-23, 1990

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Early immune activation events after HIV infection.

Int Conf AIDS 1990 Jun 20-23; 6:336 (abstract no. 1089)
Melmed R, Fahey JL, Taylor JM, Detels R, Hofmann B, Rinaldo C, Saah A, Huprikar J, Munoz A, Kaslow RA, et al; Multicenter AIDS Cohort Study (MACS), Los Angeles, CA., USA

OBJECTIVE: To determine the frequency and scope of changes in beta-2 microglobulin (B2M) and neopterin (immune activation markers) following seroconversion and to relate these findings to subsequent changes in CD4 T cells and AIDS occurrence.

METHODS: B2M and neopterin were measured serially by RIA in the serum of 123 seroconverting men participating in MACS.

RESULTS: Both serum B2M and neopterin rose in the first seropositive samples in over 80% of the subjects. On the average, B2M increased by 47% and serum neopterin by 76% after seroconversion. Many individuals tended to maintain the levels reached in the first year, although some with low levels increased later and a few with high levels showed some decrease. The post-infection level of B2M and neopterin correlated (rho=-.47) with the CD4 T cell level 2 years later. The rises in B2M and neopterin correlated with each other (rho=.48). 20 individuals who developed AIDS within 3 years of seroconversion had high levels of B2M and neopterin at the rapid rate of CD4 T cell fall.

CONCLUSION: Immune activation (including increased serum B2M and neopterin) occurs promptly after HIV seroconversion and predicts fall in CD4 T cell levels.

Keywords: AEGIS, HIV Infections, Acquired Immunodeficiency Syndrome, HIV Seropositivity, Neopterin, Antigens, CD4, beta 2-Microglobulin, T-Lymphocytes, Biological Markers, Human, Male, ICA6KWDaegis,hivinfections,acquiredimmunodeficiencysyndrome,hivseropositivity,neopterin,antigens,cd4,beta2-microglobulin,t-lymphocytes,biologicalmarkers,human,male,ica6

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Copyright © 1990 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.