Maternal predictors of perinatal HIV transmission. The New York City Perinatal HIV Transmission Collaborative Study Group.
Int Conf AIDS 1992 Jul 19-24; 8:We56 (abstract no. WeC 1059) Thomas P, Weedon J;
OBJECTIVE. To identify characteristics in pregnant HIV+ women that predict transmission of HIV-1 to the infant. METHODS. Data including demographics, illicit drug use, STD history, clinical HIV illness, and CD4, immunoglobulin, and hemoglobin levels were collected on pregnant women at risk for HIV. Babies were followed to detect HIV infection using a modified CDC classification. Transmission rates for women with selected characteristics were calculated on the cohort who gave birth greater than 18 months ago. RESULTS. Of 324 HIV+ women enrolled, 129 had babies greater than 18 months ago with defined outcomes: 41 infected, 88 uninfected [Transmission rate (TR) = 32%]. TR for women with (TR1) and without (TR2) selected characteristics during pregnancy are shown: TABULAR DATA, SEE ABSTRACT VOLUME. Race, age, gravidity, prior STD history, injection and crack drug use, anemia (Hgb less than 10) and detectable P24 antigen were not associated with transmission. CONCLUSIONS. No single characteristic evaluated here predicts transmission for all HIV+ women. Women with clinical or immunologic evidence of HIV illness (including pneumonia) should be counseled that transmission may be increased. The association with parturient genital vesicles warrants further investigation.
Keywords: AEGIS, HIV, Disease Transmission, Vertical, HIV Infections, HIV-1, HIV Core Protein p24, New York City, Human, Female, Infant, Pregnancy, transmission, growth & development, ICA8 920719
WeC1059
