Int Conf AIDS 1994 Aug 7-12; 10:51 (abstract no. PS14) Gissmann L, Fisher S;
The clinical manifestation by human papillomavirus (HPV) infection can vary considerably depending on the virus type as well as the location (i.e. skin or mucosa). Infection can either lead to the development of papillomas or intraepithelial lesions which, under certain circumstances, can progress into malignant tumors. On the other hand, infection may become latent without any clinical symptoms. Although little is known about the mechanisms which regulate latency versus overt infection epidemiologic studies clearly demonstrate that the immune system must be important in this scenario. In fact, patients with inherited or (naturally or iatrogenically) acquired immunosuppression do have a higher risk to develop HPV-associated diseases. It is expected that studying these patients will augment our understanding of the host control of persistent viral infections.
Keywords: AEGIS, Papillomavirus, Human, Papillomavirus Infections, Epidemiologic Studies, Human, ICA10 940807
PS14
