AEGiS-08IAC: Lack of increased risk of HIV perinatal transmission to subsequent siblings born to an HIV-infected mother. Perinatal AIDS Collaborative Transmission Studies Group.

8th International AIDS Conference

Amsterdam, Netherlands — July 19-24, 1992

Lack of increased risk of HIV perinatal transmission to subsequent siblings born to an HIV-infected mother. Perinatal AIDS Collaborative Transmission Studies Group.

Int Conf AIDS 1992 Jul 19-24; 8:We56 (abstract no. WeC 1057)
[No authors listed];

OBJECTIVE: To evaluate whether the second of 2 children born to a mother with known HIV infection is more likely to be HIV-infected (inf) than the first exposed sibling (sib).

METHODS: Sibs born to HIV-inf mothers and followed in 5 prospective HIV perinatal transmission studies in the U.S. were analyzed according to the HIV infection status of the sib relationship.

RESULTS: Of 107 sibships identified in these 5 studies, 69 (64%) of sib pairs thus far have a known infection outcome for both infants. The sibships' infection status is (status of first sib, followed by status of second sib, represented as one pair): TABULAR DATA, SEE ABSTRACT VOLUME. Overall, 22/69 (32%) of first sibs and 21/69 (30%) of second sibs were infected, both consistent with the background transmission rates in these studies. The rate of infection among second-born sibs was 32% (7/22) when the first sib was infected, compared with 29% (14/47) when the first sib was uninfected. These findings will be further evaluated in relation to the mother's clinical and immunologic status, obstetrical outcome, and spacing between the sibs.

CONCLUSION: Contrary to our expectations, we did not find an increased risk of infection in the second-born exposed infant, regardless of whether the first-born was infected or uninfected.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical, HIV Infections, Mothers, Risk, Prospective Studies, Risk Factors, United States, Child, Human, Infant, transmission, pathogenicity, ICA8
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