AEGiS-11IAC: IgA anti-HIV-1 antibody in cerebrospinal fluid and serum samples from adult HIV-infected patients.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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IgA anti-HIV-1 antibody in cerebrospinal fluid and serum samples from adult HIV-infected patients.

Int Conf AIDS 1996 Jul 7-12; 11:438 (abstract no. Pub.A.1006)
Ueda M, Yamashiro R, Oliveira CA, Sanches RF, Paz RB, Palhares MC; STD/AIDS Reference & Training Centre-Secretary of Health of Sao Paulo State, Sao Paulo, Brazil. Fax: 55-11-853.3505.

OBJECTIVE: To evaluate the occurrence of specific IgA antibody (Ab) to HIV-1 in paired CSF and serum samples from HIV-infected patients (px) with CNS alterations or neurologic complaints.

METHODS: From 371 adult male and female HIV-positive px clinically assessed by CDC AIDS case-definition criteria, 437 paired CSF/serum samples were analysed by means of capture immunoadsorption test (CIAT) for HIV-1 specific IgA Ab detection. Blood-brain barrier (BBB) status was evaluated in 69 paired CSF/serum samples according to REIBER & FELGENHAUER graph method (1987). Serum samples from HIV-negative individuals but seropositive for syphilis, Chagas ' disease, infectious mononucleosis, and from healthy persons constituted control group for CIAT specificity analysis.

RESULTS: It is worthy of note the findings of high proportion of anti-HIV-1 IgA Ab in CSF samples from adult HIV-1-infected px with CNS alterations or neurologic complaints with or without BBB disturbance. This disturbance could be caused by HIV or even by opportunistic agents.

CONCLUSIONS: Detection of HIV-1 specific IgA Ab in CSF and serum samples may be a valuable tool to be used as diagnostic marker sincelgA immunoglobulin is normally absent in CNS compartment. A local production of HIV IgA Ab has been suggested in some cases with intact BBB or without disturbance in the barrier (zone 1 or zone 4 profiles, respectivelly). Consistent presence of IgA Ab to HIV-1 in the most of serum samples indicates that the biosynthesis of this Ab isotype may be relevant for biologic and clinical deterioration.

Keywords: AEGIS, HIV-1, HIV, Immunoglobulin A, HIV Antibodies, HIV Infections, Antibodies, Anti-Idiotypic, Acquired Immunodeficiency Syndrome, AIDS Dementia Complex, HIV Core Protein p24, HIV Envelope Protein gp120, Blood-Brain Barrier, Antibodies, Central Nervous System, Anti-HIV Agents, Immunoglobulins, Adult, Female, Male, Human, cerebrospinal fluid, ICA11

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PubA1006

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.