AEGiS-11IAC: Impact of pregnancy on maternal AIDS (a prospective study).

11th International AIDS Conference

Vancouver, British Columbia — July 7-12, 1996

Impact of pregnancy on maternal AIDS (a prospective study).

Int Conf AIDS 1996 Jul 7-12; 11:33 (abstract no. LB.C.6054)
Kumar RM, Khuranna A, Uduman S; Faculty of Medicine and Health Sciences, United Arab Emirates University, Alain, UAE. Fax: (9713) 657134.

AIM: To assess the impact of pregnancy on maternal AIDS among tribal women from India. Design: At Government hospital in Manipur, 71 women with AIDS (CDC III/IV) were identified and prospectively studied from December 1992 to January 1996. Of these 71, 32 were pregnant (Group A) and 39 non-pregnant (Group B). Both groups were matched for age, parity, demographic characteristics, CD4 lymphocyte counts and AIDS defining disease.

RESULTS: In both groups, surprisingly, Pneumocystis Carinii Pneumonia (PCP) was the primary AIDS defining illness followed by miliary tuberculosis. In Group A, 18/32 (56%) women died within 17 months of getting pregnant as a direct cause of rapidly progressing AIDS defining illness compared to 10/39 (26%) in Group B (p=0.017, odds ratio 3.7285 CI=1.23, 11.58). Of the 18 deaths, 13 died in the antenatal period, 3 after medical termination of pregnancy and 2 in the immediate post partum period. The remaining 14 (44%) delivered vaginally. Mean survival time for the 10 pregnant women who died was 9.72 months compared to 22.6 months for the 10 deaths among the non-pregnant women (p is less than .0066). All births were preterm, the babies were infected with the AIDS virus (vertical transmission rate 100%) at birth. 9 of these infants died within 6 weeks of prematurity and clinical diagnosis of AIDS defining illness.

CONCLUSION: Pregnancy has a detrimental effect on AIDS with a significant increase in maternal and infant Morbidity and mortality.

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LBC6054