AEGiS-11IAC: Molecular epidemiology of HIV-1 infection in the former USSR.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Molecular epidemiology of HIV-1 infection in the former USSR.

Int Conf AIDS 1996 Jul 7-12; 11:441 (abstract no. Pub.A.1019)
Bobkov AF, Cheingsong-Popov R, Selimova L, Kazennova E, Karasyova N, Ladnaya N, Pokrovsky V, Weber J; The D.I. Ivanovsky Institute of Virology, Moscow, Russia. Fax: 095-190-2873. E-mail: NICK@nasel.msk.ru.

OBJECTIVE: To characterize the HIV-1 genetic subtypes circulating in different risk groups in the former Soviet Union republics.

METHODS: PBMC DNA samples derived from HIV-1 infected individuals from different risk groups in the former USSR were analysed by heteroduplex mobility assay (HMA) and env gene sequencing.

RESULTS: The env genetic subtypes were analysed in 200 subjects, by HMA. Six subtypes were identified in heterosexuals, including A, B, C, D, G, and H. Homosexual men were infected predominantly with the B subtype. The most G subtype viruses were epidemiologically linked with the nosocomial epidemic of HIV-1-infection in South Russia. Several cases of subtype A and H transmission during blood transfusion were also observed. Sequence analysis revealed the HIV-1 strains highly divergent from the consensus sequences.

CONCLUSIONS: At least six subtypes of the HIV-1 were independently introduced in the former USSR. Sequence analysis demonstrated the high level of nucleotide divergence among HIV-1 strains in the former USSR.

Keywords: AEGIS, HIV Infections, USSR, HIV-1, Epidemiology, Molecular, Genes, env, Heterosexuality, HIV-1 Reverse Transcriptase, Disease Outbreaks, Russia, Human, Male, genetics, ICA11KWDaegis,hivinfections,ussr,hiv-1,epidemiology,molecular,genes,env,heterosexuality,hiv-1reversetranscriptase,diseaseoutbreaks,russia,human,male,genetics,ica11

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PubA1019

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