Host factors in the immunopathogenesis of human immunodeficiency virus (HIV) disease.
Int Conf AIDS 1994 Aug 7-12; 10:4 (abstract no. PS2) Fauci AS; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
A complex array of immunopathogenic mechanisms that are multiphasic and multifactorial are involved in the establishment and progression of HIV disease. Following primary infection, an acute viremia occurs with wide dissemination of HIV. During this early viremic phase, virus enters the lymphoid tissue, trapped within the processes of follicular dendritic cells. In addition, during this phase of primary infection certain patients show major expansions of certain V beta subsets of CD8+ T cells which are manifestations of responses to HIV and which may be associated with both protective and harmful effects. Thus, events that occur soon after initial infection with HIV are critical to the subsequent course of HIV disease and may be extremely important in the control of the progression of HIV infection. In addition, inappropriate immune activation and elevated secretion of certain immunoregulatory cytokines occur during HIV infection. These cytokines play a role in the regulation of HIV expression in the tissues and, ultimately, influence the course of disease. In studies of HIV-infected individuals who are long term non-progressors despite up to 11 years of infection, it was found that these patients have preserved lymph node architecture, low viral burden and viral expression compared to individuals who are infected for comparable periods of time, but who progress in their HIV disease. The implications of host factors in the immunopathogenesis of HIV disease will be discussed.
Keywords: AEGIS, HIV, HIV Infections, Carrier Proteins, Lymphoid Tissue, host factors, Viremia, HIV Antibodies, Lymph Nodes, Cytokines, Antiviral Agents, T-Lymphocytes, Dendritic Cells, Follicular, Human, ICA10 940807
PS2
