AEGiS-11IAC: Disseminated histoplasmosis (DH) in AIDS patients in Guatemala.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Disseminated histoplasmosis (DH) in AIDS patients in Guatemala.

Int Conf AIDS 1996 Jul 7-12; 11:446 (abstract no. Pub.B.1054)
Segura L, Rojas M, Klaskala W, Baum MK; Fogarty International Training Program, University of Miami, USA. Fax: (305) 243-4687. E-mail: mmiguez@mednet.med.miami.edu.

OBJECTIVE: To describe epidemiological and clinical characteristics of AIDS patients diagnosed with Disseminated Histoplasmosis (DH) in San Juan de Dios Hospital in Guatemala.

METHODS: Medical records of AIDS patients hospitalized from 1985 to 1994 were retrieved and evaluated to obtain clinical information about the history of Disseminated Histoplasmosis.

RESULTS: Of 120 AIDS patients, eight (6.7%) were diagnosed with Acute Disseminated Histoplasmosis. All cases were homosexual males between 15 and 40 years of age. The clinical signs and symptoms included: diarrhea(100%), fatigue(100%), weight loss (100%), fever of unknown origin (75%), cough(75%), spleen enlargement(100%), hypotension(100%), anemia, low platelets and hematuria(100%). Six patients developed AIDS associated opportunistic infections (Pulmonary and Miliary Tuberculosis). Disseminated Histoplasmosis was diagnosed utilizing blood smear, bone marrow-culture(75%) and hepatic biopsy (25%). Four patients were treated with Itraconazole, the other four did not receive any medication. All patients died within 10 days from the day of diagnosis. In 4 patients DH was the final cause of death.

CONCLUSIONS: Prognosis of long survival of the patients diagnosed with Disseminated Histoplasmosis in Guatemala is poor. Prior to the first AIDS diagnosis in Guatemala (1984) there was no registered case of Disseminated Histoplasmosis in the hospital records.

Keywords: AEGIS, Histoplasmosis, Acquired Immunodeficiency Syndrome, Itraconazole, Opportunistic Infections, Antibiotics, Antifungal, Biopsy, Tuberculosis, Miliary, Bone Marrow, Guatemala, Human, Male, ICA11KWDaegis,histoplasmosis,acquiredimmunodeficiencysyndrome,itraconazole,opportunisticinfections,antibiotics,antifungal,biopsy,tuberculosis,miliary,bonemarrow,guatemala,human,male,ica11

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PubB1054

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.