Beta-chemokines inhibit HIV-1 entry into CD4+ cells via the C-C CKR-5 co-receptor.
Int Conf AIDS 1996 Jul 7-12; 11:37 (abstract no. Mo.A.275) Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayana C, Maddon PJ, Koup RA, Moore JP, Paxton WA; The Aaron Diamond AIDS Research Center, New York, NY. Fax: (212) 725-1126.
The beta-chemokines MIP-1alpha, MIP-1beta and rantes inhibit infection of CD4+ T-cells by primary, NSI HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T-cells from some HIV-1 exposed-uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor C-C CKR-5 in CD4+, non-permissive human and non-human cells renders them infectable by NSI strains, and also allows env-mediated membrane fusion. C-C CKR-5 is a second receptor for NSI primary viruses.
Keywords: AEGIS, Antigens, CD4, HIV-1, Chemokines, CC, RANTES, Macrophage Inflammatory Protein-1, Membrane Fusion, Cell Fusion, T-Lymphocytes, Human, ICA11
