AEGiS-11IAC: Some patterns of AIDS pathogenesis in Ukraine.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Some patterns of AIDS pathogenesis in Ukraine.

Int Conf AIDS 1996 Jul 7-12; 11:440 (abstract no. Pub.A.1013)
Marichev IL, Antonenko SV, Scherbinskaya AM, Kruglov YV, Barbasheva YV, Protsap EI, Grin EV, Frolov AF; Institute of Epidemiology & Infective Diseases, Health Ministry of Ukraine, Kyiv, Ukraine. Fax: (044) 277-2411.

OBJECTIVE: In 1992-1994 the increase of AIDS patients was rather low (25-40 cases/year); this marker became 3 times higher in 1995 due mostly to intravenous drug abusers. Taking into consideration the unfavourable social and economical changes in Ukraine due to Chernobyl explosions well as immunopopulational changes and tendencies of AIDS irradiation among drug abusers the problems of interaction between AIDS agent biology and persistent infections activation are of great significance, the secondary immunodeficiency phenomena being widely registrated in different groups of our population.

RESULTS: The biological patterns of 33 HIV-1 isolates from ukrainian citizens have been studied. The heterogeneity of biological patterns has been proved such as pathogenity, tropism spectra, CPE. 83 % of our isolates belong to the type slow/low, 17 % are of the type rapid/high. The activation of CMV, HSV, and HBV in HIV-infected patients influenced the changes of HIV isolates biological patterns, the HIV infectivity having become higher and similar to rapid/high type. Taking into account that 56% of our AIDS patients died during the first year of infection.

CONCLUSIONS: We propose the AIDS infection in Ukraine to possess some peculiar characters due to "primary original" immunodisfunctions leading to latent persistent agents activation; so the immunodeficiency virus possessing low infective properties favorises the aggressive potencies of opportunic infections causing high patients lethality.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, HIV, HIV-1, HIV Seropositivity, HIV Infections, Cytomegalovirus, Simian Acquired Immunodeficiency Syndrome, HIV Seroprevalence, Infection, Cytomegalovirus Infections, Simplexvirus, Ukraine, Human, etiology, ICA11

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PubA1013

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.