AEGiS-11IAC: Pulmonary opportunistic pathogens in AIDS. A hundred autopsies study in Brazil.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Pulmonary opportunistic pathogens in AIDS. A hundred autopsies study in Brazil.

Int Conf AIDS 1996 Jul 7-12; 11:447 (abstract no. Pub.B.1055)
Rodrigues AC, Basilio CA, Moraes AL, Valle HA, Monteiro GB, Borba SM, Santos MA, Ramos IH; Gaffree e Guinle University Hospital, University of Rio de Janeiro, Rio de Janeiro, Brazil. Fax: +55-21-2640025.

OBJECTIVE: To describe lung infections due to opportunistic pathogens in patients with AIDS and possible concurrent infections.

METHODS: A retrospective study of 100 AIDS patients autopsies, performed from 1984 to 1994, was made by sistematic histopathological examination and imunohistochemical methods.

RESULTS: The group's main characteristics were: males (82%), whites (72%) and an average age of 35 years (range 15-62). The risk factors for AIDS were: homosexuality (55%), injecting-drug use (19%), bisexuality (15%), blood transfusions (10%), 3 women were infected by heterosexual transmission. The lung was infected by opportunistic pathogens in 98% of cases, with the following distribution: Cytomegalovirus (CMV) (44%), pyogenic bacteria (35%), Mycobacterium tuberculosis (28%), Pneumocystis carinii (14%), Mycobacterium avium (9%), Candida albicans (9%), Cryptococcus neoformans (5%), Toxoplasma gondii (3%), Schistosoma mansoni (3%), Herpes simplex (1%), Legionella pneumophila (1%), Histoplasma capsulatum (1%), Aspergillus sp. (1%), other viruses (2%). Coinfections were frequently found (49%). CMV and micobacteria (15%) and CMV and pyogenic bacteria (7%) were the most commonly seen. CMV was the most frequent opportunistic pathogen in concurrent infections and pyogenic bacteria were the most frequent opportunistic pathogens in single infections.

CONCLUSIONS: The lung is usual target for opportunistic infections in patients with AIDS. CMV is the most frequent opportunistic pathogen in coinfections, which are common.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Cryptococcosis, Opportunistic Infections, Respiratory Tract Infections, Autopsy, Pneumocystis carinii, Cytomegalovirus Infections, Lung, Herpes Simplex, Cytomegalovirus, Cryptococcus neoformans, Risk Factors, Retrospective Studies, Lung Diseases, Brazil, Human, Male, Female, ICA11

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PubB1055

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.