AEGiS-11IAC: Studies on medicine compounds of Kangfuxin

AEGiS-11IAC: Studies on medicine compounds of Kangfuxin - immunity compounds.

11th International AIDS Conference

Vancouver, British Columbia — July 7-12, 1996

Studies on medicine compounds of Kangfuxin - immunity compounds.

Int Conf AIDS 1996 Jul 7-12; 11:443 (abstract no. Pub.B.1032)
Qixun L, Yunlong X, Shide L; Kunming Institute of Botany, the Academy of Sciences of China, China. Fax: (0871)5150227.

OBJECTIVE: To improve the human body's immune functions and treatment AIDS.Over the years, our research group has been devoted to efforts mostly of physiochemical and biochemistry theory and application. Up to now, we have developed hopeful traditional medicines and the efficient constituents from the minority areas in southwest China. Ten components we obtained have been identified to have anti-AIDS activity by National Cancer Institute of America(NCI). Besides, we also obtained "Kun one" which has powerful immunotherapeutic activity. "Kun one" is a group of compound isolated from Kangfuxin. In vivo immunopharmacological properties of the traditional Chinese medicine Kangfuxin has elucidated its mechanism. Method: Kangfuxin was extracted with aqueous EOH. The contracted extraction was dissolved in water. The aqueous liquid was chromatograpied by active charcoal column. The part absorbed by active charcoal was pharmacologically tested in Dali Medical College in Yunnan with immune cells, thymus and spleen of mouse.

RESULTS: The results showed that weight of thymus of mouse had increased. DNCB skin allergy and phagocyte phagocytosis had exceeded immune strengthen reagoent-(-)-imidazole. This part could regulate immunotherapeutic functions of an organism.

CONCLUSIONS: 1. "Kun one" have stimulatory effect for phagocytosis of macrophages2. Chemoluminescence was also enhanced after oral administration of "Kun one" to normal mice and after i.p injection to immuno-depressed tumor-bearing mice.3. The authors therefore suggest that the therapeutic effect of "Kun one" may be due, at least in part, to its stimulatory effect on nonspecific cellular defense mechanisms.

Keywords: AEGIS, Pharmaceutical Preparations, Medicine, Chinese Traditional, Thymus Gland, Phagocytosis, Drugs, Chinese Herbal, Spleen, Dinitrochlorobenzene, Adjuvants, Immunologic, Anti-HIV Agents, Analgesics, Charcoal, China, Americas, Human, Animal, Mice, immunology, ICA11

960707
PubB1032