AEGiS-11IAC: HIV-infection effect on immune system cells genome.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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HIV-infection effect on immune system cells genome.

Int Conf AIDS 1996 Jul 7-12; 11:440 (abstract no. Pub.A.1014)
Antonenko SV, Barbasheva YV, Shcherbinska AM; Research Institute of Epidemiology & Infectious Diseases, Kiev, Ukraine. Fax: 380(044)277-24-00.

OBJECTIVE: To study interdependence of genetic stability and functional activity of immunocompetent cells at different HIV infection stages.

METHODS: The levels of spontaneous DNA repair synthesis, quantity of single-stranded breaks in DNA peripheric lymphocytes, sensitivity to damage influences, ability to restorate UV-induced DNA damages have been studied. We have also investigated lymphocytes proliferative response to mitogen administration. 52 HIV-infected and 35 healthy persons have been investigated.

RESULTS: The degrees of structural and functional impairs in lymphocytes genome, both qualitive and quantitive, have been shown to be correlated with HIV-infection stage. AIDS patients have shown increased levels of spontaneous DNA repair synthesis (3 times higher), increased quantity of single-stranded DNA breaks (11 - 18%), decreased ability to restore DNA damages (2 - 2,5 times lower) comparing to healthy persons. We have also found the changes of lymphocyte immune function. Some ultrastructural damages suggest non-specific lymphocytes activation to take place in AIDS patients.

CONCLUSIONS: Further studies are in progress because of these data to be of significant value for understanding of HIV infection pathogenesis.

Keywords: AEGIS, HIV Infections, Acquired Immunodeficiency Syndrome, HIV, Lymphocytes, Anti-HIV Agents, HIV Antibodies, HIV Antigens, Genome, Lymphocyte Activation, DNA Repair, DNA Damage, DNA, Human, genetics, immunology, ICA11KWDaegis,hivinfections,acquiredimmunodeficiencysyndrome,hiv,lymphocytes,anti-hivagents,hivantibodies,hivantigens,genome,lymphocyteactivation,dnarepair,dnadamage,dna,human,genetics,immunology,ica11

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PubA1014

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.