AEGiS-07IAC: Acquired protein S deficiency: correlation with advanced disease in HIV-infected patients.

7th International AIDS Conference


Florence, Italy — June 16-21, 1991

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Acquired protein S deficiency: correlation with advanced disease in HIV-infected patients.

Int Conf AIDS 1991 Jun 16-21; 7:262 (abstract no. M.B.2322)
Bissuel F, Berruyer M, Causse X, Dechavanne M, Trepo C; Hopital de l'Hotel-Dieu &INSERM U271, Lyon, France

OBJECTIVES: To evaluate the interest of measuring protein S (a vitamin K-dependent plasma protein which is involved in the degradation of clotting factors Va and VIIIa) in patients with HIV-1 infection and to assess the prevalence of free protein S deficiency in this population.

METHODS: Prospective analysis of blood samples from 63 HIV-1 infected patients (47 homosexuals or bisexuals, 10 heterosexuals and 6 intravenous drug addicts). Twenty-six had a confirmed diagnosis of AIDS, 25 were asymptomatic, 10 had polyadenitis, and 2 had ARC. A deep venous thrombosis occurred in 3 patients. Plasma protein S values were compared to a matched control group of 24 healthy subjects.

RESULTS: A significant decrease in free protein S concentrations was observed in HIV-1 seropositive patients (mean +/- SD, 56.5 +/- 23.3%) as compared with control subjects (105.3 +/- 18%), p=0.0001. Free protein values were significantly lower in patients with full blown-AIDS (37.6 +/- 12.3%) than in patients without AIDS (69.8 +/- 19.9%), p=0.0001. Low free protein S values correlated with either low CD4+ T cells counts (p=0.0002), high beta-2-microglobulin values (p=0.0001) and high urinary neopterin concentrations (p=0.005). A multiple regression analysis demonstrated that the progression to stage IV B, IV C1 or IV D of the Center for Diseases Control was the only explanatory variable in free protein S-deficient patients.

CONCLUSION: Free protein S deficiency may be an index of severity in HIV-1 infection associated with the development of AIDS. One possible explanation could be the binding of protein S to altered cells (including CD4+ T cells or macrophages) through interaction with membrane phospholipids.

Keywords: AEGIS, Protein S Deficiency, Acquired Immunodeficiency Syndrome, HIV Infections, Protein S, HIV-1, CD4 Lymphocyte Count, AIDS-Related Complex, Antigens, CD4, Homosexuality, Neopterin, T-Lymphocytes, Blood Proteins, Thromboembolism, Heterosexuality, Factor Va, Prevalence, Human, pathogenicity, diagnosis, ICA7
910616
MB2322

Copyright © 1991 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.