AEGiS-11IAC: Sydney blood bank cohort: (SBBC) additional long-term non-progressor with HIV (LTNP) identified; immunological update on SBBC 12-15 years post infection.

11th International AIDS Conference

Vancouver, British Columbia — July 7-12, 1996

Sydney blood bank cohort: (SBBC) additional long-term non-progressor with HIV (LTNP) identified; immunological update on SBBC 12-15 years post infection.

Int Conf AIDS 1996 Jul 7-12; 11:33 (abstract no. LB.C.6056)
Learmont J, Rhodes D, Soloman A, Wood J, McIntyre L, Dyer W, Geczy A, Deacon N, Sullivan J; NSW Blood Transfusion Service, Sydney, NSW, Australia. Fax: 612/229-4479.

OBJECTIVES: To identify the recipient of a unit donated in 1981 by the single donor in the SBBC. To monitor the immunological and surrogate markers for HIV progression of the SBBC. These include CD4, CD8, CD4:CD8 ratio, CD3 and total lymphocyte counts and p24 available data.

METHODS: The destination of a unit donated in February 1981 was known but the hospital blood bank was unable to identify the recipient of the unit through their records. Sydney Blood Bank lookback staff traced the unit after examining 5000 patient notes from a possible 20,000 patients who could have received the unit. Results of the recipients and the donor in the SBBC have been compiled and collated since their diagnosis. Test results have been analyzed to enable the determining of any possible trends.

RESULTS: The 50 year old recipient of the unit of red cells was transfused after a motor vehicle accident in February 1981. He has tested anti-HIV positive and is now the longest non-progressor recipient identified in the cohort. He is asymptomatic with CD4 and CD4% in the normal range and HIV-1 is defective in the nef/LTR region, similar to the SBBC strain of HIV-1 previously reported. The SBBC continue to maintain CD4, CD8, CD4:CD8 ratio, CD3 trends within the ranges for HIV negative individuals, some 12-15 years post infection. They have never received anti-viral therapy. Plasma Viral load for the SBBC range from below detection to 2 x 10(3) HIV RNA copies/ml and p24 antigen results continue to be negative for the cohort. One member is Hepatitis C positive (apparently transfusion transmitted) and all are negative for Hepatitis B, HTLV-1, HTLV-2. The oldest member (81 years) of the cohort died in November 1995 from causes unrelated to HIV/AIDS.

CONCLUSIONS: Lookback has successfully traced and enlisted an additional Long-Term Non-Progressor recipient as a member of the SBBC. This recipient is the longest LTNP in the cohort and has a similar attenuated virus as has been previously reported in the SBBC. The SBBC remain asymptomatic and maintain a very low viral load 12-15 years post HIV-1 infection.

960707
LBC6056