AEGiS-08IAC: The materno-foetal transmission rates of HIV-1 and of HIV-2 in France. The French Collaborative Study Group on HIV infection in Newborns.

8th International AIDS Conference


Amsterdam, Netherlands — July 19-24, 1992

Print this Article


The materno-foetal transmission rates of HIV-1 and of HIV-2 in France. The French Collaborative Study Group on HIV infection in Newborns.

Int Conf AIDS 1992 Jul 19-24; 8:We57 (abstract no. WeC 1063)
Rouzioux C, Mayaux MJ, Blanche S, Burgard M, Griscelli C; Hopital Necker-Enfants Malades, Paris, France.

OBJECTIVES: To determine the frequencies of the transmission of HIV-1 and HIV-2 from mother to child. PATIENTS: All newborns to HIV seropositive mothers born in 62 french hospitals are included in the French Prospective Study and followed prospectively.

METHODS: 1) The positivity for HIV-1 or HIV-2 is determined at delivery by using Western-blot analysis and eventually specific peptides immunoassay (Peptilav: Diagnostics Pasteur). 2) The criterion for HIV infection is the presence of specific antibodies at 18 months of age. 3) Viral cultures were performed: HIV-1 detection was done by p24 antigen test on supernatants, HIV-2 detection by measure of reverse transcriptase activity.

RESULTS: 1) The French Pediatric Study includes now more than 1,300 children born to HIV-1 mothers and 47 born to HIV-2 mothers. 2) 528 babies born to HIV-1 mother older than 18 months of age have a known serologic status: 99 are seropositive (18.8%) and 429 have seroreverted. 3) On the other hand, 25 babies born to HIV-2 seropositive mothers, older than 18 months of age, have a known serologic status: all have seroreverted. Moreover, 67 cultures performed for 30 children born to HIV-2 mothers have been all negative (the sensitivity of HIV-1 culture in our lab is 95% for infected children after 1 month of age). So, none of the 25 children born to HIV-2 mother is infected.

CONCLUSIONS: In this study, the HIV-1 materno-foetal transmission rate is evaluated at 18.8 (+/- 3.3) %. The HIV-2 materno-foetal transmission rate is significantly lower (p less than 0.05).

Keywords: AEGIS, HIV-2, HIV-1, HIV Infections, HIV Seropositivity, Blotting, Western, Mothers, Prospective Studies, Whites, France, Infant, Newborn, Human, Infant, Child, transmission, ICA8KWDaegis,hiv-2,hiv-1,hivinfections,hivseropositivity,blotting,western,mothers,prospectivestudies,whites,france,infant,newborn,human,infant,child,transmission,ica8
920719
WeC1063

Copyright © 1992 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.