AEGiS-08IAC: Natural history of HIV-2 vs. HIV-1: clinical and immunological study in a cohort of female sex workers.

8th International AIDS Conference


Amsterdam, Netherlands — July 19-24, 1992

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Natural history of HIV-2 vs. HIV-1: clinical and immunological study in a cohort of female sex workers.

Int Conf AIDS 1992 Jul 19-24; 8:We57 (abstract no. WeC 1066)
Siby T, Thior I, Marlink R, Diaw PA, Traore I, Hellinger J, Ndoye I, Mboup S, Kanki P, Essex M; Universite Cheikh Anta Diop, Dakar, Senegal.

OBJECTIVES: To compare the clinical and immunological evolution HIV-2 vs. HIV-1 infection.

METHODS: Since 1987, asymptomatic female sex workers visiting the National STD Clinics in Senegal have been enrolled in a prospective study including clinical follow-up, T-cell subsetting in the latter 2 years of study, and tuberculin skin testing.

RESULTS: With 353 women enrolled in the study, complete follow-up rate is 80% and active follow-up has produced vital status information on another 10%. Clinical outcome is summarized utilizing person-years observed (PYO) and incidence rates (IR). Dual reactive individuals are currently excluded. TABULAR DATA, SEE ABSTRACT VOLUME. Rate ratios of HIV-1:HIV-2 were significantly greater than 1 for AIDS, CDC IV and death when incidence rates of disease outcomes were compared. Immunologic parameters, abnormal T-cell subsets and skin test anergy were intermediate for the HIV-2+ women when compared to seronegative and HIV-1+ women, although enrollment values are not available prior to 1989.

CONCLUSIONS: For the first time, significant differences can be shown in actual disease progression rates between HIV-1 and HIV-2. Seroincident cases need to be accumulated within this cohort to more precisely determine disease outcome rate differences.

Keywords: AEGIS, HIV-2, HIV-1, HIV Infections, Sexually Transmitted Diseases, Tuberculin Test, Prospective Studies, Ambulatory Care Facilities, Tuberculin, Acquired Immunodeficiency Syndrome, Incidence, Senegal, Human, Female, immunology, ICA8KWDaegis,hiv-2,hiv-1,hivinfections,sexuallytransmitteddiseases,tuberculintest,prospectivestudies,ambulatorycarefacilities,tuberculin,acquiredimmunodeficiencysyndrome,incidence,senegal,human,female,immunology,ica8
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WeC1066

Copyright © 1992 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.